DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31998 and Prrt4

DIOPT Version :9

Sequence 1:	NP_726548.1	Gene:	CG31998 / 43774	FlyBaseID:	FBgn0051998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_001094913.1	Gene:	Prrt4 / 101359	MGIID:	2141677	Length:	902	Species:	Mus musculus

Alignment Length:	949	Identity:	178/949 - (18%)
Similarity:	293/949 - (30%)	Gaps:	304/949 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 TIPMY------PGD-IPSYSPPSRAFFTP---PLPPEYQNPFA---DKPTLRGTNNEGLI----A 353
            |.|::      ||: :|.:. .:...|||   .||||..:..:   .:||.......|.:    |
Mouse    95 TDPLWELLVGSPGNYLPEWG-SAEGSFTPWASSLPPESTSRLSGPTKRPTAHSQPRMGTVTWATA 158

  Fly   354 VNRRPIPPPSLMPSQDRIPIR---------PPDLGSNNNDAVVNSMTDL-----NYAPSGMDAKH 404
            :.....|..:..|.|..:.::         .|.||..:...:.:....|     ...|.|
Mouse   159 LTATAPPTSAPRPHQSELELKFDVALRAGAAPTLGHRSLPLLPSLRASLAEIAGRLGPFG----- 218

  Fly   405 RLEENFAHGTVSDISGVERIKALNTPARASGEEYLYEKASSAKGQGSYEVDAIGPNKRQEVLPNI 469
                 |...|||.:....|.....|.|..|   :.:|.:.|                     |.:
Mouse   219 -----FFGTTVSPLRNFSRQSYPGTTAHPS---FAFEVSDS---------------------PGL 254

  Fly   470 RRILGSKNGDIPAVLLKHVTQRPIITLRQPPSSPIVLIEKSTSNEEIIDADAPSVVSPNINHSKY 534
            ....||                     |.||     |:|:..|:..::|    ||.||:....|.
Mouse   255 FGTTGS---------------------RPPP-----LLERKFSSPSLLD----SVASPSSASVKT 289

  Fly   535 HPGQLEYYENATAGTT-PSAAAAIGDVSATSFSYATTNAG-QPGHTGKTTDAIRELGTGVPDQNP 597
            .|.|    ::.|..|: |.      ::|..||...:|..| :||...: .:.:.:||.  |..:|
Mouse   290 TPVQ----QDPTVSTSGPD------ELSPASFGNPSTQPGCEPGSCSE-PELLDDLGQ--PPASP 341

  Fly   598 IG------AAAAATVHTTWAWAWNIHIYLSVVLFTILSVYSLYKLLTYNKLTHLFAQAYFVC--- 653
            :.      .|..|.....|..||..|:|.:..||.::::.:|..|          |...:.|
Mouse   342 LPLFFLTLEADWAEARARWGLAWEAHVYGAGALFGLVALLALLAL----------ALLPWRCPPG 396

  Fly   654 ------INLILIMICILRIFFLCFDAYNVHGSFNLFTSELFLNLPSTFLTVAFSVLILFLFLKSL 712
                  ::|:|:.....|.|.|.:|||............|..:||...|.....:..|.
Mouse   397 APCLALLDLLLLSAGTTRAFPLFYDAYGHRDRLPTLVWLLLQDLPLPCLAAGLGLACLL------ 455

  Fly   713 NHKNNRYSALIRPLTVVVGCGVHVVLCITLHYVESYTLKNHHLYFQQQQQQQYFRRQQLYNQQGQ 777
                     |.||.|.....|:..:|.:.|                                 |.
Mouse   456 ---------LARPRTPRCPAGLAALLLLGL---------------------------------GL 478

  Fly   778 PTATMSPSAILPPPPRVLTLICQIIYIFICLSLGLLYLYIYRILKRILRSKSQNYIHGYQNLSYA 842
            ..|....||: ..|.|.|.|..:.::.|:...|..|.|.:.....|..|:.:.....|::..:..
Mouse   479 AAAAALGSAV-HRPLRPLRLASRGLHAFLAAFLSGLLLALSCWGGRRRRAGAPLGGAGFKGATPV 542

  Fly   843 IHI---------------TIATALLFVLLA-ALQIFGAIY-ISCRHTSIVDVDWLQWGYQFSLRL 890
            ..:               |...|..|.||: |||.:..:: :.....:.::..|..|.:|..|||
Mouse   543 PQVRSPFAPRESWRRAARTAPVAGTFGLLSGALQGYEVLHALGYGSQAGLEGPWPWWAFQLGLRL 607

  Fly   891 IEIAI---ITLM---------------------------------SWVAGL-----------KTS 908
            .|:.:   :.|:                                 .||.|:           :..
Mouse   608 GEVGVALPLALLGLYPALCSPRVPRRCWAKLFRLSPGHAAPLLPGGWVPGIPDKEPLGSAIARGD 672

  Fly   909 VEHDSLSAVAG---DVRMIGSGMGAYGQDGGTPNNAIREKHVGNGTGTHNSNVTNFFLPCTSSSS 970
            .|...|.|:||   |:.:.|.|...:...|..|..:.        ..:.:|:.|..|.|.:..:.
Mouse   673 AELLQLCALAGPGPDLLLQGGGCRGFEGAGANPTQST--------ASSPSSDCTVDFRPPSPINL 729

  Fly   971 QEHFET-------------DYPAVCNANTNLHTY-TMRTGKLIYDDSYALNSMGPTTATTS-NAR 1020
            :...|.             ..||...|...|..| |:..|..|        ..||:..:.: ...
Mouse   730 RRSIEEALCSEALLAPGLFQGPAFGEALPGLGLYRTISLGNKI--------GAGPSEKSENVPGS 786

  Fly  1021 PCEYQLQEPMYQRPYDTGSIGSTLNQQHQLNQMRFQEHP---------TYMSTDYMTDSGPDHYE 1076
            |...:|..|....|..:.|.||........:.|.....|         ..:|....::|.|
Mouse   787 PAPPELPSPGAWPPGSSASSGSLCGLSRDSSSMLLCSSPDRPPRCPLVCVLSPPRPSESSP---- 847

  Fly  1077 NPNFSLHSTATEQ----KRRDYDQNEVSFNSNSGALQQQ 1111
                ||.::.:.|    ..||..::.....:....||:|
Mouse   848 ----SLPASGSYQALSPPSRDSPEHASELQAEEALLQEQ 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31998	NP_726548.1	EXS	610..>724	CDD:296120	25/122 (20%)
Prrt4	NP_001094913.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..92
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..149		8/27 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..333		15/62 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..723		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	774..811		9/36 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	839..872		7/40 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28K70
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900