Protein Alignment Asator and VRK2

DIOPT Version :10

• Sequence 1: NP_651924.2
• Gene: Asator / 43794
• FlyBaseID: FBgn0039908
• Length: 1349
• Species: Drosophila melanogaster
• Sequence 2: NP_006287.2
• Gene: VRK2 / 7444
• HGNCID: 12719
• Length: 508
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 126/494 - (25%)
• Similarity: 209/494 - (42%)
• Gaps: 114/494 - (23%)

  Fly   172 RWKVVRKIGGGGFGEIYEGQDLITREQVA---LKVESARQPK--QVLKMEVAVLKKLQGKEHVCR 231
            :|.:.:|||.||||.||........|:.|   :|||......  ..||....|.||...|:.:.|
Human    28 QWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIER 92

  Fly   232 ----------FIGCG----RNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTLRLGLQILKAIE 282
                      |.|.|    :...:.::||:..|.:|.::  :...|.|..||.|:||:::|..:|
Human    93 KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFKKSTVLQLGIRMLDVLE 155

  Fly   283 SIHSVGFLHRDIKPSNFSVGRLPY-NCRRVYMLDFGLARQYTTGTGEVRCPRA---------AAG 337
            .||...::|.|||.:|..:|   | |..:||:.|:||:.:|        ||..         ..|
Human   156 YIHENEYVHGDIKAANLLLG---YKNPDQVYLADYGLSYRY--------CPNGNHKQYQENPRKG 209

  Fly   338 FRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVNGQLPW-RKIKDKEQVGLTKEKYDHRI--- 398
            ..||:.:.|::||:...:.|..|:..|.|.::.::.|:||| :.:||...|...|......:
Human   210 HNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQS 274

  Fly   399 LLKHLPS-----DLKQFLEHIQSLTYGDRPDYAML----------IGLFERCMKRRGVKESDPYD 448
            :||..||     ::.|||....||.|.::|:|..|          :|..:...|.:.:....| :
Human   275 VLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTP-N 338

  Fly   449 WEKVDS--TAIGNISATGNPSIPIKSDYMHGNITQMTVAA-------------SNASGTEYIRKR 498
            .:||||  .|...::...|..|..|   :|...:..:.|.             :|.:..|..|:|
Human   339 SQKVDSQKAATKQVNKAHNRLIEKK---VHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRR 400

  Fly   499 AEIETAHITATDPLNIKEKVDKNCNATSLAQPAKGSGEPMVQHGNAANNQNITSKGLQQQS---- 559
            .:.:.:.    :|||   :|:......|..|......||         :|:.||..:.::|
Human   401 QKYQESQ----EPLN---EVNSFPQKISYTQFPNSFYEP---------HQDFTSPDIFKKSRSPS 449

  Fly   560 ----TLTNSQVAIANIQSA----PSMIEREDVQYTKLEE 590
                |.|.| ..|.:::|:    |::     .|:|..||
Human   450 WYKYTSTVS-TGITDLESSTGLWPTI-----SQFTLSEE 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asator	NP_651924.2	STKc_TTBK	172..433	CDD:270919	88/308 (29%)
VRK2	NP_006287.2	STKc_VRK2	16..314	CDD:271025	87/298 (29%)
		Interaction with MAP3K7. /evidence=ECO:0000269|PubMed:17709393	397..508		24/108 (22%)