Protein Alignment zfh2 and ZFHX3

DIOPT Version :10

• Sequence 1: NP_524623.2
• Gene: zfh2 / 43795
• FlyBaseID: FBgn0004607
• Length: 3005
• Species: Drosophila melanogaster
• Sequence 2: XP_054236368.1
• Gene: ZFHX3 / 463
• HGNCID: 777
• Length: 3704
• Species: Homo sapiens
• Alignment Length: 3736
• Identity: 856/3736 - (22%)
• Similarity: 1230/3736 - (32%)
• Gaps: 1555/3736 - (41%)

  Fly     5 DVETFNGKIVYNLDGSAHII--ATDNTNGG---GSGSGQNCYGST-TNSLKNLSKDKGRGQEEKD 63
            |||...|:|||..||||:|:  .:..|.||   |||||.....|. .|||      .|.|.::.|
Human   125 DVENLAGEIVYQPDGSAYIVESLSQLTQGGGACGSGSGSGPLPSLFLNSL------PGAGGKQGD 183

  Fly    64 IEHPS-----------QYHREQSDNKRQEEAVDNRPGVESLGSACYKSSPKIHSFRVVSAQ---- 113
               ||           .:|...|..|..|......|...:|...    ||.:|||||...:
Human   184 ---PSCAAPVYPQIINTFHIASSFGKWFEGPDQAFPNTSALAGL----SPVLHSFRVFDVRHKSN 241

  Fly   114 --------DANSTCQ-------------DQIRAFKIQKPILMCFICKLSFGNVKSFSLHANTEHR 157
                    .|.|:|.             |....:..:|||||||:||||||.|:||..||..:||
Human   242 KDYLNSDGSAKSSCVSKDVPNNVDLSKFDGFVLYGKRKPILMCFLCKLSFGYVRSFVTHAVHDHR 306

  Fly   158 LNLEELDQQLLNREYSSAIIQR-NMDEKPQISFLQPLANNDASADTNDTEKL------------Q 209
            :.|.|.::::|:.:..|||||. ..|::|.:|||:| .|.:.......|..|            .
Human   307 MTLSEDERKILSNKNISAIIQGIGKDKEPLVSFLEP-KNKNFQHPLVSTANLIGPGHSFYGKFSG 370

  Fly   210 TATEGSDATLPSSPQPVFRNVSELEPENKQE--TEQNRLLNQDREQEPESDQHTSSSKMAAPSAY 272
            ...||.:| ||:.        |...||..|.  ...:.|||..         ..:||.:..|...
Human   371 IRMEGEEA-LPAG--------SAAGPEQPQAGLLTPSTLLNLG---------GLTSSVLKTPITS 417

  Fly   273 IPLSSPKVAGKLTVKFGSLNSATAKTNNLSKVSSTSSPPSTYASGEVLS----PSTDNISNHKST 333
            :||             |.|.|:..|::......:..........|:..|    |:.:.....:..
Human   418 VPL-------------GPLASSPTKSSEGKDSGAAEGEKQEVGDGDCFSEKVEPAEEEAEEEEEE 469

  Fly   334 HCNQETEPPSSSSSEVEMKIGSMSTSPQTNDSDVPCSGFLQMQHMTTGGAY-------------- 384
            ...:|.|.......|.|...|.....|...|.::.     ...|...|.|.
Human   470 EEAEEEEEEEEEEEEEEEDEGCKGLFPSELDEELE-----DRPHEEPGAAAGSSSKKDLALSNQS 529

  Fly   385 -----------------TPQVSSFHASLAALAANESNDNRVKLITEFLQQQLQQHQSSLFPSPCP 432
                             |...||..||...:....:..||:...:|
Human   530 ISNSPLMPNVLQTLSRGTASTSSNSASSFVVFDGANRRNRLSFNSE------------------- 575

