Protein Alignment zfh2 and Zfhx2

DIOPT Version :10

• Sequence 1: NP_524623.2
• Gene: zfh2 / 43795
• FlyBaseID: FBgn0004607
• Length: 3005
• Species: Drosophila melanogaster
• Sequence 2: XP_011243362.3
• Gene: Zfhx2 / 239102
• MGIID: 2686934
• Length: 2572
• Species: Mus musculus
• Alignment Length: 3122
• Identity: 645/3122 - (20%)
• Similarity: 986/3122 - (31%)
• Gaps: 1241/3122 - (39%)

  Fly    17 LDGSAHIIATDNTNGGGSGSGQNCY---------GSTTNSLKNLSKDKGRGQEEKDI-------- 64
            ||.|:|:.         ..:|...|         ||..:..|....|:...:||..:
Mouse   101 LDLSSHLF---------FAAGGQAYLLANLPLPRGSELSLPKGFPWDEASAKEEPSLPLLTHFPS 156

  Fly    65 EHPSQYHREQSDNKRQ-----EEAVDNRPGVESLGSACYKSSPKIHSFRVV--SAQD-----ANS 117
            .|.:..|.:...:..|     ::.:.:.....|| :||.:......|:::|  ..:|     ..|
Mouse   157 SHLTTLHIQHGFDPIQGFSSSDQMLSHDTSAPSL-AACERRDGSFWSYQLVPNPTEDPKDGPLGS 220

  Fly   118 TCQDQIRAFKIQKPILMCFICKLSFGNVKSFSLHANTEHRLNLEELDQQ-LLNREYSSAIIQRNM 181
            ..:|....|.|      |.:|:|.||.:::|..| ...|.:.|.....| ||.   |.|::|...
Mouse   221 RREDHRAMFWI------CLLCRLGFGRLQTFIGH-TLSHGVKLSPAHHQGLLG---SPAVLQEGH 275

  Fly   182 D-EKPQISFLQPLANNDASADTNDTEKLQTATEGSDATLPSSPQPVFRNVSELEPENKQETEQNR 245
            | ....:|||:|......|.:..||..:...|.|:.|
Mouse   276 DGGMALLSFLEPKFLTRPSPEVPDTSTVTVKTNGAQA---------------------------- 312

  Fly   246 LLNQDREQEPESDQHTSSSKMAAPS-AYIPLSSPKVAGKLTVKFGSLNSATAKTNNLSKVSSTSS 309
                 .:..||:|    ...:..|: ..|.||.|                              |
Mouse   313 -----EDGPPEAD----GQALVLPAEEVIALSPP------------------------------S 338

  Fly   310 PPSTYASGEVLSPSTDNISNHKSTHCNQETEPPSSSSSEVEMKIGSMSTSPQTNDSDVPCSGFLQ 374
            ||:..|                       |..||.:               |..||.||
Mouse   339 PPTALA-----------------------TWDPSPT---------------QAKDSPVP------ 359

  Fly   375 MQHMTTGGAYTPQVSSFHASLAALAANESNDNRVKLITEFLQQQLQQHQSSLFPSPCPDHPDLNG 439
                                                            :....|...|:..:.:|
Mouse   360 ------------------------------------------------RGEAGPDWFPEGQEEDG 376

  Fly   440 VDCKTCELLDIQQRSKSPSSSHHQFSQSLPQLQIQSQPQQTPHRSPCSNSVALPVSPSAS----- 499
            ..|                         ||..|          .||.|..||:..:|:.|
Mouse   377 GLC-------------------------LPLNQ----------SSPTSKEVAVLPAPAGSPEDTS 406

  Fly   500 ----SVASVGNASTATSSFTIGACSEHINGRPQGVDCARCEMLLNSARLNSGVQMSTRNSCKTLK 560
                |.....:.:.|.::|             ||:..:....||:|           ||||||||
Mouse   407 DPPPSCRLADDYTPAPAAF-------------QGLSLSSHMSLLHS-----------RNSCKTLK 447

  Fly   561 CPQCNWHYKYQETLEIHMREKHPDGESACGYCLAGQQHPRLARGESYSCGYKPYRCEICNYSTTT 625
            ||:||||||||:||::|||||||:..|.|.||.||..||||||||||:||||||||::|||||||
Mouse   448 CPKCNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNCGYKPYRCDVCNYSTTT 512

