Protein Alignment zfh2 and zfhx3a

DIOPT Version :10

• Sequence 1: NP_524623.2
• Gene: zfh2 / 43795
• FlyBaseID: FBgn0004607
• Length: 3005
• Species: Drosophila melanogaster
• Sequence 2: XP_692222.4
• Gene: zfhx3a / 563768
• ZFINID: ZDB-GENE-050309-237
• Length: 3356
• Species: Danio rerio
• Alignment Length: 3636
• Identity: 814/3636 - (22%)
• Similarity: 1211/3636 - (33%)
• Gaps: 1504/3636 - (41%)

  Fly     5 DVETFNGKIVYNLDGSAHIIATDNTNGGGSGSGQNCYGSTTNSLKNLSKDKGRGQEEKDIEHPSQ 69
            |||...|:|:|..||||:::.:..|:|..|.|    .|:.|:.::
Zfish   108 DVERPIGEILYQPDGSAYVMDSKLTSGAPSSS----LGAPTSIIR-------------------- 148

  Fly    70 YHREQSDNKRQEEAVDNRPGVESLGSACYKS---SPKIHSFRVVSAQ---DANS----TCQDQIR 124
                                      .|:.|   ||....|||....   |::|    |||.:..
Zfish   149 --------------------------TCFISLSQSPTPQIFRVFQLHNLGDSDSLALMTCQSKDS 187

  Fly   125 AFKI-------------QKPILMCFICKLSFGNVKSFSLHANTEHRLNLEELDQQLLNREYSSAI 176
            ...:             .|||||||:|:||||...||..||:.:|.:...:.:|.||..:::|||
Zfish   188 TPDVAGSSETGVMWSGPPKPILMCFLCRLSFGRSHSFRAHASVQHNITFSDEEQHLLLFKHASAI 252

  Fly   177 IQ-RNMDEKPQISFLQPLAN-------NDASADT-NDTEKLQTATEGSD--------ATLPSSPQ 224
            :| ......|.:.||:|..|       |.||::: |.||......|.::        :.|||.|:
Zfish   253 LQPAGPGNLPLLCFLKPKRNCESVVPLNLASSNSVNSTENTARRKENTEPLTSKPGLSLLPSPPR 317

  Fly   225 ---------PVFRNVSELEPENKQETEQNRLLNQDREQEPESDQHTSSSKMAAPSAYIPLSSPKV 280
                     |. ::.|.|..|..|..:... :.:|.|...|.::
Zfish   318 TSPATSVPSPA-KDPSTLGREGTQRGKVEE-IRKDGESSEEGER--------------------- 359

  Fly   281 AGKLTVKFGSLNSATAKTNNLSKVSSTSSPPSTYASGEVLSPSTDNISNHKSTHCNQE-TEPPSS 344
              :|.::.||    |...|:...:||:|.  ..:.:...||              ||. ::||:|
Zfish   360 --RLCLEVGS----TVDCNSAHSISSSSG--QEHITEAALS--------------NQSISKPPNS 402

  Fly   345 SSSEVEMKIGSMSTSPQTNDSDVPCSGFLQMQHMTTGGAYTPQVSSFHASLAALAANESNDNRVK 409
                |.:....|:.:....||:..|.        |:...:.|      |..:.:..|.|
Zfish   403 ----VTIATSFMNNTKTLTDSESECG--------TSFNCHDP------APASLVVVNPS------ 443

  Fly   410 LITEFLQQQLQQHQSSLFPSPCPDHPDLNGVDCK-TCELLDIQQR----SKSPSSSHHQFSQSL- 468
              |....:||...:|:....|.....:.:.:..: |..|.:..:|    |..|::..|..|.:|
Zfish   444 --TVTTTEQLANQESATATKPNDQLENGSAIAIEPTASLSEDDRRAVTHSDLPNNHSHSMSPTLS 506

