Protein Alignment Asator and vrk-1

DIOPT Version :10

• Sequence 1: NP_651924.2
• Gene: Asator / 43794
• FlyBaseID: FBgn0039908
• Length: 1349
• Species: Drosophila melanogaster
• Sequence 2: NP_495185.1
• Gene: vrk-1 / 174004
• WormBaseID: WBGene00017895
• Length: 610
• Species: Caenorhabditis elegans
• Alignment Length: 748
• Identity: 150/748 - (20%)
• Similarity: 277/748 - (37%)
• Gaps: 204/748 - (27%)

  Fly   151 AKESVKMTSEDLLQPGH----VVKERWKVVRKIGGGGFGEIY----EGQDLITREQVALKVE-SA 206
            ||:..::.:|  ::.||    :.|:.:.|.::...||||.|:    ||:.    :|:.:|:| |.
 Worm     8 AKKLHELAAE--VRVGHKINDISKKTFIVGKQFATGGFGRIHTCTEEGKS----QQMVMKIEPST 66

  Fly   207 RQPKQVLKMEVAVLKKLQGKEHV--------CRFIGCG----------RNDRFNYVVMQLQGKNL 253
            ..|   |..||.|..::..||.:        ..:||..          .:::..|:::.....:|
 Worm    67 NGP---LLTEVVVFNRILKKELIESYKKKKKISWIGLPYLIANGYFTYESEKMRYMIIPKYATSL 128

  Fly   254 AELRRAQPRGAFSLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVY----ML 314
            ..:|... .|..::..:|.:...||.|:|.:|...:.|.|:|.:|..:.:     :.||    ::
 Worm   129 EAVRETN-GGTLAMKDSLTVASCILDALEYLHESDYAHADVKAANILLEK-----QGVYSTAVLV 187

  Fly   315 DFGLARQYTTGTGEVRCPRAAAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVNGQLPWR 379
            |||||.:.|....:   |.......||..:.|.:|||........|:..|.|.|:.:..|.|||.
 Worm   188 DFGLAHRTTNNVDK---PDKKRAHNGTCIFTSTDAHRGNNPSFRGDIEILAYNLMMWATGTLPWM 249

  Fly   380 KIKDK-EQVGLTKEKYDHRILLKHLPSDLKQFLEHIQSLTYGDRPDYAMLIGLFERCMKRRGVKE 443
            .::.. |:|...|:|:     :..||..|:..|::..|...|      .:..:|:..||.....:
 Worm   250 ALESSPEKVFDAKQKF-----IAGLPGTLQNVLKNESSAVVG------CIASMFDISMKTNYTDK 303

  Fly   444 SDPYDWEKVDSTAIGNISATGNPSIPIKSDYMHGNITQMTVAASNASGTEYIRKRAEIETAHIT- 507
            .|....:|:.:.||...|:.|..: |.:.                       :|.||.:...:|
 Worm   304 VDMGKLKKLVTDAIQKTSSDGKKT-PTRQ-----------------------KKLAEEDKNAVTP 344

  Fly   508 --ATDPLNIKEKVDKNCNATSLAQPAKGSGEPMVQHGNAANNQNITSKGLQQQSTLTNSQVAIAN 570
              :|..|.:||:.|...|.....:|.|          .|...:..|.|.::..:...:::....|
 Worm   345 KRSTRRLAVKEESDNKDNDEVEVKPEK----------KATPRKRTTRKAVEVNNDSDDNEEQYEN 399

  Fly   571 IQSAPSMIEREDVQYTKLEEGAPTKFITMKPNGECDNVDIAAKCIFEQKHVEANDDIVGRASLSG 635
            .:|..|..:                  |.....:.::||            :..:.|:.::|.|
 Worm   400 PKSKSSRTQ------------------TKSKRAKEEDVD------------DEEEIIIPKSSRS- 433

  Fly   636 VEQHYKSQIKKHNSPEIANKQIQRTGTVTNDKTSEVNRSTEEQKSTFGRLRVLTAPPMSVHDLPS 700
                              ..::|.:|..::..|.....||...:|    :|:         .|.|
 Worm   434 ------------------RSKVQLSGEGSDVTTPSSAASTSRSRS----IRL---------GLTS 467

  Fly   701 GGGHSHQVSD--------LSGKQDPYAATSNAAPIGINSSSTKFGSQHGQIFGLAAMPPINRRSA 757
            ....|::|:.        ||..:      |:..|:.|:.:|.|              .|.....:
 Worm   468 STASSNKVAKKIEQKYKRLSMNK------SSLVPVTISVASDK--------------SPTTSTPS 512

  Fly   758 TSTNLRPSSSASQRINSGSTIGGAV--GNGSNTARSSVAGDHSVTQFALIDDENVSALQQVTKGG 820
            :|:.||....:|:.:..|.|:...|  ......|::. :|..|.|:.:..:...|..::...||.
 Worm   513 SSSGLRSKRKSSEDVGEGITLKTQVLITPAIKKAKTK-SGISSATKASPTELRRVPGVRNFPKGR 576

  Fly   821 AL------------TLAS-QWKSQFDDSEDTTD 840
            ..            .||| |.|..||||..:::
 Worm   577 RSMIIKETSAKYKERLASRQTKPTFDDSSCSSE 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asator	NP_651924.2	STKc_TTBK	172..433	CDD:270919	68/288 (24%)
vrk-1	NP_495185.1	Protein Kinases, catalytic domain	26..312	CDD:473864	73/312 (23%)
		PLN02967	341..>445	CDD:215521	23/162 (14%)