Protein Alignment Ekar and grin1b

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001137603.1
• Gene: grin1b / 100005675
• ZFINID: ZDB-GENE-051202-2
• Length: 937
• Species: Danio rerio
• Alignment Length: 921
• Identity: 226/921 - (24%)
• Similarity: 381/921 - (41%)
• Gaps: 172/921 - (18%)

  Fly     2 LIASGFLLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLN----MDKSLLPETTVD 62
            |:...||:....:.|...|..|.|||:.|.:    ..|..|:.|:.:.|    .||..:...:|
Zfish     3 LVLFAFLISCSCARGGCEPKTVNIGAVLSQK----RYEQVFKDAVTQANNIYGKDKFKMNAISV- 62

  Fly    63 YYVEYVNRFDSFETVQKVCK-LIRVGVQAVF-----SPTDSVLATHINSICDALDIPNIG----- 116
                 .::.::.:....||: ||...|.|:.     ...|.:..|.::.......||.:|
Zfish    63 -----THKPNAIQMALSVCEDLISNQVYAILVSHPPQSNDHLTPTPVSYTAGFYRIPVVGLTTRM 122

  Fly   117 -----RSAHDFSINVYPSKQLVNYAFNDVIQYLNWTRFGIL----HE------------------ 154
                 :|.|...:...|........:.|:::...|....::    ||
Zfish   123 SIYSDKSIHLSFLRTVPPYSHQAQVWFDMMREFQWNHIILIVSDDHEGRAAQKRLETLLEERETK 187

  Fly   155 -KENGIINLHQLSRSFHGEVHMRQV---SRDSYVSA-LNEFKGKEIHNIIIDTNSNGISILLKNI 214
             |.....||.|||..........:|   |:|:.::| |.|.|..|...||:..:.:..:.:.|..
Zfish   188 SKNRNYENLDQLSFDNKRGPKAEKVLLFSQDTNLTALLQEAKELEARVIILSASEDEAAAIYKVA 252

  Fly   215 LQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKP 279
            .|..|....|.:|....::                |.:.:..|..|:
Zfish   253 RQLNMTGSGYVWLVGEREM----------------SGKALSEAPDGL------------------ 283

  Fly   280 YLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLLNISC-EEENSWDGGLSLINYLNA 343
             |.|.:...   ::|.|.::|:|.|.|..:|.|.:..::|.....| ...|.|..|......|.:
Zfish   284 -LGLQLING---KNESAHIYDAVAVVAQSIQELFEKENITEPPRGCVGNTNIWKTGPLFKRVLMS 344

  Fly   344 VEW-KGLTGPIQFK-DGQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNITEPSMFFDAG------- 399
            .:: .||||.::|. ||.|......::..::..:|:||.:.....:...:..:.:..|
Zfish   345 SKYPDGLTGRVEFNDDGDRRFAHYSILNYQKTRLVQVGVYNGSQVVMNAQRKIIWPGGETEKPKG 409

  Fly   400 -SMNVTLVVITILETPYV------------------------MMHYGKNFTGNER------FYGF 433
             .|:..|.::||.:.|:|                        ::..|.|.|...|      .|||
Zfish   410 YQMSTRLKIVTIHQEPFVYVKPTLRDGTCKEEHTVNGVKIKKVICTGPNETIPGRPIVPQCCYGF 474

  Fly   434 CVDILETISREVGFDYILDLVPDRKYGAKD----PETGEWNGMVAQLMKYKADLAVGSMTITYAR 494
            |:|:|..::..:.|.|.:.||.|.|:|.::    ....|||||:.:|:...||:.|..:||...|
Zfish   475 CIDLLIKLAFTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGLADMIVAPLTINNER 539

  Fly   495 ESVIDFTKPFMNLGISILFK--VPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSP 557
            ...|:|:|||...|::||.|  :|.|   .|.|||.|....:|:.|.::..:|::.:|::.:.||
Zfish   540 AQYIEFSKPFKYQGLTILVKKEIPRS---TLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSP 601

  Fly   558 IEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQS-PDIYPRAMSTRIISSTWGFFSLIIVAS 621
            .....:|:.:.|.    :..:|:.:.||:.|..:... .:..||:.|.||:...|..|::|||||
Zfish   602 FGRFKVNSEEEEE----DALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVAS 662

  Fly   622 YTANLAAFLTTERMINPIENAED--LASQTE-ISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNK 683
            |||||||||..:|....|....|  |.:.:: ..|.|:...|...:||..|  ....::|.|:..
Zfish   663 YTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQV--ELSTMYRHMEKH 725

  Fly   684 KPSAFTTTYE---DGIKRVNQGN-YAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSP 744
                   .||   :.|:.|.... :||:.:|.:|::...:.|:|...|.|....|:||...|.||
Zfish   726 -------NYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSP 783

  Fly   745 WRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIV 809
            |:..:|||||...|.|.::.| ||.|....|..:|.|...     :|..|::.|||:::..||:.
Zfish   784 WKQNVSLAILSSHENGFMEDL-DKTWVRYQECDSRSNAPA-----TLTFENMAGVFMLVAGGIVA 842

  Fly   810 AAVVAFFEFWY 820
            ...:.|.|..|
Zfish   843 GIFLIFIEIAY 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	80/415 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	124/412 (30%)
		Lig_chan	532..806	CDD:459656	83/281 (30%)
grin1b	NP_001137603.1	PBP1_iGluR_NMDA_NR1	22..401	CDD:380602	81/426 (19%)
		PBP2_iGluR_NMDA_Nr1	413..815	CDD:270437	126/418 (30%)
		CaM_bdg_C0	851..879	CDD:402271	1/3 (33%)