  Fly   469 PQLQIQSQPQQTPHRSPCSNSVALPVSPSASSVASVGNASTATSSFTIGACSEHINGRPQGVDCA 533
            |.|...:||......|..::...|.|:.....||:..:|..::.||:|.|...|
Zfish   507 PTLPQTTQPILEEGHSDTASRGRLVVASDGGFVAAGDDAQGSSYSFSIQASLAH----------- 560

  Fly   534 RCEMLLNSARLNSGVQMSTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGES-ACGYCLAGQQ 597
                              |||||||||||:||||||||:|||.||:||||:.|: .|.||.:||.
Zfish   561 ------------------TRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPESETEQCPYCSSGQS 607

  Fly   598 HPRLARGESYSCGYKPYRCEICNYSTTTKGNLSIHMQSDKHLNNMQELNSSQNMVAAAAAAAVTG 662
            ||||||||:|||||||:||::|.|||||||||||||||||||||||.|
Zfish   608 HPRLARGETYSCGYKPFRCQVCQYSTTTKGNLSIHMQSDKHLNNMQSL----------------- 655

  Fly   663 KLLLSSSSPQVTAACPSNSGSGAGSGSSNIVGGTASLSGNATPSVTGANSSNANAGSNTNNAGTK 727
                 .|.||..|..|:...:..          |.||     |::|  :.:.||:.|.:...|
Zfish   656 -----QSQPQPHAHSPAPQPNPL----------THSL-----PTLT--HPTRANSPSPSKLRG-- 696

  Fly   728 PKPSFRCDICSYDTSVARNLRIHMTSEKHTHNMAVLQNNIKHIQAFNFLQQQQQSGTGNIASHSS 792
             :.|:||::|.|:|:|||||||||||||||||:.:||.|:.|      :|:|::.....:..|.
Zfish   697 -RASWRCEVCDYETNVARNLRIHMTSEKHTHNVLLLQQNLAH------MQRQRKHNASELFRHC- 753

  Fly   793 GSFMPEVALADLAYNQALMIQLLHQQQQHQQSANTKLSPSSSPVSTPDQFSFSPKPIKLNHGTGA 857
                                    |.|.....|.|.||
Zfish   754 ------------------------QPQSQLPDAITSLS--------------------------- 767

  Fly   858 AMGIGMAMGMGMSHSNEVSCELSGDPHPLTKTDKWPMAFYSCLVCDCYSTNNLDDLNQHLLLDRS 922
                          .:|.|.:                ..:.|::|..:|.:.|::|:|||.:.||
Zfish   768 --------------CHETSSQ----------------KLFECILCGRFSCDTLEELSQHLTMQRS 802

  Fly   923 RQSSSASSEIMVIHNNNYICRLCNYKTNLKANFQLHSKTDKHLQKLNFINHIREGGPQ----NEY 983
            ..||...|.....|:    ||||:|.|.|:||||||.:||||:|:.....|:||...|    .|.
Zfish   803 LPSSYWRSTTGDTHH----CRLCHYATPLRANFQLHCQTDKHVQRYQLAAHLREASSQQGNIEEE 863

  Fly   984 KMQYQQQQLAA-NVVQLKCNCCDFHTNSIQKLSLHTQQMRHDTMRMIFQHLLYIVQQSEMHNKSS 1047
            :.:::.:.:|| :.|||:||.||:..:|::||.|||...||:|...::::|
Zfish   864 EEEWRLRCVAAGSQVQLRCNACDYKASSLEKLKLHTMNTRHETSLRLYKYL-------------- 914

  Fly  1048 GSAEDDPQCACPDEDQQLQ-LQSSKKLLLCQLCNFTAQNIHEMVQHVKGIRHLQVEQFICLQRRS 1111
                           |||. |:|....|.|.||:|:.|:...:|||...:.|.:.|..:.|||..
Zfish   915 ---------------QQLDGLESEDVWLHCVLCDFSTQSSLSLVQHSHSLSHQRGEGLLRLQRIQ 964

