Protein Alignment Ekar and grid2

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_031759030.1
• Gene: grid2 / 100487676
• XenbaseID: XB-GENE-955038
• Length: 1007
• Species: Xenopus tropicalis
• Alignment Length: 881
• Identity: 237/881 - (26%)
• Similarity: 436/881 - (49%)
• Gaps: 104/881 - (11%)

  Fly     9 LFQFLSYG-LGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFD 72
            :|..:|:| .....::.||||| ::....:.|: ||.|:..||:::.:|....:.:.|.:|:..:
 Frog    12 VFWTVSWGRTRADSIIHIGAIF-DESAKKDDEV-FRMAVADLNLNEDILQTEKITFSVTFVDGNN 74

  Fly    73 SFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPN--IGRSA---------------- 119
            .|:.||:.|.|:..|:.|:.|......|..:.|:.||:.||:  |.||.
 Frog    75 PFQAVQEACDLMSQGILALVSSIGCASAGSLQSLADAMHIPHLFIQRSTARTPRSGCGLQRSSGI 139

  Fly   120 HDFSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQ-LSR-SFHG-EVHMRQVSRD 181
            .|::::|.|...|.:.....|.:|. |.:|.:.::....|..:.: |.| |..| :|.:::|..:
 Frog   140 DDYTLSVRPPVYLNDVILRVVTEYA-WQKFIVFYDNNYDIRGIQEFLDRVSQQGMDVALQKVENN 203

  Fly   182 -----------SYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLET 235
                       ..:..||.:: ..:...|:..:.......:..:::..:..:..|::..:.::..
 Frog   204 INRMITGLFATMRIEELNRYR-DTLRRAILVMSPTTAKAFITEVVETNLVAFDCHWIIINEEIND 267

  Fly   236 YDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTI---------- 290
            .|:::            || ...:|...|::......|:..::.:...|...:::
 Frog   268 LDVQE------------LV-RRSIGRLTIIRQTFPVPHNSSQRCFRGNHRISTSLCDPKDPFSQN 319

  Fly   291 LESEPALMFDSVYVFAIGL-QTLEQSHSLTLLNISCEEENS--WDGGLSLINYLNAVEWKGLTGP 352
            :|.....::|:|.:.|... :.||.....::.:::|..:||  |.||.|::..:......||||.
 Frog   320 MEITNMYIYDTVLLLANAFHKKLEDRKWHSMASLTCIRKNSKPWQGGRSMLETVKKGGVSGLTGA 384

  Fly   353 IQF-KDGQRVQFKLDLIKLKQ-----HSIVKVGEWTPHGHLNITEPSMFFDAGSMNVTLVVITIL 411
            :.| :||.......:::....     ..|.|:|.|.|...||.:......:.....|.|.|.|:|
 Frog   385 LDFSEDGGNPNIYFEILGTNYGEELGRGIRKLGFWNPVTGLNGSLTDRKLENNMRGVVLRVATVL 449

  Fly   412 ETPYVMMHYGKNFTGN-ERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQ 475
            |.|:||:  .:|..|. :::.||.:|:|:.:|..:||.|.:.:..|.|||:...: |.|||::.:
 Frog   450 EEPFVMV--SENVLGKPKKYQGFSIDVLDALSSYLGFKYEIYVASDHKYGSPQAD-GSWNGLIGE 511

  Fly   476 LMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLI 540
            |:..:||:.:.::|||..||:|:|||..:|:..:.:|.: ...:...:|:.:.|..:.:|..:..
 Frog   512 LLLKRADMGISALTITPDRENVVDFTTRYMDYSVGVLLR-KAEKTVDMFACLAPFDLSLWACIAG 575

  Fly   541 AYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLT--DSFWFTIGTFMQQSPDIYPRAMS 603
            ...||.|.:|::..|:|           ..:.:|:..|.|  :|.||..|:|:||..::....::
 Frog   576 TVLLVGLLVYLLNWLNP-----------PRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLA 629

  Fly   604 TRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTL-DSG-------- 659
            ||::...|..|:||:::|||||||||||..|:.:.|::.:||:.||:|.|||: ||.
 Frog   630 TRMMMGAWWLFALIVISSYTANLAAFLTISRIESSIQSLQDLSRQTDIPYGTVFDSAVYEHVRVK 694

  Fly   660 STMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYE--DGIKRVNQGNYAFLMESTMLDYIV--QRD 720
            ....|.|||:   |.::|| |.|:...:.....|  :||::|..|||||:.::.:|:||.  .:|
 Frog   695 GMNPFERDSM---YSQMWR-MINRSNGSENNVQESLEGIQKVKHGNYAFVWDAAVLEYIAINDQD 755

  Fly   721 CNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQ 785
            |:...:|..:..:|||||...|||:||..|..|||||:.||:.:|..|||....:.....:...:
 Frog   756 CSFYTVGNTIADRGYGIALQHGSPYRDIFSQRILELQQNGDMDILKHKWWPRNGQCELHSSMDTK 820

  Fly   786 SKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYN 821
            .|.:||.::|..|||.:|.|||:::..:|..|.|:|
 Frog   821 QKGSSLDIKSFSGVFCILAAGIVLSCFIAMVETWWN 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	84/416 (20%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	134/384 (35%)
		Lig_chan	532..806	CDD:459656	100/288 (35%)
grid2	XP_031759030.1	Periplasmic_Binding_Protein_type1	28..429	CDD:471960	84/417 (20%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	134/384 (35%)