Protein Alignment Ekar and grik3

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_017206939.1
• Gene: grik3 / 100334689
• ZFINID: ZDB-GENE-211021-1
• Length: 991
• Species: Danio rerio
• Alignment Length: 926
• Identity: 349/926 - (37%)
• Similarity: 557/926 - (60%)
• Gaps: 79/926 - (8%)

  Fly     8 LLFQFLSYGLGVPPLVRIGAIFSNQPG----MYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYV 68
            :|| ::....|:|.::|||.||....|    :.:.||||::|::.:|.:::|||.||:.|.::.:
Zfish    17 VLF-WIQSSFGMPHVIRIGGIFEQTDGPVALVSSEELAFKFAVNNINRNRTLLPNTTLTYDIQRI 80

  Fly    69 NRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIG-RSAH-------DFSIN 125
            |.:||||..:|.|..:.:||.|:|.|:.|..:..:.|||:||::|:|. |..|       .|..|
Zfish    81 NIYDSFEASRKACDQLSLGVVAIFGPSHSSSSNAVQSICNALEVPHIQVRWKHHPMDNRDTFYAN 145

  Fly   126 VYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQL----SRSFHGEVHMRQVSRDSYVS- 185
            :||....::||..|::|:|.|....::::...|:|.|.:|    || ::..:.:||:..|:..:
Zfish   146 LYPDYSSLSYAILDLVQFLKWKTATVVYDDSTGLIRLQELIMAPSR-YNIRLKIRQLPMDTVDTR 209

  Fly   186 -ALNEFKGKEIHNIIIDTNSNGISILLKNI-LQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNI 248
             .|.|.|......||.|.:....:.:||.. :...|.|| |||:||:.||...:||.:::..||:
Zfish   210 PLLKEMKRSREFRIIFDCSHTMAAQILKQAQMMGMMTEY-YHYIFTTLDLMAINLEPYRFCGVNM 273

  Fly   249 TSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLE 313
            |.||:::..:..|..|::...| ...|..||...|   ...|:.::.||.:|:|::.::..|...
Zfish   274 TGFRILNVDNPQVASIVEKWSL-ERQIPPKPDSGL---LEGIMTTDAALTYDAVHIVSVSYQHAP 334

  Fly   314 QSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFK--DGQRVQFKLDLIKLKQHSIV 376
            |   :|:.::.|.....|..|...::::....|.||||.:.|.  .|.|..|.||::.||:..:.
Zfish   335 Q---MTVNSLQCHRHKPWRFGGRFMSFIKESHWDGLTGRLCFNRTTGLRTDFDLDIVSLKEDGLQ 396

  Fly   377 KVGEWTPHGHLNITE-PSMFFDAGSMNVT-------LVVITILETPYVMMHYG-KNFTGNERFYG 432
            |||:|:..|.||||| |..    ..||:|       ||:.||||.||||:... |...||:||.|
Zfish   397 KVGKWSASGGLNITEVPRQ----NGMNITDSLSNRSLVITTILEEPYVMLKKSDKALVGNDRFEG 457

  Fly   433 FCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESV 497
            ||:|:|:.::..:||.|.:.||||.|||.:| :.|:||||:.:||:::|||||..:|||:.||..
Zfish   458 FCIDLLKELASILGFSYEIHLVPDGKYGFQD-DKGQWNGMIRELMEHRADLAVAPLTITFMREKA 521

  Fly   498 IDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKC 562
            |||:|||:|.|||||::.|.|..:..|||:||:..:||:|:|:||..||..::::.:.||.||..
Zfish   522 IDFSKPFLNTGISILYRKPNSTNSGFFSFLNPMTPDIWVYILLAYLGVSCVLFVIARFSPYEWYD 586

  Fly   563 INACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLA 627
            .:.|:..:..:.|.|:|.:||||.:|:.|||..::.|:|:|||||...|.||:|||::|||||||
Zfish   587 AHPCNPGSDVVENNFTLLNSFWFGVGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLA 651

  Fly   628 AFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTY 692
            ||||.|||.:|:::|:|||.||:|.||.:..|:||:||:.|.:.|::|:|..|.:::.::|..:.
Zfish   652 AFLTVERMDSPVDSADDLAKQTKIEYGVVKDGATMSFFKKSRVSTFEKMWAFMSSRQSTSFVKSI 716

  Fly   693 EDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQ 757
            ||||:||.:.:||.|||||.::|:.:|:|||||:||::|:|||||.||||||:||||::|||.:.
Zfish   717 EDGIQRVLKSDYALLMESTTIEYVTRRNCNLTQVGGIIDSKGYGIGTPKGSPYRDKITIAILGIL 781

  Fly   758 ERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNF 822
            |.|.:.||.:|||..:  :|..   .::.:...:|::::||:|:||.:|::::..||..||.|..
Zfish   782 EDGRLHMLKEKWWSGS--SCLE---DERYETGPMGIQNLGGIFIVLASGLVLSVFVAIGEFIYKL 841

  Fly   823 RYNYEATP---------SQSVVNNKYNQDGILESERNYTPPDRSFWIEIAEELRYASWCMNKQKR 878
            |...|...         .|:||:       :.|:.....||..:...|.....::|     ..:|
Zfish   842 RKTAEREQVFLQCGDGRDQTVVH-------VRETGEAQAPPAAASHAEDGRSDQHA-----LLQR 894

  Fly   879 PALTRTCSKCTIPKGQ 894
            |:..|        |||
Zfish   895 PSPAR--------KGQ 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	122/386 (32%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	188/376 (50%)
		Lig_chan	532..806	CDD:459656	127/273 (47%)
grik3	XP_017206939.1	PBP1_iGluR_Kainate	32..410	CDD:380605	122/386 (32%)
		Periplasmic_Binding_Protein_Type_2	426..794	CDD:473866	185/368 (50%)