Protein Alignment RunxA and runx2a

DIOPT Version :10

• Sequence 1: NP_001259747.1
• Gene: RunxA / 4379817
• FlyBaseID: FBgn0083981
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: NP_998023.1
• Gene: runx2a / 405784
• ZFINID: ZDB-GENE-040629-3
• Length: 467
• Species: Danio rerio
• Alignment Length: 498
• Identity: 165/498 - (33%)
• Similarity: 211/498 - (42%)
• Gaps: 163/498 - (32%)

  Fly    57 SNTEQNTPPTPAQLLNEAYTKMTSDILAE-------------RTLGDFLTEHPGELIRTSSPLFV 108
            |.:.:.:||:.:  |.....|| ||...|             ||:.:.:.:||.||:||.||.|:
Zfish    22 STSRRFSPPSSS--LQPVAGKM-SDAQPEPNAVVPRLRPHDNRTMVEIIADHPAELVRTDSPNFL 83

  Fly   109 CTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRF 173
            |:|||.|||.|||||||||||:|||:.|||:|||.|||||||.|||||.:||||||||:||||||
Zfish    84 CSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRF 148

  Fly   174 VGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPR------------------------ 214
            ||||||||||||||||.||||.:|||::|||||||||||||
Zfish   149 VGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLEDPPKPPLFSERLSELER 213

  Fly   215 -SKTMLSLLGQQQQFHFAFGQRPFHFS-------TDPLSGFRMPPIGNCQSASNTHWGYGSAASA 271
             .:|.:.:..|.|....:....|..|:       :||......||           |.|   ...
Zfish   214 LRQTTMRVAVQTQSPRPSLNATPNSFNPQGQTQISDPRQAQSSPP-----------WSY---EQP 264

  Fly   272 YSPYLA---SSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPD-----ST 328
            |.|||:   |..:.| |||.|                         :|....:|.:.|     |.
Zfish   265 YPPYLSQMTSPSIHS-TTPLS-------------------------STRATGLPTISDVPRRLSG 303

  Fly   329 ASDLD-------------QHLSSLVGSTSGQMTHHSLLGAGGQTSISSTVNGASGGGSAGAGTAG 380
            .|:|.             ..||||..|.......|.      ..:.:.|....:.|.|.|..|
Zfish   304 TSELSPFSADPRQFERQFPSLSSLTDSRFPSPRMHY------PATFTYTPTPVTSGMSLGMST-- 360

  Fly   381 GGAGSGGGAGGGAGGNSILVPRYHTNASNEY-NVHSSQNGPRSLSDS------------------ 426
                               ...|||.....| ....:|:||...|.:
Zfish   361 -------------------TTHYHTYLPPPYPGSTQNQSGPFQTSSTPYLYYGASSGSYQFPMVP 406

  Fly   427 --SQAESPVQEDLLTTNT------PNLGSTAGGGAANGGAGSN 461
              .::.|.:.....:.:|      |||.:...||.|:|...|:
Zfish   407 GGDRSPSRMLPPCTSASTGSTLINPNLPNQTDGGEADGSHSSS 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RunxA	NP_001259747.1	Runt	88..216	CDD:459963	98/152 (64%)
runx2a	NP_998023.1	Runt	63..191	CDD:459963	98/127 (77%)
		PHA03247	<222..458	CDD:223021	55/295 (19%)
		RunxI	376..467	CDD:430037	14/74 (19%)