Protein Alignment faf and USP34

DIOPT Version :10

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: NP_055524.3
• Gene: USP34 / 9736
• HGNCID: 20066
• Length: 3546
• Species: Homo sapiens
• Alignment Length: 2841
• Identity: 571/2841 - (20%)
• Similarity: 935/2841 - (32%)
• Gaps: 1004/2841 - (35%)

  Fly     7 RHTTGQPGSTAPSSSSSTTSTTTTTTSPAQSAGS---------------------------GSGI 44
            |.|...|.|.|.|..||..|.|      .||.||                           ||..
Human   508 RRTAPSPWSPAASPQSSDNSDT------HQSGGSDIEMDEQLINRTKHVQQRLSDTEESMQGSSD 566

  Fly    45 GTGTGTVANSSLPGGGSGSLDGNQDQ-----------QPATDSQSSD--DVAASLSANSVDSTIT 96
            .|.......||.||..||..||:.::           .|.::.||.|  |:.| |.....|....
Human   567 ETANSGEDGSSGPGSSSGHSDGSSNEVNSSHASQSAGSPGSEVQSEDIADIEA-LKEEDEDDDHG 630

  Fly    97 IVPPEKLISSFPTTKLRSLTQKISNPRWVVPVLPEQELEVLLNAAIELTQAGVD-HDCEPCVEFY 160
            ..||:    |...|.||:                 ::||         :|||:. .|.:...|
Human   631 HNPPK----SSCGTDLRN-----------------RKLE---------SQAGICLGDSQGMSE-- 663

  Fly   161 RNGLSTSFAK--ILTDEAVNSWKNNIHHCILVSCGKLLHLIAIHMQRDNPYLLDLLAIVFDPENK 223
            |||.|:...|  :...|::.|..|.:.                        :||..:...|||:.
Human   664 RNGTSSGTGKDLVFNTESLPSVDNRMR------------------------MLDACSHSEDPEHD 704

  Fly   224 FN-TFNA-----GRQPECFAAPDYIWGQLDSNKMYARPPPEPKNAR------------------- 263
            .: ..||     |.|..|........|:...|:::        |.|
Human   705 ISGEMNATHIAQGSQESCITRTGDFLGETIGNELF--------NCRQFIGPQHHHHHHHHHHHHD 761

  Fly   264 GWLVDLINRFGQLGGFDNLLERFNIGLELLKRNQNKCTGKNISVEGRVENGAQDNRLTLALIHSL 328
            |.:||                      ::|..:...|:...:|.:.  |....|
Human   762 GHMVD----------------------DMLSADDVSCSSSQVSAKS--EKNMAD----------- 791

  Fly   329 LRPFGQCYELLMPATIAKYFMPTWNVVLDLLDSFTDEELKREVKPEGRNDYINGIVKSARLLASR 393
                                             |..||
Human   792 ---------------------------------FDGEE--------------------------- 796

  Fly   394 LTGQEELIRDLEMFRLKMILRLLQVSSFNGKMNALNEINKVLSSVAYFSHRSQ-PL--PHCMPED 455
             :|.||              .|:|::|.....:.|.:....|:|: |..|.|| |:  .|....:
Human   797 -SGCEE--------------ELVQINSHAELTSHLQQHLPNLASI-YHEHLSQGPVVHKHQFNSN 845

  Fly   456 EMDWLTADRMAQWIKSSDVLGVVLKDSLHQPQYVEKLEKIIRFLIKEQALTLDDLDAVWRAQAGK 520
            .:..:..|.:.:  |.:.:|..:::|                    |.|:.|.
Human   846 AVTDINLDNVCK--KGNTLLWDIVQD--------------------EDAVNLS------------ 876

  Fly   521 HEAIVKNVHDLLAKLAWDFTPEQLDHLFEAFQASMTTANKRQRERLLELIRRLAEDDKNGVMAQK 585
             |.::.....||..|...||..|:                  |.|.:|.......::::.|::.:
Human   877 -EGLINEAEKLLCSLVCWFTDRQI------------------RMRFIEGCLENLGNNRSVVISLR 922

  Fly   586 VL-KLFWTLAHSQEVPPEVLDQALGAHVKILDYSCSQERDAQKTIWLDKCVDELKSGDGWVLPAL 649
            :| |||.|.            |..|:              :..|.|:..          |.
Human   923 LLPKLFGTF------------QQFGS--------------SYDTHWITM----------WA---- 947

  Fly   650 RLIRDICCLYDTTTNHAQRTQTSTNRQQVIERLQNDYSLVILVTNSLTAYMEKVRQMVTDSPGLD 714
                                             :.:.:::.|..::|..|::.||
Human   948 ---------------------------------EKELNMMKLFFDNLVYYIQTVR---------- 969

  Fly   715 ATRILIDGR-----FPHHVQIAERLEFL----KFLLKDGQLWLCADQAKQIWHCLAVNAVFPADR 770
                  :||     :.|..::..||:||    ..|.......|..:|...:||||       .:.
Human   970 ------EGRQKHALYSHSAEVQVRLQFLTCVFSTLGSPDHFRLSLEQVDILWHCL-------VED 1021

