DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Thd1 and Tdg

DIOPT Version :9

Sequence 1:	NP_001259060.1	Gene:	Thd1 / 43796	FlyBaseID:	FBgn0026869	Length:	1738	Species:	Drosophila melanogaster
Sequence 2:	NP_766140.2	Gene:	Tdg / 21665	MGIID:	108247	Length:	421	Species:	Mus musculus

Alignment Length:	451	Identity:	168/451 - (37%)
Similarity:	232/451 - (51%)	Gaps:	80/451 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   626 SEGTRCSSHASVVDPYSFMGEELHMHSPSHRHLDAVTTGPGRYGILVSNDTPECLSREMYRHSQQ 690
            :|..|..|...|...|||..:::....|:.    |||||                 :::...:..
Mouse     3 AEAARSYSLEQVQALYSFPFQQMMAEVPNM----AVTTG-----------------QQVPAVAPN 46

  Fly   691 STTVLEQTDSSSCGINFKP---MPKKRGRKKKLVAVNADTSQMTTPVDQQKVSAGRADCEDGGGD 752
            ..||.||.......:. :|   .||:|.||.:       .::...||:.:|    .|..:..|..
Mouse    47 MATVTEQQVPEDAPVQ-EPAPEAPKRRKRKPR-------AAEPQEPVEPKK----PATSKKSGKS 99

  Fly   753 QAAKPKERK---------KHDRFNGMSEEEVIKRTIPDHLCDNLDIVIVGINPGLFAAYKGHHYA 808
            ..:|.|:.|         |.|||||:||.|::.:|:||.|..||||||:||||||.||||||||.
Mouse   100 TKSKEKQEKITDAFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYP 164

  Fly   809 GPGNHFWKCLYLAGLTQEQMSADEDHKLI-KQGIGFTNMVARATKGSADLTRKEIKEGSRILLEK 872
            ||||||||||:::||::.|::..:||.|. |.||||||||.|.|.||.||:.||.:||.|||::|
Mouse   165 GPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQK 229

  Fly   873 LQRFRPKVAVFNGKLIFEVFSGK------KEFHFGRQPDRVDGTDTFIWVMPSSSARCAQLPRAA 931
            ||:::|::||||||.|:|:||.:      |...||.||.::..|:|..:|||||||||||.|||.
Mouse   230 LQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQ 294

  Fly   932 DKVPFYAALKKFRDFLNGQIPHIDESECVFTDQRIRLCSAQQQVDIVGKINKTHQP--------P 988
            |||.:|..||..||.|.|...:.|..|..:|   ..|..||:....:....:.:.|        .
Mouse   295 DKVHYYIKLKDLRDQLKGIERNADVQEVQYT---FDLQLAQEDAKKMAVKEEKYDPGYEAAYGGA 356

  Fly   989 LGDHPSSLTVVSNCSGPIAGDAECGIVAEE---------SDQVQSEKMIPQMDPTVPSSSN 1040
            .|::|        |:|...|.|..|:.|..         ||....:.|.......:||.:|
Mouse   357 YGENP--------CNGEPCGIASNGLTAHSAEPRGEAAPSDVPNGQWMAQSFAEQIPSFNN 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Thd1	NP_001259060.1	UDG_like	714..962	CDD:294330	129/263 (49%)
Tdg	NP_766140.2	mug	2..340	CDD:273154	153/372 (41%)
Tdg	NP_766140.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..108		17/74 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849295
Domainoid	1	1.000	193	1.000	Domainoid score	I3201
eggNOG	1	0.900	-	-		E1_COG3663
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006159
OrthoInspector	1	1.000	-	-		oto93070
orthoMCL	1	0.900	-	-		OOG6_104831
Panther	1	1.100	-	-	LDO	PTHR12159
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1493
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.730