  Fly   433 DHPDLNGVDCKTCE---LLDIQQRSKS--------PSSS----------HHQFSQSLPQLQIQSQ 476
                  ||.....|   .||....|.:        |:.|          |||.:.||.:|.:
Human   576 ------GVRANVAEGGRRLDFADESANKDNATAPEPNESTEGDDGGFVPHHQHAGSLCELGV--- 631

  Fly   477 PQQTPHRSPCSNSVALPVSPSASSVASVGNASTATSSFTIGACSEHINGRPQGVDCARCEMLLNS 541
                   ..|         ||.|                             ||:|.:|:.:|.|
Human   632 -------GEC---------PSGS-----------------------------GVECPKCDTVLGS 651

  Fly   542 ARLNSG--VQMSTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGESACGYCLAGQQHPRLARG 604
            :|...|  ..|.:||||||||||:||||||||:|||.||:||||:...:|.||.:||.|||||||
Human   652 SRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKSGQPHPRLARG 716

  Fly   605 ESYSCGYKPYRCEICNYSTTTKGNLSIHMQSDKHLNNMQELNS-------SQNMVAAAAAAAVTG 662
            |||:|||||:|||:|||||||||||||||||||||||||.|.:       |....|||||||
Human   717 ESYTCGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNMQNLQNGGGEQVFSHTAGAAAAAAA--- 778

  Fly   663 KLLLSSSSPQVTAACPSNSGSGAGSGSSNIVGGTASLSGNATPSVTGANSSNANAGSNTNNAGTK 727
                       .||..:|..|..|:.|.                                   ||
Human   779 -----------AAAAAANISSSCGAPSP-----------------------------------TK 797

  Fly   728 P--KPSFRCDICSYDTSVARNLRIHMTSEKHTHNMAVLQNNIKHIQAFNFLQQQQQSGTGNIASH 790
            |  ||::||::|.|:|:||||||||||||||.|||.:||.|:..|      |..:..|.|:
Human   798 PKTKPTWRCEVCDYETNVARNLRIHMTSEKHMHNMMLLQQNMTQI------QHNRHLGLGS---- 852

  Fly   791 SSGSFMPEVALADLAYNQALMIQLLHQQQQHQQSANTKLSPSSSPVSTPDQFSFSPKPIKLNHG- 854
                 :|..|.|:| |...|        .|:....|.|:..::|..    ||..|  ..:|:..
Human   853 -----LPSPAEAEL-YQYYL--------AQNMNLPNLKMDSAASDA----QFMMS--GFQLDPAG 897

  Fly   855 -----TGAAMGIGMAMGMGMSHSNEVSCELSGDPHPLTKTDKWPMAFYSCLVCDCYSTNNLDDLN 914
                 |.|.:|..:.:.|.:.....||.||........:|:...:..:.|.||:.::|:|||.|.
Human   898 PMAAMTPALVGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLG 962

  Fly   915 QHLLLDRSRQSSSASSEIMVIHNNNYICRLCNYKTNLKANFQLHSKTDKHLQKLNFINHIREGGP 979
            .|:.::|    |.:..|...:..::|.|:||.|.|.||||||||.|||||:||...:.||:|||.
Human   963 LHMNVER----SLSEDEWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGK 1023

  Fly   980 QNEYKMQYQQQQLAANVVQLKCNCCDFHTNSIQKLSLHTQQMRHDTMRMIFQHLLYIVQQSEMHN 1044
            .||::::.   ....|.|.||||.||::|||::||.|||...||:....:::||    ||.|
Human  1024 ANEWRLKC---VAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHL----QQHE--- 1078

  Fly  1045 KSSGSAEDDPQCACPDEDQQLQLQSSKKLLLCQLCNFTAQNIHEMVQHVKGIRHLQVEQFICLQR 1109
                |..:...|                ...|.|||::.:....::|||:.::|.:.|....|||
Human  1079 ----SGVEGESC----------------YYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQR 1123

