Protein Alignment RunxA and RunxB

DIOPT Version :10

• Sequence 1: NP_001259747.1
• Gene: RunxA / 4379817
• FlyBaseID: FBgn0083981
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: NP_001259745.1
• Gene: RunxB / 33051
• FlyBaseID: FBgn0259162
• Length: 663
• Species: Drosophila melanogaster
• Alignment Length: 733
• Identity: 245/733 - (33%)
• Similarity: 325/733 - (44%)
• Gaps: 196/733 - (26%)

  Fly     4 TTTSSNSTASNANNNNNNTANNNNTSSNNNTTNTNGSSNNNTSGNNNNSSGNNSNTEQ-NTPPTP 67
            |||...:..|:|::||||  |||.:::|||.||.|   ||:|:.||||::.||..|:. :|.|
  Fly    42 TTTKRRNAESSASSNNNN--NNNTSTTNNNNTNNN---NNSTTNNNNNNNNNNVKTKPVDTSP-- 99

  Fly    68 AQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLG 132
                     .:|.:.|.|||:...|.||||||::|.||..|||.||.|||||||||:||||::||
  Fly   100 ---------YLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALG 155

  Fly   133 DIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIA 197
            ::||||:||:|||||||:|.|||||||||||||||||||||||||||||||||||.:||||..||
  Fly   156 EVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIVISTNPIQIA 220

  Fly   198 TYNKAIKVTVDGPREPRSKTMLSLLGQQQQFH-FAFGQRPFHFSTDPLSG---FRMPPIGNCQSA 258
            ||.||||||||||||||||.      :.|.|| ||||  |..|..|||..   |::|...:....
  Fly   221 TYTKAIKVTVDGPREPRSKV------RHQGFHPFAFG--PQRFGPDPLMAGLPFKLPGFAHHLVG 277

  Fly   259 SNTH-----W------GYGSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDF 312
            .::|     |      |...||...:|:.   |..:...||       |.|....|.|...:|
  Fly   278 MHSHLHAPDWRAHMALGGRPAAFTAAPFF---GHHAAAFPT-------ASGLRGLSGDSQQHQ-- 330

  Fly   313 GGATNRDCVPMLPDSTASDLDQHLSSLVGSTSGQMTHHSLLGAGGQTSISSTVNGASGGGSAGAG 377
                             ....||..:.||:.      ||.....|..:.::|     .|....|.
  Fly   331 -----------------QQQQQHQLATVGAA------HSTTSPEGSPTTTTT-----SGTQLSAF 367

  Fly   378 TAGGGAGSGGGAGGGAGGNSILVPRYHTNASNEYNVHSSQNGPRSLSDSSQAESPVQEDLLT-TN 441
            .......|               |...|:..::.|.::|.|.    :.||..::..:.|.:: |.
  Fly   368 VQPPMTSS---------------PPPVTSLQHDNNNNNSNNN----NSSSHIDAGFESDSISVTG 413

  Fly   442 TP--NLGS--------TAGGGAANGGAGSNAGSGAAGSGAGGAGGASSAVGNPAMLGANQNFPGI 496
            :|  :|||        ......|...|.:.|.....|..:...||....:.:.:..|:...|..:
  Fly   414 SPRKSLGSPLTHDEEEAEAEAEAEAEAEAEAEEAEVGGLSRNGGGIQGPLHSESSPGSGGAFTAL 478

  Fly   497 VNQAQHSAASAYG-----GGTGVVGGGHGSAAAAAAGCNGSLY---PVLPAS--LLYSQLYTAAN 551
            :.::..:....:|     ||......||....|.||    .|:   |:||.|  .||:|||
  Fly   479 IQRSGKNPTELFGGFAAAGGNHFAPSGHSFNPALAA----QLFLQSPLLPQSSQWLYTQLY---- 535

  Fly   552 QSAHGFHSHTLP------AHASPNSSVHGELQSVMDHISNVGVRQQHNIMAGGGVTHPGDLTLIG 610
                |.:| .||      |.|:.|.:...|         |.|:..     .|....|.| :.||.
  Fly   536 ----GSYS-DLPWLRNAAAAAAANINPGQE---------NSGIPP-----LGSNPDHDG-VNLIK 580

  Fly   611 NCGASVR----NIEDGNSNRQVAALAAHR------------------------GHHNPTDNGGS- 646
            .|...:.    :.|:.|.|......:..|                        ||......||:
  Fly   581 RCVTLITHNPPDAENANPNASPPVSSTRRSPSPVETIDLDDVSTTSRSASGSSGHGGGVGGGGAV 645

  Fly   647 -------------VWRPY 651
                         |||||
  Fly   646 GPIRTRTPKPSADVWRPY 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RunxA	NP_001259747.1	Runt	88..216	CDD:459963	101/127 (80%)
RunxB	NP_001259745.1	Runt	115..239	CDD:459963	101/123 (82%)