Protein Alignment Asator and Vrk2

DIOPT Version :10

• Sequence 1: NP_651924.2
• Gene: Asator / 43794
• FlyBaseID: FBgn0039908
• Length: 1349
• Species: Drosophila melanogaster
• Sequence 2: NP_081536.2
• Gene: Vrk2 / 69922
• MGIID: 1917172
• Length: 503
• Species: Mus musculus
• Alignment Length: 493
• Identity: 111/493 - (22%)
• Similarity: 187/493 - (37%)
• Gaps: 146/493 - (29%)

  Fly   150 KAKESVKMTSEDLLQPGHVVKE----RWKVVRKIGGGGFGEIYEGQDLITREQVALKVESA-RQP 209
            :.||..|:...  |..|.::.:    ||.:.:.||.||||.||          :|...... :..
Mouse     4 RRKEKYKLPVP--LPEGKILDDMEGNRWALGKMIGSGGFGLIY----------LAFPTNKPNKDA 56

  Fly   210 KQVLKMEV--------------------AVLKKLQGKE----HVCRFIGCGRND----RFNYVVM 246
            :.|:|:|.                    .:.|.:|.::    .:..|.|.|..|    .:.::||
Mouse    57 RHVIKLEYQENGPLFSELKFYQRAAKRECIQKWIQQRKLDYLGIPVFYGFGLTDFKGRSYRFMVM 121

  Fly   247 QLQGKNLAELRRAQPRGAFSLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRV 311
            :..|.:|.:|  ....|.|...|.|:||:::|..:|.||...::|.|||.:|..:...  |..||
Mouse   122 ERLGIDLQKL--LDQNGGFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLDFT--NPDRV 182

  Fly   312 YMLDFGLARQYTTGTGEVRCPRA---------AAGFRGTVRYASINAHRNREMGRHDDLWSLFYM 367
            |:.|:||:.:|        ||..         ..|..||:.:.|::||:.....|..|:..|.|.
Mouse   183 YLADYGLSYRY--------CPNGNHKQYQEDPRKGHNGTIEFTSLDAHKGVAPSRRSDVEILGYC 239

  Fly   368 LVEFVNGQLPWR-KIKDKEQVGLTKEKYDHRILLKHLP-------------SDLKQFLEHIQSLT 418
            ::.::.|:|||. |:.|...|...|..     ||..||             |:|.::|.::.:|.
Mouse   240 MLHWLFGKLPWEAKLDDPVAVQTAKTN-----LLDELPESVLKWAPSGSSCSELVKYLMYVHNLA 299

  Fly   419 YGDRPDYAML----------IGLFERCMKRRGVKESDPYDWEKVDSTAIGNISATGNPSIPIKSD 473
            |.|:|||..|          :|..|...|.:.|....|.. :||||.     .||..|:
Mouse   300 YDDKPDYQKLKKILNPDGVPLGPLEFSTKVQSVHVRTPAQ-QKVDSP-----KATRKPA------ 352

  Fly   474 YMHGNITQMTVAASNASGTEYIRKRAEIETAHITATDPLNIKEKVDKNCNATSLAQPAKGSGEPM 538
                              .|:                |....:||.:...|..  :..:...:|.
Mouse   353 ------------------NEF----------------PAKFPKKVHRETRARQ--REEQEDSQPT 381

  Fly   539 VQHGNAANNQNITSKGLQQQSTLTNSQVAIANIQSAPS 576
            :.....|..:|..::.:.:.|.:.:.   :.::|..||
Mouse   382 MLQSRPAAPENSRTRKIHEYSDIFSE---MQSLQQTPS 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asator	NP_651924.2	STKc_TTBK	172..433	CDD:270919	83/322 (26%)
Vrk2	NP_081536.2	Protein Kinases, catalytic domain	16..314	CDD:473864	83/324 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	334..353		8/48 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..395		6/34 (18%)
		Interaction with MAP3K7. /evidence=ECO:0000250|UniProtKB:Q86Y07	392..503		5/28 (18%)