  Fly  1110 RSEN--QEIPALNEVFKV-----TEWVMENEDVSLAPGLNLARTTTNDATTDASYAAASSAA--- 1164
            ..:.  :|...|.::|.:     |:.....|||.   |.:.......:...|....|:||.|
Human  1124 LQKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVE---GPSETAADPEELAKDQEGGASSSQAEKE 1185

  Fly  1165 ---VPAIPDVSMFSPTSPSSCATSCDKNLSQIVLPNVNNLGSGVPTTVFKCNLCEYFVQSKSEIA 1226
               .||......|..:|.|..::...|...:|           .|..:::|..|:|.....:.:.
Human  1186 LTDSPATSKRISFPGSSESPLSSKRPKTAEEI-----------KPEQMYQCPYCKYSNADVNRLR 1239

  Fly  1227 AHIETEHSCAESDEFITIPTNTAALQAFQTAVAAAALAAVHQRCAVINPPTQDTVDEDKDLDTNV 1291
            .|..|:||                                      :.|.
Human  1240 VHAMTQHS--------------------------------------VQPM--------------- 1251

  Fly  1292 SDGPVGIKQERLEQEVDRTTSMDVTKDLASQATDFGAPESPKVAETEVGVQCPLCLENHFREKQY 1356
                                                             ::|||| ::....|.:
Human  1252 -------------------------------------------------LRCPLC-QDMLNNKIH 1266

  Fly  1357 LEDHLTSVHSVTRDGLSRLLLLVDQKALKKESTDI--ACPTDKAPYANTNALERAPTPIENTCNV 1419
            |:.|||.:|||..|.:.:|::.|....:...|:..  |...|:...:|.....:.|...|: ...
Human  1267 LQLHLTHLHSVAPDCVEKLIMTVTTPEMVMPSSMFLPAAVPDRDGNSNLEEAGKQPETSED-LGK 1330

  Fly  1420 SLIKSTSANPSQSVSLQGLSCQQCEASFKHEEQLLKHAQQNQHFSLQNGEYLCLAASHISRPCFM 1484
            :::.|.|...|..                     ||.:..:.....::..::|.     .:.|..
Human  1331 NILPSASTEQSGD---------------------LKPSPADPGSVREDSGFICW-----KKGCNQ 1369

  Fly  1485 TFRTIPTMISHFQDLHM---SLIISERHVYKYRCKQCSLAFKTQEKLTTHMLYHSMRDATKCSFC 1546
            .|:|...:.:||.::|.   .|.:|:||||||||.||||||||.|||..|..||.:|.||.|..|
Human  1370 VFKTSAALQTHFNEVHAKRPQLPVSDRHVYKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLC 1434

  Fly  1547 QRNFRSTQALQKHMEQAH-----------------------------AEDGT------------- 1569
            ||:||:.|||:||:|.:|                             |||.|
Human  1435 QRSFRTFQALKKHLETSHLELSEADIQQLYGGLLANGDLLAMGDPTLAEDHTIIVEEDKEEESDL 1499

  Fly  1570 -----------PSTRTNS-----------------------PQTPMLST----EETHKHLL---- 1592
                       .|.:.:|                       |..|...|    ..|.|::|
Human  1500 EDKQSPTGSDSGSVQEDSGSEPKRALPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHY 1564

  Fly  1593 ---AESHAVEREV-----------SGSDVSPIE-------------LETHL-------------- 1616
               :..|.::|.:           |..|..|.:             ||.|:
Human  1565 NSVSHLHKLKRALQESATGQPEPTSSPDNKPFKCNTCNVAYSQSSTLEIHMRSVLHQTKARAAKL 1629

  Fly  1617 -----------NKETRHLS---PTPMSLD------------------------------------ 1631
                       |..:..||   |:|:|..
Human  1630 EAASGSSNGTGNSSSISLSSSTPSPVSTSGSNTFTTSNPSSAGIAPSSNLLSQVPTESVGMPPLG 1694