  Fly   626 KGNLSIHMQSDKHLNNMQELNSSQNMVAAAAAAAVTGKLLLSSSSPQVTAACPSNSGSGAGSGSS 690
            ||||||||||||||.|:|                                      |..||.|
Mouse   513 KGNLSIHMQSDKHLANLQ--------------------------------------GFQAGPG-- 537

  Fly   691 NIVGGTASLSGNATPSVTGANSSNANAGSNTNNAGTKPKPSFRCDICSYDTSVARNLRIHMTSEK 755
                      |.|:|  ..|:....:.|...    .|.|.|::|.:|||:|:::|||||||||||
Mouse   538 ----------GQASP--PEASLPPTSVGDKE----PKTKSSWQCKVCSYETNISRNLRIHMTSEK 586

  Fly   756 HTHNMAVLQNNI----------------------KHIQAFNFLQQQQQSGTGNIASHSSGSFMPE 798
            |..|:.:|...:                      ...:.|.:...|        |.....:.||.
Mouse   587 HMQNVLMLHQGLPLGLPPGLVGPGPPPPPGAAPTNPPELFQYFGPQ--------ALGQPQTPMPG 643

  Fly   799 VALADLAYNQALMIQLLHQQQQHQQSANTKLSPSSSPVSTPDQFSFSPKPIKLNHGTGAAMGIGM 863
            ..|..   ::.|..||| ....|...|..:..|:::|.|...:....|..:
Mouse   644 PGLRP---DKPLEAQLL-LNGFHHLGAPARKFPTAAPGSLSPETHLPPSQL-------------- 690

  Fly   864 AMGMGMSHSNEVSCELSGDPHPLTKTDKWPMAFYSCLVCDCYSTNNLDDLNQHLLLDRSRQSSSA 928
               :| |.|:.:....|.|..|..|.       :.||||..:||::|:.|..|..:.|    |..
Mouse   691 ---LG-SSSDGLPTSPSPDDSPALKV-------FRCLVCQAFSTDSLELLLYHCSIGR----SLP 740

  Fly   929 SSEIMVIHNNNYICRLCNYKTNLKANFQLHSKTDKHLQKLNFINHIREGG-----PQNEYKMQYQ 988
            .:|...:..:.:.|:||.|.|.||||||||.|||||.||.....|:||||     |
Mouse   741 EAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHTQKYQLAAHLREGGGAMGTP--------- 796

  Fly   989 QQQLAA----------NVVQLKCNCCDFHTNSIQKLSLHTQQMRHDTMRMIFQHLLYIVQQSEMH 1043
              .|.|          :.:.|:||.|||.:||.:|:.|||:...|:....|::.||      ||.
Mouse   797 --SLLALGDGASYGSISPLHLRCNICDFESNSKEKMQLHTRGSAHEENSQIYKFLL------EME 853

  Fly  1044 NKSSGSAEDDPQCACPDEDQQLQLQSSKKLLLCQLCNFTAQNIHEMVQHVKGIRHLQVEQFICLQ 1108
            ...:|          |:..          |..|.||.:...:...::||::...|...:    .|
Mouse   854 GAEAG----------PEPG----------LYHCLLCAWDTPSRLALLQHLRTPAHRDAQ----AQ 894

  Fly  1109 RRSENQEIPALNEVFKVTEWVMENEDVSLAPGLNLARTTTNDATTDASYAAASSAAVPAIPDVSM 1173
            ||.:                :::|                         ..|:...:.|:..:..
Mouse   895 RRLQ----------------LLQN-------------------------GPAAEEGLSALQSILS 918

  Fly  1174 FSPTSPSSCATSCDKNLSQIVLPNVNNLGSGVPTTVFKCNLCEYFVQSKSEIAAHIETEHSCAES 1238
            ||.....:...:.|..|:|             |.|              ||..|..:||...:|.
Mouse   919 FSHGRLQTPGKASDTPLAQ-------------PPT--------------SEKDAQNKTEQQASEV 956