  Fly  1112 EN-QEIPALNEVFKVTEW-VMENEDVSLAPGLNLARTTTNDATTDASYAAASSAAVPAIPDVSMF 1174
            :. |:...|..:|.:.:. ..||.|::                                   .|.
Zfish   965 KGLQDEEELGAIFTIRKSPAQENGDMN-----------------------------------GMD 994

  Fly  1175 SPTSPSSCATSCDKNLSQIVLPNVNNLGSGVPTTVFKCNLCEYFVQSKSEIAAHIETEHSCAESD 1239
            |||..|:                  |...|        |.....:..|||  ..||||   ||.:
Zfish   995 SPTEVSA------------------NQEDG--------NKHGELMGKKSE--GIIETE---AEQN 1028

  Fly  1240 EFITIPTNTAALQAFQTAVAAAALAAVHQRCAVINPPTQDTVDEDKDLDTNVSDGPVGIKQERLE 1304
            |..:.|...::                                     .:..||.....||.|::
Zfish  1029 ESSSSPKRPSS-------------------------------------GSEESDEASPCKQPRMQ 1056

  Fly  1305 QEVD-----RTTSMDVTKDLASQATDFGAPESPKVAETEVGVQCPLCLENHFREKQYLEDHLTSV 1364
            :|:.     |....|:.: |.|...:..|        .:..::|||| ::.......|..|||.:
Zfish  1057 EEMRQCPFCRFRHNDIER-LRSHVMNQHA--------VQPSLRCPLC-QDTLHSIALLRTHLTHL 1111

  Fly  1365 HSVTRDGLSRLLLLVDQKALKKESTDIACPTDKAPYANTNALERAPTPIENTCNVSLIKSTSANP 1429
            ||||.|...:|:..|....:..|...:..........|.|..:|....|          :..|.|
Zfish  1112 HSVTADCTQKLINTVIASDVLPEKMFLPVHNSDTQPINANEAKRLDDEI----------TADAEP 1166

  Fly  1430 SQSVSLQGLSCQQCEAS--FKHEEQLLKHAQQNQHFSLQNGEYLCLAASHISRPCFMTFRTIPTM 1492
            .:..:      ...|||  :|...:..:..::|      |..:.|.     .:.|...|.:...:
Zfish  1167 ERGTT------PHLEASKIYKQPSEDAESTKEN------NAAFPCW-----HKGCNKVFTSSSAL 1214

  Fly  1493 ISHFQDLH---MSLIISERHVYKYRCKQCSLAFKTQEKLTTHMLYHSMRDATKCSFCQRNFRSTQ 1554
            .:||..:|   ....||:||:|||||.||||||||.|||..|..||::|.||.|..|||:||:.|
Zfish  1215 QTHFNQIHSQKSQTAISDRHIYKYRCNQCSLAFKTPEKLQLHSQYHAIRAATMCCLCQRSFRTMQ 1279

  Fly  1555 ALQKHMEQAHAE-----------------------DGTPSTRTNSPQTPMLSTEE---------- 1586
            ||:||:|.:|.|                       |.|......|.:...|..||
Zfish  1280 ALRKHLETSHLELSEAQIQQLYGGLMMNGESLISGDQTFGEEEGSSEEGGLKDEEECDLEEKLSP 1344

  Fly  1587 --------------------------------------------------THKHLL-----AESH 1596
                                                              |.|::|     :.||
Zfish  1345 TDNDSIVVKDNVECDSKQPVLPLRKGPNITMEKFLDPSRPFKCTVCKESFTQKNILLVHYNSVSH 1409

  Fly  1597 -------------AVEREVSGSDVSPIE-------------LETHL------------------N 1617
                         .::..|:.:|..|.:             ||.|:                  :
Zfish  1410 LHKLKRSLQDTPTGLQEPVTNTDNKPFKCSICNVAYSQSSTLEIHMRSVLHQTKARASKVDSSTS 1474

