DRSC/TRiP Functional Genomics Resources

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Protein Alignment Thd1 and Tdg

DIOPT Version :9

Sequence 1:NP_001259060.1 Gene:Thd1 / 43796 FlyBaseID:FBgn0026869 Length:1738 Species:Drosophila melanogaster
Sequence 2:NP_766140.2 Gene:Tdg / 21665 MGIID:108247 Length:421 Species:Mus musculus


Alignment Length:451 Identity:168/451 - (37%)
Similarity:232/451 - (51%) Gaps:80/451 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   626 SEGTRCSSHASVVDPYSFMGEELHMHSPSHRHLDAVTTGPGRYGILVSNDTPECLSREMYRHSQQ 690
            :|..|..|...|...|||..:::....|:.    |||||                 :::...:..
Mouse     3 AEAARSYSLEQVQALYSFPFQQMMAEVPNM----AVTTG-----------------QQVPAVAPN 46

  Fly   691 STTVLEQTDSSSCGINFKP---MPKKRGRKKKLVAVNADTSQMTTPVDQQKVSAGRADCEDGGGD 752
            ..||.||.......:. :|   .||:|.||.:       .::...||:.:|    .|..:..|..
Mouse    47 MATVTEQQVPEDAPVQ-EPAPEAPKRRKRKPR-------AAEPQEPVEPKK----PATSKKSGKS 99

  Fly   753 QAAKPKERK---------KHDRFNGMSEEEVIKRTIPDHLCDNLDIVIVGINPGLFAAYKGHHYA 808
            ..:|.|:.|         |.|||||:||.|::.:|:||.|..||||||:||||||.||||||||.
Mouse   100 TKSKEKQEKITDAFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYP 164

  Fly   809 GPGNHFWKCLYLAGLTQEQMSADEDHKLI-KQGIGFTNMVARATKGSADLTRKEIKEGSRILLEK 872
            ||||||||||:::||::.|::..:||.|. |.||||||||.|.|.||.||:.||.:||.|||::|
Mouse   165 GPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQK 229

  Fly   873 LQRFRPKVAVFNGKLIFEVFSGK------KEFHFGRQPDRVDGTDTFIWVMPSSSARCAQLPRAA 931
            ||:::|::||||||.|:|:||.:      |...||.||.::..|:|..:|||||||||||.|||.
Mouse   230 LQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQ 294

  Fly   932 DKVPFYAALKKFRDFLNGQIPHIDESECVFTDQRIRLCSAQQQVDIVGKINKTHQP--------P 988
            |||.:|..||..||.|.|...:.|..|..:|   ..|..||:....:....:.:.|        .
Mouse   295 DKVHYYIKLKDLRDQLKGIERNADVQEVQYT---FDLQLAQEDAKKMAVKEEKYDPGYEAAYGGA 356

  Fly   989 LGDHPSSLTVVSNCSGPIAGDAECGIVAEE---------SDQVQSEKMIPQMDPTVPSSSN 1040
            .|::|        |:|...|.|..|:.|..         ||....:.|.......:||.:|
Mouse   357 YGENP--------CNGEPCGIASNGLTAHSAEPRGEAAPSDVPNGQWMAQSFAEQIPSFNN 409

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Thd1NP_001259060.1 UDG_like 714..962 CDD:294330 129/263 (49%)
TdgNP_766140.2 mug 2..340 CDD:273154 153/372 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 45..108 17/74 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167849295
Domainoid 1 1.000 193 1.000 Domainoid score I3201
eggNOG 1 0.900 - - E1_COG3663
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006159
OrthoInspector 1 1.000 - - oto93070
orthoMCL 1 0.900 - - OOG6_104831
Panther 1 1.100 - - LDO PTHR12159
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1493
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
109.730

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