  Fly  1632 -------------SQSHQKHLATFAALLKQQQCNSDAGGLHPEALSMSTGEMPPQLQGLQNLQ-- 1681
                         .::::|.||...|..:|||        ..:.......:...|.|.|...|
Human  1695 NPIGANIASPSEPKEANRKKLADMIASRQQQQ--------QQQQQQQQQQQQQQQAQTLAQAQAQ 1751

  Fly  1682 ---HIQQHFGAVAA-----------AAGLPINPVDMLNIMQFHHLM------SLNFM---NLAPP 1723
               |:||.....||           ....|:....:|.:.|..||:      |..|.   .::.|
Human  1752 VQAHLQQELQQQAALIQSQLFNPTLLPHFPMTTETLLQLQQQQHLLFPFYIPSAEFQLNPEVSLP 1816

  Fly  1724 LVFGANAAGNAVSG--------------------PSALNNSITTSTATSA--------------- 1753
            :..||........|                    |....|.::.:.:.||
Human  1817 VTSGALTLTGTGPGLLEDLKAQVQVPQQSHQQILPQQQQNQLSIAQSHSALLQPSQHPEKKNKLV 1881

  Fly  1754 ----------------SGLGDT----------------HLTSGVSSIP----------------- 1769
                            .|.|:|                .|..|..|.|
Human  1882 IKEKEKESQRERDSAEGGEGNTGPKETLPDALKAKEKKELAPGGGSEPSMLPPRIASDARGNATK 1946

  Fly  1770 ---------------------------VDSGK--------------------------------- 1774
                                       .|.|:
Human  1947 ALLENFGFELVIQYNENKQKVQKKNGKTDQGENLEKLECDSCGKLFSNILILKSHQEHVHQNYFP 2011

  Fly  1775 ---------------------------------------ATAVPPQ------------------- 1781
                                                   ..|.|||
Human  2012 FKQLERFAKQYRDHYDKLYPLRPQTPEPPPPPPPPPPPPLPAAPPQPASTPAIPASAPPITSPTI 2076

  Fly  1782 ---------TQLNA--------------------------------------------NANSQQL 1793
                     |||:.                                            ..|...|
Human  2077 APAQPSVPLTQLSMPMELPIFSPLMMQTMPLQTLPAQLPPQLGPVEPLPADLAQLYQHQLNPTLL 2141

  Fly  1794 ASNQKRARTRITDDQLKILRAHFDINNSPSEESIMEMSQKANLPMKVVKHWFRNTLFKERQRNKD 1858
            ....||.|||||||||::||.:||||||||||.|.||:.|:.||.||:|||||||||||||||||
Human  2142 QQQNKRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKERQRNKD 2206

  Fly  1859 SPYNFNNPPSTTLNLEEYERTGQAKVTPLNDTCSVAVTGPMTSSTISLPPSGNINLSSKENATSK 1923
            |||||:|||.|  :|||.:
Human  2207 SPYNFSNPPIT--SLEELK---------------------------------------------- 2223

  Fly  1924 VLAAGKANASGPVTFSATVPVSTPLSRPESTNSSGNISDYIGNNIFFGQLGSKEQILPYSLDGQI 1988
                                                                             
Human  2224 ----------------------------------------------------------------- 2223

  Fly  1989 KSEPQDDMIGATDFAYQTKQHSSFSFLKQQQDLVDPPEQCLTNQNADTAQDQSLLAGSSLASNCQ 2053
                                             :|
Human  2224 ---------------------------------ID------------------------------ 2225

  Fly  2054 SQQQINIFETKSESGSSDVLSRPPSPNSGAAGNVYGSMNDLLNQQLENMGSNMGPPKKMQIVGKT 2118
                                ||||||.                           |||:
Human  2226 --------------------SRPPSPE---------------------------PPKQ------- 2236

