Protein Alignment Ekar and grin3bb

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_017213803.2
• Gene: grin3bb / 100333101
• ZFINID: ZDB-GENE-131122-77
• Length: 1114
• Species: Danio rerio
• Alignment Length: 998
• Identity: 218/998 - (21%)
• Similarity: 373/998 - (37%)
• Gaps: 254/998 - (25%)

  Fly    23 VRIGAIFSNQPGMYNSELAFRYAIHR-----LNMDKSLLP-ETTVDYYVEYVNRFDSFETVQKVC 81
            ||:||:...:     ..:..|.|:||     .....:.|| ..::|.........|.....:.||
Zfish    47 VRLGALLPPR-----QSVRVRAALHRALSGLAESGNNFLPYNLSLDVVAREAQSGDPESLFRCVC 106

  Fly    82 KLIRV-GVQAVFS-PTDSVLATHINSICDALDIPNIG--------RSAHDFSINV---YPSKQLV 133
            :.|.| ||.||.: |........:..:...|:||.|.        ::.:.|.:.:   .|...||
Zfish   107 QDIVVQGVSAVLAFPQTQEEIVQMEFMSSFLEIPFISIIEHGEPLKTQNRFHLQMTTRIPPSGLV 171

  Fly   134 NYAFNDVIQYLNWTR-FGIL-HEKEN-GIINLHQLSRSF---HGEVHMRQVSRDSYVSA----LN 188
            .... .|:|...|.. ..:| |..|: |:::|.:|...|   ..:.|:|.....|:.:|    ::
Zfish   172 ELLL-AVLQRSGWEESMAVLCHGWEDAGLLDLLKLQGRFGWGPSQWHLRAALNLSHSTARMANIS 235

  Fly   189 EFKGKEI---HN-----IIIDTNSNGISILLKN-------------ILQQQMNEYKYHYLFTSFD 232
            :|..:..   |:     ::...:....|.:|::             |:...::....|.:.....
Zfish   236 DFLSEHFNLDHSPPASVLLFGADPECASSVLRSAHDLGLTLPTVHWIMGHPLSPDALHSIGLPLG 300

  Fly   233 LETYDLEDFK-YNFVNITSFRLVDTADVGVKQILKDIGLYSHHI--FKKPYLNLHIKKSTILESE 294
            |..|...|.| .:|....:.:|::.|......:..|:.|..:.:  |.||
Zfish   301 LLAYGEVDHKPLDFYISDALQLINRAVTAATVVRPDLALIQNMVNCFDKP--------------- 350

  Fly   295 PALMFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGP-IQFKDG 358
                               ..|.|.            ..|..:..:|:...:.||||| |..::.
Zfish   351 -------------------NKHELP------------SSGQYIARFLSNTSFVGLTGPVIVQRNL 384

  Fly   359 QRV--QFKLDLIKLKQHSI-----VKVGEWTPHGHLNITEPSMFFDAGSMNVT------------ 404
            .||  ..|:.:..|::.::     |.||.| ..|.||:.|..::..:.....|
Zfish   385 SRVHTSHKVHIWSLRRDAVGQPTWVTVGSW-EGGRLNVEEQGLWQGSSPRQRTEGQMGREGRRWR 448

  Fly   405 ---------LVVITILETPYVMMH----------------------------YGKNFTGNERF-- 430
                     |.|:|::|.|:|...                            |.:...||:.|
Zfish   449 AGFPVSGSRLRVVTLVEHPFVFTREVDEDGNCPAGQYCLDAGTNSSETLDHLYAERAQGNKSFLP 513

  Fly   431 -------YGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSM 488
                   ||:|:|:||.:|.::.|::.|.:|.|.||||  .:.|:|.|:|..|:...||:||.|.
Zfish   514 PDYSKCCYGYCIDLLEKLSEDMNFEFDLYIVGDGKYGA--VKGGQWTGLVGDLLSGVADMAVTSF 576

  Fly   489 TITYARESVIDFTKPFMNLGISILFK-VPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIV 552
            :|..||..|||||.||.:..:.||.: ..|:.|  :.:||.||...:|:.:.:|..:.:|.
Zfish   577 SINSARSKVIDFTSPFFSTSLGILVRSKDTAAP--IGAFMWPLHWSMWMGIFVALHITALF---- 635

  Fly   553 GKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQS--------------PDIYPRAMS 603
              |:..|||             :.|.:|......:..|...|              ....|:..:
Zfish   636 --LTLYEWK-------------SPFGMTPHGRNRVKVFSYSSALNLCYAILFGRTVSSKTPKCWT 685

  Fly   604 TRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDL----ASQTEISYGTLDSGSTMTF 664
            .|.:.:.|..|.|::::||||||||.:..|:....:....|.    .|| ...:||:...|...:
Zfish   686 GRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDAKLHHPSQ-GFRFGTVRESSAEDY 749

  Fly   665 FRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDY--IVQRDCNLTQIG 727
            .:.|..|.::.:.:..:...|....|...|..:.     .||:|:..:|||  .:..||.|..:|
Zfish   750 MKKSFPEMHEYMRKFNEPTTPDGVATLKTDPPQL-----DAFIMDKALLDYEVSIDADCKLLTVG 809

  Fly   728 GLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLG 792
            .....:||||..|:.||....||..:...:..|.:.||:|||:|..  .| .|.....::...:|
Zfish   810 KPFAIEGYGIGLPQNSPLTSNISEFVSRYKSDGYMDMLHDKWYKVV--PC-GKRVFAVTETLQMG 871

  Fly   793 LESIGGVFVVLIAGIIVAAVV-----AF-------------FEFWYN--------FRYNYEATPS 831
            :....|:||:|..|:..|.:.     ||             |::|.:        ....||....
Zfish   872 IRHFSGLFVLLCVGVTGALLTLAGEHAFYRLVLPHIRRKQKFKYWLHTSQKIHRALNMTYEDVKR 936

  Fly   832 QSVVNNKYNQDGILESERNYTPP 854
            |.....|...   ::..:.:.||
Zfish   937 QRANTEKSCN---IQKAQPHPPP 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	81/426 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	115/447 (26%)
		Lig_chan	532..806	CDD:459656	69/293 (24%)
grin3bb	XP_017213803.2	Periplasmic_Binding_Protein_type1	39..427	CDD:471960	83/432 (19%)
		PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	113/423 (27%)
		Lig_chan	618..885	CDD:459656	69/294 (23%)