Protein Alignment RunxA and Runx2

DIOPT Version :10

• Sequence 1: NP_001259747.1
• Gene: RunxA / 4379817
• FlyBaseID: FBgn0083981
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: NP_033950.2
• Gene: Runx2 / 12393
• MGIID: 99829
• Length: 528
• Species: Mus musculus
• Alignment Length: 589
• Identity: 195/589 - (33%)
• Similarity: 243/589 - (41%)
• Gaps: 190/589 - (32%)

  Fly    86 RTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENY 150
            ||:.:.:.:||.||:||.||.|:|:|||.|||.|||||||||||:||::.|||:|||.|||||||
Mouse   107 RTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENY 171

  Fly   151 CAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPR- 214
            .|||||.:||||||||:||||||||||||||||||||||.||||.:|||::|||||||||||||
Mouse   172 SAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRR 236

  Fly   215 -------SKTMLSLLGQQQQFHFAFGQRPFHFSTDPLSGFR--MPPIGNCQSASNTHWGYGSAAS 270
                   ||..|            |..|.......|....|  :||       .|......||.|
Mouse   237 HRQKLDDSKPSL------------FSDRLSDLGRIPHPSMRVGVPP-------QNPRPSLNSAPS 282

  Fly   271 AYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTASDLDQH 335
            .::|    .|.|..|.|..||.:.|      .|.||                    |..|.|.|.
Mouse   283 PFNP----QGQSQITDPRQAQSSPP------WSYDQ--------------------SYPSYLSQM 317

  Fly   336 LSSLVGSTSGQMTHHSLLGAGGQTSISSTVNGASGGGSAGAGTAGGGAGSGGGAGGGAGGNSIL- 399
            .|..:.||               |.:|||                          .|.|..:|.
Mouse   318 TSPSIHST---------------TPLSST--------------------------RGTGLPAITD 341

  Fly   400 VPRYHTN---ASNEYNVHSSQNGPRSLSDSSQAESPVQEDLLTTNTPNLGSTAGGGAANGGAGSN 461
            |||..::   |::::.:     .|.|||..|||                      ||:..|..|:
Mouse   342 VPRRISDDDTATSDFCL-----WPSSLSKKSQA----------------------GASELGPFSD 379

  Fly   462 AGSGAAGSGAGGAGGASSAVGNPAMLGANQNFPGIVNQAQHSAASAYGGGTGVVGGGHGSAAAAA 526
            .....:.|..     ..|...||.|     ::|         |...|   |..|..|.....:|.
Mouse   380 PRQFPSISSL-----TESRFSNPRM-----HYP---------ATFTY---TPPVTSGMSLGMSAT 422

  Fly   527 AGCNGSLYPVLPASLLYSQLYTAANQSAHG-FHSHTLPAHASPNSSVHGELQSVMDHISNVGVRQ 590
            ...:..|.|..|.|          :||..| |.:.:.|......||...:..
Mouse   423 THYHTYLPPPYPGS----------SQSQSGPFQTSSTPYLYYGTSSASYQFP------------- 464

  Fly   591 QHNIMAGGGVTHPGDL----TLIGNCGASVRNIEDGNSNRQVAALAAHRGHHNPTDNGG----SV 647
                |..||...|..:    |...| |:::.|....|.|..|.|..:|.......::.|    ||
Mouse   465 ----MVPGGDRSPSRMVPPCTTTSN-GSTLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMDESV 524

  Fly   648 WRPY 651
            ||||
Mouse   525 WRPY 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RunxA	NP_001259747.1	Runt	88..216	CDD:459963	97/135 (72%)
Runx2	NP_033950.2	Runt	109..237	CDD:459963	97/127 (76%)
		Herpes_BLLF1	<273..488	CDD:282904	73/362 (20%)
		RunxI	437..528	CDD:430037	25/108 (23%)