  Fly  1618 KET------RHLSPTPMSLDSQSHQKHLATFAALLKQQQCNSDAGG--LHPEALSMSTGEMPPQL 1674
            .|:      :.||.||:|:.|.:...:    ..|..||  |:|..|  .:|:....||.::..:|
Zfish  1475 SESVGPPPGKALSSTPVSMKSATPMNN----GGLSHQQ--NTDLNGTPANPDTSHPSTSDVRKKL 1533

  Fly  1675 --------------------QGLQNLQ--------HIQQ-----------HFGAVAAAAGLPINP 1700
                                |.||..|        |:||           |....|.....|:..
Zfish  1534 VTMIDSASKQQQVSLQQQQQQSLQQQQQQLAQAQAHLQQELQKKAALLQSHLFNPALLHPFPMAT 1598

  Fly  1701 VDMLNIMQFHHLM---------------------SLNFMNLAP---------------------- 1722
            ..:|.:.|...|:                     .||...:.|
Zfish  1599 EALLPVQQQQQLLLPFLIPGGEFRMNPEVSLKGSGLNLSTIMPTVNQDITEASKNDGAKYTSKQK 1663

  Fly  1723 --------PLV-----------------------------FGAN--------------------- 1729
                    |.:                             .|||
Zfish  1664 QNEDLAIHPEITEQKLRSDSQCENDKDGQKSNERSTEIDNVGANEKPPPKTNENEDLNKNKSTSS 1728

  Fly  1730 -----------AAGNAVSG---------------------------------------------- 1737
                       |.|||...
Zfish  1729 DEFLPPRISHDAPGNASKALLENFGFEIVMQFNENRQRYQKNLTEPIPNVGDVPDTKEVDHSEDV 1793

  Fly  1738 -----------------------------------------------------PSALNNSITTST 1749
                                                                 |:...:|..||.
Zfish  1794 EKLECKSCRKLFSNALILKSHKEQIHHSIFPIKSLEKFAKDYREQYDKLFPLRPTTPEDSPVTSP 1858

  Fly  1750 ATS---------------------ASGLGDTHLTSGVSSI------------------------- 1768
            :.|                     .|.|..|..|..:..:
Zfish  1859 SPSPPVIPNPSVQQPQQPVQPIIAPSTLSATPTTVSIPQVKTPLAQISIPMELPLFPPLLMPPIP 1923

  Fly  1769 -------------PVDSGKATAVPPQTQL-NANANSQQLASNQKRARTRITDDQLKILRAHFDIN 1819
                         |||:|   ..|..||| ........|....||.|||||||||::||.:||||
Zfish  1924 LQALTPPVPVHLPPVDAG---LTPDLTQLYQQQLTPAMLQQQSKRPRTRITDDQLRVLRQYFDIN 1985

  Fly  1820 NSPSEESIMEMSQKANLPMKVVKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYERTGQAKV 1884
            |||:|:.|.||:.|:.||.||:||||||||||||||||||||||:|||.|||
Zfish  1986 NSPNEDQIHEMANKSGLPHKVIKHWFRNTLFKERQRNKDSPYNFSNPPITTL------------- 2037

  Fly  1885 TPLNDTCSVAVTGPMTSSTISLPPSGNINLSSKENATSKVLAAGKANASGPVTFSATVPVSTPLS 1949
                                                                             
Zfish  2038 ----------------------------------------------------------------- 2037

  Fly  1950 RPESTNSSGNISDYIGNNIFFGQLGSKEQILPYSLDGQIKSEPQDDMIGATDFAYQTKQHSSFSF 2014
                                                        ||:
Zfish  2038 --------------------------------------------DDV------------------ 2040

  Fly  2015 LKQQQDLVDPPEQCLTNQNADTAQDQSLLAGSSLASNCQSQQQINIFETKSESGSSDVLSRPPSP 2079
                                                                    .|.||||||
Zfish  2041 --------------------------------------------------------KVDSRPPSP 2049

  Fly  2080 NSGAAGNVYGSMNDLLNQQLENMGSNMGPPKKMQIVGKTFEKNVAPMVTSGSVSTQFESNSSNSS 2144
                         :|..|:.
Zfish  2050 -------------ELPRQEF--------------------------------------------- 2056

