DRSC/TRiP Functional Genomics Resources

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Protein Alignment zfh2 and unc-4

DIOPT Version :10

Sequence 1:NP_524623.2 Gene:zfh2 / 43795 FlyBaseID:FBgn0004607 Length:3005 Species:Drosophila melanogaster
Sequence 2:NP_573242.2 Gene:unc-4 / 32757 FlyBaseID:FBgn0024184 Length:588 Species:Drosophila melanogaster


Alignment Length:648 Identity:122/648 - (18%)
Similarity:194/648 - (29%) Gaps:234/648 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1565 AEDGTPSTRTNSPQTPMLSTEETHKHLLAESHAVEREVSGSDVSPIELETHLNKETRHLSPTPMS 1629
            :|..|....||:..:.......:|.:            :.::.||.|:.    :||...|.|..:
  Fly     6 SEGDTKKFLTNNNNSSASRNNNSHNN------------NNNNHSPKEIP----EETGRSSSTSSN 54

  Fly  1630 LDSQSHQ----KHL----ATFAALLKQQQCNSDAGGLHPEALSMSTGEMPPQLQGLQNLQHIQQH 1686
            ....:|:    :||    .:.|.......|...:.||||.|             .||        
  Fly    55 SIPNAHRTNAGQHLLGGSPSSACSTSVSGCGMPSEGLHPTA-------------ALQ-------- 98

  Fly  1687 FGAVAAAAGL--------PINPVDMLNIMQFHHLMSLNFMNLAPPLVFGAN-------------- 1729
              ..||||.|        |..|                |:....|.|||.|              
  Fly    99 --LYAAAAQLAPNGVRVPPWGP----------------FLQFGVPGVFGPNGPFLGRPRFDAASA 145

  Fly  1730 -------AAGNAVSGPSALN--NSITTSTATSASGLGDTHLTSGVSSIPVDSGKAT--------- 1776
                   ||..|.:..:|:|  |:....|..||:.|.:.......:...|.|..||         
  Fly   146 GGHPNSAAAAAAATQMAAVNASNAFANLTGLSAAALRNVSAAQTTAVAAVASTVATIQHRLMIGN 210

  Fly  1777 ------AVPPQTQLN------ANANSQQLASNQKRARTRITDDQLKILRAHFDINNSPSEESIME 1829
                  |.||....|      .:.:....|:.::|:||.....||:.|...|..::.|.......
  Fly   211 RQSLPPAGPPSEGSNEDGGFPGDGDDDSSAAKRRRSRTNFNSWQLEELERAFSASHYPDIFMREA 275

  Fly  1830 MSQKANLPMKVVKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYERTGQAKVTPLNDTCSVA 1894
            ::.:.:|....|..||:|...|.|:|                   |:.:.|..:  |.::     
  Fly   276 LAMRLDLKESRVAVWFQNRRAKVRKR-------------------EHTKKGPGR--PAHN----- 314

  Fly  1895 VTGPMTSSTISLPPSGNINLSSKENA-TSKVLA------AGKANASGPVTFSATVPVSTPLSRPE 1952
             ..|.|.|...:||:   .|.:||.| ..|.||      |.|..|.|       :.|.....:.|
  Fly   315 -AQPQTCSGEPIPPN---ELKAKERARRRKKLAKAIDRQARKLQAKG-------ITVDLEALKAE 368

  Fly  1953 STNSSGNISDYIGNNIFFGQLGSKEQILPYSLDGQIKSEP-QDDMIGATDFAYQTKQHSSFSFLK 2016
                  .||.:..|..|              .|..::.:. |.|::|.||           |..:
  Fly   369 ------YISQHKANGTF--------------SDSDLEDDGIQIDVVGGTD-----------SDDE 402

  Fly  2017 QQQDLVDPPE-----------------------QCLTNQNADTAQDQSLLAGSSLASNCQSQQQI 2058
            ...|.|.|..                       .|..:.:.|:::..|.:.|.            
  Fly   403 GDSDAVSPVRLGGGGGGGGGTGGGGGGGASSSLHCGLDGDGDSSRAGSFIGGG------------ 455

  Fly  2059 NIFETKSESGSSDVLSRPPSPNSGAAGNVYGSMNDLLNQQLENMGSNMGPPKKMQIVGKTFEK 2121
                  ...||...::.|...::||.  .:|.:..:...:.|........||.:....|.|.:
  Fly   456 ------GSLGSPSSVAPPSMLSNGAV--QFGKLEPMDGNESEERDRERDSPKPLLFPAKAFHQ 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zfh2NP_524623.2 C2H2 Zn finger 561..581 CDD:275368
C2H2 Zn finger 616..633 CDD:275368
C2H2 Zn finger 1515..1542 CDD:275371
C2H2 Zn finger 1543..1564 CDD:275371
Homeodomain 1798..1857 CDD:459649 16/58 (28%)
Homeodomain 2155..2211 CDD:459649
Homeodomain 2761..2817 CDD:459649
unc-4NP_573242.2 Homeodomain 244..300 CDD:459649 14/55 (25%)
Blue background indicates that the domain is not in the aligned region.

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