  Fly  1239 DEFITIPTNTAALQ-AFQTAVAAAALAAVHQRCAVINPPTQDTVDEDKDLDTNVSDGPVGIKQER 1302
            .|..:.|...:|.| ..:|.|...........|:.::|
Mouse   957 TEDRSGPPRDSANQITVRTGVTGMMKVFCCPYCSFLSP--------------------------- 994

  Fly  1303 LEQEVDRTTSMDVTKDLASQATDFGAPESPKVAETEVGVQCPLCLEN-------HFREKQYLEDH 1360
               |.|:..    ...|:..|.      .||       .:||||.|.       ||        |
Mouse   995 ---ECDQVR----VHTLSQHAV------QPK-------YRCPLCQEQLVGRPALHF--------H 1031

  Fly  1361 LTSVHSVTRDGLSRLLLL------------------------VDQKALKKEST----DIACPTDK 1397
            |:.:|:|..:.:.:|||:                        :|..|...|.|    .:|..::.
Mouse  1032 LSHLHNVVPECVEKLLLVATTVEMTFATKMLPGPTLNPVEDGLDHPAPGAEPTPNRDQVAESSNL 1096

  Fly  1398 APYANTN-ALERAPTPIENTCNVSLIKSTSANPSQSVSLQGLSCQQCEASFKHEEQLLKHAQQNQ 1461
            ||..:.: .||....|:|.:      :..|.:|.|..|.......:.:|..   |:|......::
Mouse  1097 APEVSPDPPLEPPLAPVEGS------REPSESPDQPPSPAPSPAPRLDAQV---EELAPLPTMSE 1152

  Fly  1462 HFSLQNGEYLCLAASHISRPCFMTFR-TIPTMISHFQDLHMSLIISERHVYKYRCKQCSLAFKTQ 1525
            ......||......:.......:|:| |....:..|.|          ....|:|..|..:|..:
Mouse  1153 EEEGAMGEPRSAEPTPADSRHPLTYRKTTNFALDKFLD----------PARPYKCTVCKESFTQK 1207

  Fly  1526 EKLTTHMLY------HSMRDAT-------------------------KCSFCQRNFRSTQALQKH 1559
            ..|..|  |      |.|:.|.                         ||:.|:.::..:..|:.|
Mouse  1208 NILLVH--YNSVSHLHKMKKAAIDPSGPARGEAGIPPPAATASDKPFKCTVCRVSYNQSSTLEIH 1270

  Fly  1560 MEQAHAEDGTPSTRTNSPQTPMLSTEETHKHLLAESHAVEREVSGSD----VSPIELETHLNKET 1620
            |.....:..:...:.::........:|..|....|..| ..|..|.|    :|.:..
Mouse  1271 MRSVLHQTRSRGAKIDARAEGAERGQEEFKEGETEGEA-GTEKKGPDPGGFMSGLPF-------- 1326

  Fly  1621 RHLSPTPMSLDSQSHQKHLATFAALLKQQQCNSDAGGLHPEALSMSTGEMPPQLQGLQNLQHIQQ 1685
              |||.|..||       |..|:|.|           ..|..|       ||
Mouse  1327 --LSPPPPPLD-------LHRFSAPL-----------FTPPVL-------PP------------- 1351

  Fly  1686 HFGAVAAAAGLPINPVDMLNIMQFHHLMS--LNFMNLAPPLVFGANAAGNAVSGPSALNNSITTS 1748
                      .|:.|..:|.:.|...|:.  |:.:.:.|.|         |::.|:.:
Mouse  1352 ----------FPLVPESLLKLQQQQLLLPFYLHDLKVGPKL---------ALASPTPM------- 1390

  Fly  1749 TATSASGLGDTHLTSGVSSIPVDSGKATAVPPQTQLNANANSQQLASNQKRARTRITDDQLKILR 1813
                             .|:|..:......||:.:|          :.|:..|.         |.
Mouse  1391 -----------------LSLPAANPPPLPAPPKAEL----------AEQEWERP---------LM 1419

  Fly  1814 AHFDINNSPSEESIMEMSQKANLPMKVVKHWFRNTLFKERQRNKDS-PYNFNNPPSTTLNLEEYE 1877
            |.......||..:....::.|....|.:...|...|..:....|.: |     ||.|.
Mouse  1420 AEEGTEAGPSSPTHTSPNEAARTAAKALLENFGFELVIQYNEGKQAVP-----PPPTP------- 1472

