Protein Alignment CaMKI and CHEK2

DIOPT Version :10

• Sequence 1: NP_524622.1
• Gene: CaMKI / 43792
• FlyBaseID: FBgn0016126
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: XP_011528141.1
• Gene: CHEK2 / 11200
• HGNCID: 16627
• Length: 596
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 116/307 - (37%)
• Similarity: 172/307 - (56%)
• Gaps: 32/307 - (10%)

  Fly    26 SIEEKYNLHGLLGTGAFSEVRLA-ESKDSPGEHFAVKIIDKK--ALKGKEE-----SLENEIRVL 82
            ::.::|.:...||:||..||:|| |.|..  :..|:|||.|:  |:....|     ::|.||.:|
Human   268 ALRDEYIMSKTLGSGACGEVKLAFERKTC--KKVAIKIISKRKFAIGSAREADPALNVETEIEIL 330

  Fly    83 RRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASH 147
            :               :|.||.|:: ::.:.|....|:|:||:.||||||::|......|.....
Human   331 K---------------KLNHPCIIK-IKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKL 379

  Fly   148 LIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSK-MEDSGIMATACGTPGYV 211
            ...|:|.||.|:||.|::||||||||:|..|.::|..|.|:|||.|| :.::.:|.|.||||.|:
Human   380 YFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYL 444

  Fly   212 APEVLAQ---KPYGKAVDVWSIGVISYILLCGYPPFYD-ENDANLFAQILKGDFEFDSPYWDEIS 272
            |||||..   ..|.:|||.||:|||.:|.|.|||||.: ....:|..||..|.:.|....|.|:|
Human   445 APEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVS 509

  Fly   273 ESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQ 319
            |.|...:|.|:.|..:.|:|.::||.|.|:. :|...|.....:||:
Human   510 EKALDLVKKLLVVDPKARFTTEEALRHPWLQ-DEDMKRKFQDLLSEE 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	111/286 (39%)
CHEK2	XP_011528141.1	FHA_CHK2	103..257	CDD:438718
		STKc_Chk2	266..539	CDD:270986	111/288 (39%)