Protein Alignment CaMKI and PSKH2

DIOPT Version :10

• Sequence 1: NP_524622.1
• Gene: CaMKI / 43792
• FlyBaseID: FBgn0016126
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: XP_016869418.1
• Gene: PSKH2 / 85481
• HGNCID: 18997
• Length: 504
• Species: Homo sapiens
• Alignment Length: 362
• Identity: 141/362 - (38%)
• Similarity: 206/362 - (56%)
• Gaps: 52/362 - (14%)

  Fly     5 GKKDSGKKAKAKDLKELNK-QVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKAL 68
            |||.:|..|        || :.|...:|::..|:|||:||.|...|.|.:. :.||:|:::.:..
Human   163 GKKRAGAAA--------NKGRNSYLRRYDIKALIGTGSFSRVVRVEQKTTK-KPFAIKVMETRER 218

  Fly    69 KGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDR 133
            :|:|..: :|:.||||.|               |..||||:|.:|.:.:||:||||.||||||||
Human   219 EGREACV-SELSVLRRVS---------------HRYIVQLMEIFETEDQVYMVMELATGGELFDR 267

  Fly   134 IVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLS---KM 195
            ::.:||:||:||..:::.:.:.:.|:|...:.||:|||||||||.|.::|||:|:||||:   |.
Human   268 LIAQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKK 332

  Fly   196 EDSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGD 260
            .....|.|.||||.|:|||||.:|||..|||:|::|||:|.||.|:.||.||:...|:.:||||.
Human   333 SGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGK 397

  Fly   261 FEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASS--RNIHGTVSEQLKKN 323
            :.:....|..||..||.||..|:.:....|.:..|||.|.|:....|.|  :|:...:|..|
Human   398 YNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMAAGSSMKNLQRAISRNL--- 459

  Fly   324 FAKSRWKQAYYAATVIRQMQRMALNSNSNANFDSSNS 360
                              |||.:.:|.|..:..||.|
Human   460 ------------------MQRASPHSQSPGSAQSSKS 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	119/276 (43%)
PSKH2	XP_016869418.1	Protein Kinases, catalytic domain	181..439	CDD:473864	119/274 (43%)