  Fly  1878 RTGQAKVTPLNDTCSVAVTGPMTSSTISLPPSGNINLSSKENATSKVLAAGKANASGPVTFSATV 1942
                                         ||..::....|       ||.|..
Mouse  1473 -----------------------------PPPESLGGGDK-------LACGAC------------ 1489

  Fly  1943 PVSTPLSRPESTNSSGNISDYIGNNIFFGQLGSKEQILPYSLDGQIKSEPQDDMIGATDFAYQTK 2007
                                        |:|.|...||          :..::.:......::..
Mouse  1490 ----------------------------GKLFSNMLIL----------KTHEEHVHRRFLPFEAL 1516

  Fly  2008 QHSSFSFLKQQQDLVDPPEQCLTNQNADTAQDQSLLAGSSLASNCQSQQQINIFETKSESGSSDV 2072
            ...:..|.|....|..||.:
Mouse  1517 SRYAAQFRKSYDSLYPPPVE--------------------------------------------- 1536

  Fly  2073 LSRPPSPNSGAAGNVYGSMNDLLNQQLENMGSNMGPPKKMQIVGKTFEKNVAPMVTSGSVSTQFE 2137
               ||.|..|.               ||:      ||:    :|..|   |.|....|.:.|..|
Mouse  1537 ---PPKPPDGC---------------LES------PPQ----LGPPF---VVPEPEVGGIHTSEE 1570

  Fly  2138 SNSSNS----SSSSSSTSG--------GKRANRTRFTDYQIKVLQEFFENNSYPKDSDLEYLSKL 2190
            .:.|..    |.....:.|        |:|.:||:||::|.:.||.|||.::||||.::|.|:.|
Mouse  1571 RSLSGGGPWPSEEEEGSRGSLPPAVPVGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASL 1635

  Fly  2191 LLLSPRVIVVWFQNARQKQRK-IYENQPNNTLFENEETKKQNINYACKKCNLVFQRYYELIRHQK 2254
            |.|:.||:||||||||||.|| ..|..|......:....      .|::|:..|...:||:||.|
Mouse  1636 LGLASRVVVVWFQNARQKARKNACEGGPVTAGGASGGAS------GCRRCHATFACVFELVRHLK 1694

  Fly  2255 NHCFKEENNKKSAKAQIAAAQIAQNLSSEDSNSSMDIHHVGICPPGSAVASHTLSTPGSAAPLPG 2319
            . |:.::..::..:|:  ..:..:.:..|:                   |......|.:|.|
Mouse  1695 K-CYDDQPPEEEEEAE--RGEEEEEVEEEE-------------------AEERNLEPAAARP--- 1734

  Fly  2320 QYTQHSFGALPSPQHLFAKSSSLTDFSPSTTPTPPQRERSNSLDQIQRPPKFDCDKCELNFNQLE 2384
                   |. |||:|...:..|.|:      ||.|:.:.|.. .....||.:.||:|..:|...:
Mouse  1735 -------GG-PSPEHADGEDLSQTE------PTRPESKESEG-KAPPSPPVYACDQCAASFPSQD 1784

  Fly  2385 KLREHQLLHLMNPGNICSDVGQNSNPEAN--------FGPFGSILQSLQQAAAQQQQQHHQQPPT 2441
            .|..|..|||:      ..|..::.|.:.        ||....::........          ..
Mouse  1785 LLTTHHRLHLL------PSVQPSAPPPSQLLDLPLLVFGERNPVVSGTSSVTG----------TP 1833

  Fly  2442 KKRKYSD--CSSNADEMQSLSELEASQKKH----------EYLYKYFMQNETSQEVKQQFLMQQQ 2494
            .|||:.|  .|....|.....|.|..:.|.          |.||:::||:            ...
Mouse  1834 LKRKHDDGSLSPTGSEAGGGGEGEPPKDKRLRTTILPEQLEILYRWYMQD------------SNP 1886

  Fly  2495 QKKLEQGNECDFELDFLTNFYQQNELKKVSNYDFLLQYYRTHEEAKSSQQHTFSSSKKPTIEFLL 2559
            .:|:         ||.::                        ||.         ..||..::...
Mouse  1887 TRKM---------LDCIS------------------------EEV---------GLKKRVVQVWF 1909