  Fly  2119 FEKNVAPMVTSGSVSTQFESNSSNSSSSSSSTSGGKRANRTRFTDYQIKVLQEFFENNSYPKDSD 2183
                                          ...|.||::||||||||::|||:||:.|:||||.:
Human  2237 ------------------------------EYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDE 2271

  Fly  2184 LEYLSKLLLLSPRVIVVWFQNARQKQRKIYENQPNNTLFENEE------TKKQNINYACKKCNLV 2242
            .|.||.||.|..|||||||||||||.||.||||......|..|      .:..|:||.||||:||
Human  2272 FEQLSNLLNLPTRVIVVWFQNARQKARKNYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLV 2336

  Fly  2243 FQRYYELIRHQKNHCFKEENNKKSAKAQIAAAQIAQNLSSEDSNSSMDIHHVGICPPGSAVASHT 2307
            |||.::||:|||..|:|:|:.:....:|           :|||..:|:     |..|.|:..|..
Human  2337 FQRIFDLIKHQKKLCYKDEDEEGQDDSQ-----------NEDSMDAME-----ILTPTSSSCSTP 2385

  Fly  2308 LSTPGSAAPLPGQYTQHSFGALPSPQHLFAKSSSLTDF---------------SPSTTPTPPQRE 2357
            :.:...:||.|......|...|    .|.|::..|..|               :||..|...|.:
Human  2386 MPSQAYSAPAPSANNTASSAFL----QLTAEAEELATFNSKTEAGDEKPKLAEAPSAQPNQTQEK 2446

  Fly  2358 RSN--------------------------SLDQIQRPP--------------------------- 2369
            :..                          ||..:.:||
Human  2447 QGQPKPELQQQEQPEQKTNTPQQKLPQLVSLPSLPQPPPQAPPPQCPLPQSSPSPSQLSHLPLKP 2511

  Fly  2370 -----------------KFDCDKCELNFNQLEKLREHQLLHLMNPGNICSDVGQNSNPE------ 2411
                             .:.||:|:|.|...|..:|||.||.::..|      |..:|:
Human  2512 LHTSTPQQLANLPPQLIPYQCDQCKLAFPSFEHWQEHQQLHFLSAQN------QFIHPQFLDRSL 2570

  Fly  2412 ----ANFGPFGSIL--QSLQQAAAQQQQQHHQQPPTK-------KRKY----------SDCSSNA 2453
                ..|.|...:|  |.|..|..|........|.|.       |||.          :|..:..
Human  2571 DMPFMLFDPSNPLLASQLLSGAIPQIPASSATSPSTPTSTMNTLKRKLEEKASASPGENDSGTGG 2635

  Fly  2454 DEMQSLSELEA--SQKKHEYLY-KYFMQNETSQEVKQQFLMQQQQKKLEQGNECDFELDFLTNFY 2515
            :|.|....|..  :.::.|.|| ||.:.:..::::......:...||.            :...:
Human  2636 EEPQRDKRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKR------------VVQVW 2688

  Fly  2516 QQNELKKVSNYDFLLQYYRTHEEAKSSQQHTFSSS---KKPTIEFLLQYYQLNESKKF-FQLVAS 2576
            .||...:.....|     |....|::.::..|..:   .|..:|..::....:|:|:. :.|..|
Human  2689 FQNTRARERKGQF-----RAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLS 2748

  Fly  2577 PQIIP---------DVPGYKPSLRIPKSTSDEAPYIGETSLEQATELQREKQDEQLRIDRPSEEN 2632
            ..::.         |:........:|.|:||          .|...|....:..:|     |...
Human  2749 AMLLDCDGGLQMKGDIFDGTSFSHLPPSSSD----------GQGVPLSPVSKTMEL-----SPRT 2798

