DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31998 and Prrt3

DIOPT Version :9

Sequence 1:	NP_726548.1	Gene:	CG31998 / 43774	FlyBaseID:	FBgn0051998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_001276628.1	Gene:	Prrt3 / 210673	MGIID:	2444810	Length:	972	Species:	Mus musculus

Alignment Length:	981	Identity:	180/981 - (18%)
Similarity:	294/981 - (29%)	Gaps:	360/981 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 ERSVAAVLIKVAYGTTSTTKRSIPDTSYSLG----------------LTTVATPFLTTQRYHSSH 224
            ||.:.|..:::|...||......||:...|.                :||..:..|:.....::.
Mouse    98 ERLLRADDLQLARAFTSQGWTGPPDSQELLEPEAPEPHPVRAPRLTLVTTTPSSLLSAAILSTAS 162

  Fly   225 QQHG--VGGRP-KNYELDLERDHALPTSAPNADILKSNNNPTYPNPNRHHSHDRDRHRNVVLHSS 286
            |:.|  .|.:| :|.||.:.:.....|.|...|...|::.|.         .:.|..|.:|
Mouse   163 QKPGGTAGQQPARNEELIMVKAETHITQASPWDFQGSSHTPV---------PETDAVRTLV---- 214

  Fly   287 TPIPSIPNLLKKING--------AQPPTI----PMYPGDIPSYSPPSRAFFTPPLPPEYQNPFAD 339
                     |.|..|        .|.|.:    |:.||  ...:||.:...||       .|.|.
Mouse   215 ---------LGKQGGHEQGFQEAVQGPLLTQQDPVVPG--VGSTPPVKVESTP-------EPGAQ 261

  Fly   340 KPTLRGTNNEGLIAVNRRPIPPPSLMPSQDRIPIRPPDLGSNNNDAVVN-----SMTDL------ 393
            .         .|..|...|:|        :.:|..||..|:.:...|.:     ..|||
Mouse   262 L---------DLALVRSLPLP--------EGLPAEPPKTGAGDTWEVSSLGPQPEQTDLLGGQDS 309

  Fly   394 ----NYAPSGMDAKHRLEENFAHGTVSDISGVERIKALNTPARASGEEYLYEKASSAKGQGSYEV 454
                ...||..|.    .:......||.::|.:.|    :|.|.               :|:.|
Mouse   310 PAPQPIPPSASDT----SDGHLRPAVSSLNGADPI----SPQRV---------------RGAME- 350

  Fly   455 DAIGPNKRQEVLPNIRRILGSKNGDIPAVLLKHVTQRPIITLRQPPSSPIVLIEKSTSNEEIIDA 519
               .|...:..:|::.....:.||          |:.|:..| ||
Mouse   351 ---APGTPKSFIPDLPNSAQAANG----------TESPVRAL-QP-------------------- 381

  Fly   520 DAPSVVSPNINHSKYHPGQLEYYENATAGTTPSAAAAIGDVSATSFSYATTNA-GQPGHTGKTTD 583
                      :.::..||:.:.:..|.....||.:.. |.|..|     |..| |||.....:..
Mouse   382 ----------DEAEDWPGRPQSHPPAPPVQAPSTSRR-GLVRVT-----TQRALGQPLPPEPSAS 430

  Fly   584 AIRELGTGVPDQNPIGAAAAATVHTTW-------AWAWNIHIYLSVVLF---TILSVYSLYKLLT 638
            :|    ..:|..:|...|.|..:.  |       :::|.:|:|...|||   .:|::.::...|.
Mouse   431 SI----VPIPASSPPANATAPPLR--WGPLRRVLSFSWELHVYGVGVLFLLPALLALVTVAAALA 489

  Fly   639 YNKLTHLFAQAYFVCINLILIMICILRIFFLCFDAYNVHGSFNLFTSELFLNLPSTFLTVAFSVL 703
            ..:|. |.|.|       ::::...||..::..|.|.......:....:..|||...|..|.:.|
Mouse   490 GPRLA-LVAAA-------LVLVASGLRSAYMLTDPYGSQARLGVRAGLVLYNLPFPLLLTALAAL 546

  Fly   704 ILFLFLKSLNHKNNRYSALIRPLTVVVGCGVHVVLCITLHYVESYTLKNHHLYFQQQQQQQYFRR 768
            .|......|.      ..|.:||.:.:...||
Mouse   547 TLLGLGAGLP------QPLQKPLLLGIVAPVH--------------------------------- 572

  Fly   769 QQLYNQQGQPTATMSPSAILPPPPRVLTLICQIIYIFICLSLGLLYLYIYRILKRILRSKSQNYI 833
                     .|..::.......|  ||.|:.|.:......|:.|..|.:.|  :|:|...
Mouse   573 ---------GTCLLATDLFSTSP--VLNLLTQGLSCAWGASVALGTLCLCR--RRLLEGP----- 619

  Fly   834 HGYQNLSYAIHITIATALLFVLLAALQIFGAIYISCRHTSIVDVDWLQWGYQFSLRLIE------ 892
            .|: :.|....:......|.:|.:.||:..::::...........|..||..|.|||:|
Mouse   620 RGW-DASPGPRLLAVAGSLGLLASGLQLAASLWLYPGPGREGRFSWAWWGVHFWLRLLELTWALA 683

  Fly   893 IAIITLMS-----------WVAGL---------KTSVEHDSLSAVAGDVRMIGSGMGAYGQDGGT 937
            :|:..|.:           |...|         |:.|.....:..||.     ||:|..|.|
Mouse   684 LALAALAATRPRPPTEHACWAKLLRLACPAPTGKSEVPERPNNCYAGP-----SGLGTGGLD--- 740

  Fly   938 PNNAIREKHVGNGTGTHNSNVTNFFLPCTSSSSQEHFETDYPAVCNANTNLHTYTMRTGKLIYDD 1002
                |.:..:.|..|...       ||.|..|
Mouse   741 ----ISKSLIRNAAGEAG-------LPVTPGS--------------------------------- 761

  Fly  1003 SYALNSMGP--TTATTSNARPCEYQLQEPMYQRPYDTGSIG-------------STLNQQHQLNQ 1052
                   ||  :.|:....||...::..         ||:|             |.:|....::.
Mouse   762 -------GPWGSAASLGRGRPGGQRMSR---------GSVGPAPSLSELDLRPPSPINLSRSIDA 810

  Fly  1053 MRFQEH 1058
            ..|:||
Mouse   811 ALFREH 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31998	NP_726548.1	EXS	610..>724	CDD:296120	26/123 (21%)
Prrt3	NP_001276628.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..94
		PHA03247	<64..464	CDD:223021	93/493 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..137		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..256		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..800		12/101 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	833..856
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	928..972
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28K70
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900