  Fly  2560 QYYQLNESKKFFQL----VASPQIIPDVPGYKPSLRIPKSTSDEAPYIGETSLEQATELQREKQD 2620
            |..:..|.|..|:.    ||.|.:.|.||   ||         .||:.....|  .::::.|...
Mouse  1910 QNTRARERKGQFRSTPGGVAGPAVKPTVP---PS---------PAPFPKFNLL--LSKIEDETGK 1960

  Fly  2621 EQLRIDRPSEENDLSMNKNKVENINNNNINVDQSNLTETNGGVP--------SVETKEECTQESS 2677
            |..:.|.|:                     .....:|...|.:|        :|.|.|.......
Mouse  1961 EAPKRDAPA---------------------FPYPTVTPAVGPLPFLPPGKEAAVPTPEPPPPLPP 2004

  Fly  2678 LIAMDDENKYLCTRSKQKDDKEKSHYLHNLEDFLDATMIENNSQTLTFNDDEKACQKD--ELTQN 2740
            ....:||.         .::..|:                        :.:.:||...  :|:.:
Mouse  2005 PALSEDEG---------PEEPSKA------------------------SPESEACSPSAGDLSDS 2036

  Fly  2741 S-NAIEKRSSVSPVNVS-----------SKQNKRLRTTILPEQLNFLYECYQSESNPSRKMLEEI 2793
            | :::.:..|......|           |...:|.||.:...||..:..||::...|:.:..|.:
Mouse  2037 SASSLAEPESPGAGGTSGGPGGGTGVPDSMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVL 2101

  Fly  2794 SKKVNLKKRVVQVWFQNSRAKDKKSRNQRHYAHISDDNSYDGSSGKEVYSDLRSNGITVDTDLET 2858
            .:::.|.|||:||||||:|||:||::.|        ..:..||.|.       |.|.:.     .
Mouse  2102 GEEIGLPKRVIQVWFQNARAKEKKAKLQ--------GTAPPGSGGS-------SEGTSA-----A 2146

  Fly  2859 NLQDCQLCQVT---QVNIRKHAFSVEHISKMKKLLEQTTELYAQSNGSGSEDNDSDREKRFYNLS 2920
            ...||..|.|.   .|:.|.|.||.:|::|:|:.:.      ||...          |.:.|:|:
Mouse  2147 QRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVR------AQLKS----------ESKCYDLA 2195

  Fly  2921 KA 2922
            .|
Mouse  2196 PA 2197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zfh2	NP_524623.2	C2H2 Zn finger	561..581	CDD:275368	15/19 (79%)
		C2H2 Zn finger	616..633	CDD:275368	14/16 (88%)
		C2H2 Zn finger	1515..1542	CDD:275371	9/57 (16%)
		C2H2 Zn finger	1543..1564	CDD:275371	5/20 (25%)
		Homeodomain	1798..1857	CDD:459649	9/58 (16%)
		Homeodomain	2155..2211	CDD:459649	32/55 (58%)
		Homeodomain	2761..2817	CDD:459649	22/55 (40%)
Zfhx2	XP_011243362.3	C2H2 Zn finger	448..468	CDD:275368	15/19 (79%)
		zf-H2C2_5	501..525	CDD:404746	21/23 (91%)
		C2H2 Zn finger	503..520	CDD:275368	14/16 (88%)
		C2H2 Zn finger	1197..1219	CDD:275368	6/23 (26%)
		C2H2 Zn finger	1254..1272	CDD:275368	4/17 (24%)
		Homeodomain	1599..1656	CDD:459649	32/56 (57%)
		PHA03247	<1757..2030	CDD:223021	67/411 (16%)
		COG5576	<1828..1954	CDD:227863	36/203 (18%)
		Homeodomain	1862..1918	CDD:459649	15/109 (14%)
		Homeodomain	2069..2125	CDD:459649	22/55 (40%)
		PHA03247	<2196..2310	CDD:223021	1/2 (50%)
		C2H2 Zn finger	2453..2496	CDD:275371
		C2H2 Zn finger	2497..2519	CDD:275371