  Fly  2633 DLSMNKNKVENI--------NNNNINVDQSNL-----TETNGGVPSVETKEECTQESSLIAMDDE 2684
            .||.:..|||.|        ::.|:|.||:.|     :..|..:....|.:|..      |.:|.
Human  2799 LLSPSSIKVEGIEDFESPSMSSVNLNFDQTKLDNDDCSSVNTAITDTTTGDEGN------ADNDS 2857

  Fly  2685 NKYLCTRSKQKD------DKEKSHYLHNLEDFLDATMIE----------NNSQTLTFNDDEKACQ 2733
            ...:.|.:|...      .|.....:...||.|.:.::.          :|..|:.:::......
Human  2858 ATGIATETKSSSAPNEGLTKAAMMAMSEYEDRLSSGLVSPAPSFYSKEYDNEGTVDYSETSSLAD 2922

  Fly  2734 KDELTQNSNAIEKRSSVSPVNVSSKQNKRLRTTILPEQLNFLYECYQSESNPSRKMLEEISKKVN 2798
            ....:..::....:|..|.   .....||.||.:...||..|..|:.....|:....|.:...:.
Human  2923 PCSPSPGASGSAGKSGDSG---DRPGQKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIG 2984

  Fly  2799 LKKRVVQVWFQNSRAKDKKSR--NQRHYAHISDDNSYDGSSGKEVYSDLRSNGITVDTDLETNLQ 2861
            |.||||||||||:|||:|||:  ..:|:.  .:..||:|..                       .
Human  2985 LPKRVVQVWFQNARAKEKKSKLSMAKHFG--INQTSYEGPK-----------------------T 3024

  Fly  2862 DCQLCQV---TQVNIRKHAFSVEHISKMKKLLEQTTELYAQSNGSGSEDNDSDREKRFYNLSKAF 2923
            :|.||.:   .::::|.|.||.:||||:|..:             ||:   .|:||.:::.:...
Human  3025 ECTLCGIKYSARLSVRDHIFSQQHISKVKDTI-------------GSQ---LDKEKEYFDPATVR 3073

  Fly  2924 LLQHVVTNATSHAIHTARQDSDVIAEGNCIL 2954
            .|.             |:|:.|.|.:.|.:|
Human  3074 QLM-------------AQQELDRIKKANEVL 3091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zfh2	NP_524623.2	C2H2 Zn finger	561..581	CDD:275368	15/19 (79%)
		C2H2 Zn finger	616..633	CDD:275368	15/16 (94%)
		C2H2 Zn finger	1515..1542	CDD:275371	17/26 (65%)
		C2H2 Zn finger	1543..1564	CDD:275371	12/20 (60%)
		Homeodomain	1798..1857	CDD:459649	45/58 (78%)
		Homeodomain	2155..2211	CDD:459649	38/55 (69%)
		Homeodomain	2761..2817	CDD:459649	24/55 (44%)
ZFHX3	XP_054236368.1	C2H2 Zn finger	673..693	CDD:275368	15/19 (79%)
		C2H2 Zn finger	728..745	CDD:275368	15/16 (94%)
		C2H2 Zn finger	1362..1385	CDD:275368	6/27 (22%)
		C2H2 Zn finger	1403..1423	CDD:275371	13/19 (68%)
		C2H2 Zn finger	1431..1452	CDD:275371	12/20 (60%)
		C2H2 Zn finger	1547..1571	CDD:275368	4/23 (17%)
		C2H2 Zn finger	1598..1616	CDD:275368	3/17 (18%)
		HOX	2145..2201	CDD:197696	41/55 (75%)
		Homeodomain	2243..2299	CDD:459649	38/55 (69%)
		COG5576	2594..2738	CDD:227863	25/160 (16%)
		Homeodomain	2642..2698	CDD:459649	10/67 (15%)
		Homeodomain	2947..3003	CDD:459649	24/55 (44%)
		Herpes_BLLF1	<3104..>3191	CDD:282904