  Fly  2145 SSSSSTSGGKRANRTRFTDYQIKVLQEFFENNSYPKDSDLEYLSKLLLLSPRVIVVWFQNARQKQ 2209
                  .||||::||||.|||::|||:||:.|:||||.:.|.||.||.||.|||||||||||||.
Zfish  2057 ------YGGKRSSRTRFNDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLSTRVIVVWFQNARQKA 2115

  Fly  2210 RKIYENQ-------PNNTLFENEETKKQNINYACKKCNLVFQRYYELIRHQKNHCFKEENNKKSA 2267
            ||.||||       ....|..:...:..|.|:.|||||:||||.::||.|||..|:|:::.:...
Zfish  2116 RKNYENQGEGGKESERRDLSNDRYFRTSNNNFQCKKCNIVFQRIFDLINHQKKQCYKDDDEELQN 2180

  Fly  2268 KAQIAAAQIAQNLSSEDSNSSMDIHHVGICPPGSAVAS------------------------HTL 2308
            .....|.:..::||.....|.:........|..|:|:|                        .|.
Zfish  2181 SLNETAGEYQESLSPISGPSCLTQATSCSSPSSSSVSSTNVKATDSEHKNTTSVYGELKQTNETS 2245

  Fly  2309 STPGSAAPLPGQYTQHSFGALPSPQHLFAKSSSLTD----------------------------- 2344
            |.|..|..:..:: :.:...:..|:.|..::.|::.
Zfish  2246 SEPKQAVSINCEF-KDTENRMQQPKPLCEENQSISTEIQSHSSPKQQKISCTASETNPAPSQSSQ 2309

  Fly  2345 --FSPSTTPTPPQRERSNSLDQIQRPPKFDCDKCELNFNQLEKLREHQLLH-------------- 2393
              |||..||...|::: ..|.|...|  ::|.:|:|:|...|..:|||.:|
Zfish  2310 KIFSPLETPVSEQQQQ-QKLSQDMSP--YNCIQCKLSFPSFEHWQEHQQMHFLTQSYFPTPPFLD 2371

  Fly  2394 --------LMNPGN-------ICSDVGQN-SNPEANFGPFGSILQSLQQAAAQQQ---------Q 2433
                    |.:|.|       :...:.|. :||.|......|.:.||::...::.         :
Zfish  2372 RSVDMPLMLFDPANPLLARHLLSGTLSQMVANPPAVTSITDSTINSLKRKLEEKAGSSSVENDWE 2436

  Fly  2434 QHHQQPPTKKR---------------KYSDCSSNADEMQSLSELEASQKKHEYLYKYFMQNETSQ 2483
            .:..:|...||               ||...|:...:|......|...||.  :.:.:.||..::
Zfish  2437 NNGDEPHRDKRMRTTITPEQLEVLYQKYLLDSNPTRKMLDHISNEVGLKKR--VVQVWFQNTRAR 2499

  Fly  2484 EVKQQF--LMQQQQKKLEQGNECDF------ELDFLTNFYQQNELKKVSNYDFLLQYYRTHEEAK 2540
            |.|.||  |...|..:     .|.|      ....|....:.....:..|..:.:        |.
Zfish  2500 ERKGQFRALGPSQIHR-----RCPFCRALFKAQTALAAHIRSRHWHEARNAGYSM--------AM 2551

  Fly  2541 SSQQHTFSSS--KKPTIEFLLQYYQLNESKKFFQLVASPQIIPDVPGYKPSLRIPKSTSDEAPYI 2603
            ||..|....|  |....:|......||                              ::|:|..:
Zfish  2552 SSMGHEQEGSPVKSDLFDFATYSQYLN------------------------------STDDADSL 2586

