Protein Alignment CaMKI and PHKG2

DIOPT Version :10

• Sequence 1: NP_524622.1
• Gene: CaMKI / 43792
• FlyBaseID: FBgn0016126
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: NP_000285.1
• Gene: PHKG2 / 5261
• HGNCID: 8931
• Length: 406
• Species: Homo sapiens
• Alignment Length: 294
• Identity: 110/294 - (37%)
• Similarity: 163/294 - (55%)
• Gaps: 32/294 - (10%)

  Fly    29 EKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLE-------NEIRVLRRFS 86
            :||:...::|.|..|.||....: :.|..|||||::..|.:...|.||       .|..:||:.:
Human    22 QKYDPKDVIGRGVSSVVRRCVHR-ATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVA 85

  Fly    87 ANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQ 151
            .              ||:|:.|:::||..|.::||.:|:..|||||.:.||.:.:||:...::|.
Human    86 G--------------HPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRS 136

  Fly   152 ILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLS-KMEDSGIMATACGTPGYVAPEV 215
            :||||.::|...:|||||||||:|.   ||:.:|.:||||.| .:|....:...||||||:|||:
Human   137 LLEAVSFLHANNIVHRDLKPENILL---DDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEI 198

  Fly   216 L------AQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISES 274
            |      ....|||.||:|:.|||.:.||.|.|||:......:...|::|.::|.||.||:.|.:
Human   199 LKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSST 263

  Fly   275 AKHFIKNLMCVTVEKRYTCKQALGHAWISGNEAS 308
            .|..|..|:.|..|.|.|.:|||.|.:....|.|
Human   264 VKDLISRLLQVDPEARLTAEQALQHPFFERCEGS 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	108/285 (38%)
PHKG2	NP_000285.1	STKc_PhKG2	13..291	CDD:271083	108/286 (38%)
		Calmodulin-binding (domain-N). /evidence=ECO:0000250	306..330
		Calmodulin-binding (domain-C). /evidence=ECO:0000250	346..370