  Fly  2604 GETSLEQATELQR------------EKQDEQLRIDRPSEENDLSMNKNKVENINNNNINVDQSNL 2656
            ...|::.::..||            |.:...:.:.:..|::.|:.::... |..:::.|.:.::.
Zfish  2587 ACKSIDLSSHQQRLSPKPIKGECMEEFEMPSMSVYQTFEQSKLNSHEANT-NTTHDHTNDEGNDS 2650

  Fly  2657 TETNGGVPSVETKEECTQESSLIAMDDENKYLCTRSKQKDDKEKSHYL-----HNLEDFLDATMI 2716
            .|...|  |:|.....|:..:              |.:.|:|..|..:     .|.:| ||..:.
Zfish  2651 LEAQHG--SIEHMSPSTEREA--------------SSESDEKMSSGLVSPAMSFNAKD-LDNELF 2698

  Fly  2717 ENNSQTLTFNDDEKACQKDELTQNSNAIEKRSSVSPVNVSSKQNKRLRTTILPEQLNFLYECYQS 2781
            .:.|:..:..|....|.....:||            .:......||.||.:...|:..|..|:..
Zfish  2699 LDYSENSSLADPASPCPGSSNSQN------------FDYDRHNQKRYRTQMSNLQVKVLKACFSD 2751

  Fly  2782 ESNPSRKMLEEISKKVNLKKRVVQVWFQNSRAKDKKSRNQRHYAHISDDNSYDGSSGKEVYSDLR 2846
            ...|:....|.:...:.|.||||||||||:|||:||::                       ..|.
Zfish  2752 YKTPTMLECEALGNDIGLAKRVVQVWFQNARAKEKKAK-----------------------LSLA 2793

  Fly  2847 SNGITVDTDLETNLQDCQLCQV---TQVNIRKHAFSVEHISKMKKLLEQTTELYAQSNGSGSEDN 2908
            ....|..|.::....:|.||.|   :.::||.|.||.:|::|:|:.|....|...:..||.| ..
Zfish  2794 KQFGTESTSIDRPKTECTLCSVKYSSSLSIRDHVFSQQHLAKVKEALGGQMERDREYLGSVS-TR 2857

  Fly  2909 DSDREKRFYNLSK-AFLLQHV----VTNATSHAIHTARQDSDVIA-EGNCILNYDTNGGDS 2963
            ....::....|.| :.:|.||    :......|:|...|.|.... :..||.|  |..|.|
Zfish  2858 QLMAQQELEQLKKTSDVLGHVQPQAILGLNQTALHCLSQSSMYSGLQAQCIAN--TPSGSS 2916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zfh2	NP_524623.2	C2H2 Zn finger	561..581	CDD:275368	15/19 (79%)
		C2H2 Zn finger	616..633	CDD:275368	13/16 (81%)
		C2H2 Zn finger	1515..1542	CDD:275371	17/26 (65%)
		C2H2 Zn finger	1543..1564	CDD:275371	12/20 (60%)
		Homeodomain	1798..1857	CDD:459649	43/58 (74%)
		Homeodomain	2155..2211	CDD:459649	38/55 (69%)
		Homeodomain	2761..2817	CDD:459649	23/55 (42%)
zfhx3a	XP_692222.4	C2H2 Zn finger	570..591	CDD:275368	16/20 (80%)
		C2H2 Zn finger	626..643	CDD:275368	13/16 (81%)
		C2H2 Zn finger	1202..1222	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1240..1260	CDD:275368	13/19 (68%)
		C2H2 Zn finger	1268..1287	CDD:275368	11/18 (61%)
		C2H2 Zn finger	1387..1411	CDD:275368	5/23 (22%)
		C2H2 Zn finger	1438..1456	CDD:275368	3/17 (18%)
		HOX	1963..2019	CDD:197696	39/55 (71%)
		Homeodomain	2061..2117	CDD:459649	38/55 (69%)
		COG5576	2413..2542	CDD:227863	24/135 (18%)
		Homeodomain	2446..2502	CDD:459649	12/57 (21%)
		Homeodomain	2731..2787	CDD:459649	23/55 (42%)