  Fly   771 EECF----RWFGKLMGEEPDLDPGIN--KDFFENNILQLDPHLLTESGIKCFE---RFFKAVNSK 826
            .||:    .||...:..:.....|:.  |..|...:.||.|..::.:|:..|:   ...:...|.
Human  1022 SECYDDALHWFLNQVRSKDQHAMGMETYKHLFLEKMPQLKPETISMTGLNLFQHLCNLARLATSA 1086

  Fly   827 EDKLKAIHRGYMLDNEDLIGKDYLWRV-ITTGGEEIASKAIDLLKEV----STALGPRLQENIAE 886
            .|.         ..|.:|.|.|..|.: :.....:::..||..:...    .|.|         |
Human  1087 YDG---------CSNSELCGMDQFWGIALRAQSGDVSRAAIQYINSYYINGKTGL---------E 1133

  Fly   887 FHEMFIGECCSRLRTHYGNIVILGKTQLQEELDAPDQSDNTNDESKDSKMRFIEAEKMCRILKVL 951
            ..:.||.:|...|        ::..:.|::|              ..|.:..||     |.|.:|
Human  1134 KEQEFISKCMESL--------MIASSSLEQE--------------SHSSLMVIE-----RGLLML 1171

  Fly   952 QEYVKECDRSFS--------------------GDRVHLPLSRVTR-----GKNTI-LYIRFQNPG 990
            :.:::...|.|:                    .|:..|||..|.:     .|.|| :|     |.
Human  1172 KTHLEAFRRRFAYHLRQWQIEGTGISSHLKALSDKQSLPLRVVCQPAGLPDKMTIEMY-----PS 1231

  Fly   991 RSIDDMEI-VTHSNETMAAFKRNLLKRIKGTSTANIK----------VDLFYANDEMIGVSDEIN 1044
            ..:.|:.. |||..|.:...:.|...:::....:|.|          |.:..:..|:....|| .
Human  1232 DQVADLRAEVTHWYENLQKEQINQQAQLQEFGQSNRKGEFPGGLMGPVRMISSGHELTTDYDE-K 1295

  Fly  1045 PLYQYTIRDKMNLTAKLTPVGTGLASSPDSSSDSSTGSPPRPC-PDMQRVESESTLPGVIISQNY 1108
            .|::...:|...:...|        .:|...........|..| |..|:    ..:|.:::.|..
Human  1296 ALHELGFKDMQMVFVSL--------GAPRRERKGEGVQLPASCLPPPQK----DNIPMLLLLQEP 1348

  Fly  1109 QYTEFFLKLYQLGS-----------DLEHGRLRD--------SAKV--LLHLLP-C--------- 1142
            ..|..|..|..|.|           |.|..|..:        |.:|  ||.||| |
Human  1349 HLTTLFDLLEMLASFKPPSGKVAVDDSESLRCEELHLHAENLSRRVWELLMLLPTCPNMLMAFQN 1413

  Fly  1143 --DRQT--------IRQLKIMCKVPKAAVTVAVTGDKIAKDEEEK------LYPTEQAGIEDEEE 1191
              |.|:        :.::|...|:..|...:...|....:...|.      |||......||:.|
Human  1414 ISDEQSNDGFNWKELLKIKSAHKLLYALEIIEALGKPNRRIRRESTGSYSDLYPDSDDSSEDQVE 1478

  Fly  1192 H------CTPEQMFLHPTPAQVLYNLSVLH-GLLIPALDPLGESALLVQSAW--MHSGCAHFVLE 1247
            :      |    .|:.....|.|  |.:.: |:|.|.          .|.:|  ....|...:|:
Human  1479 NSKNSWSC----KFVAAGGLQQL--LEIFNSGILEPK----------EQESWTVWQLDCLACLLK 1527

  Fly  1248 LLTKNNFLPS---------------ADMHTKR-------------ASFQCVLRLAKLFLYIVGSV 1284
            |:.:....||               |:.|.||             |....:.||.::||.:|
Human  1528 LICQFAVDPSDLDLAYHDVFAWSGIAESHRKRTWPGKSRKAAGDHAKGLHIPRLTEVFLVLV--- 1589

  Fly  1285 LSRVGDEPMICDLDNGSRSQVDILKQNFSTMPSSSQGTLRAISAKLAVILAREMLSASPEGDRC- 1348
                                               |||          .|.:.::|.:...|..
Human  1590 -----------------------------------QGT----------SLIQRLMSVAYTYDNLA 1609

  Fly  1349 -RTLFSSTLQWSCPDISTIKAVVQLAWASSCGNLQALGNSSGDFEDEVIVPDGQDFSMCKEALEV 1412
             |.|.:.:...|..::|.....:.::||..|                         |:.|.:|
Human  1610 PRVLKAQSDHRSRHEVSHYSMWLLVSWAHCC-------------------------SLVKSSL-- 1647

  Fly  1413 LTISFILNPSANEALTSD--PNWPKFITSIVLKNPLRHVRQVASEQLFLASTYCAGD--RRPFVY 1473
                          ..||  .:|.|.:|.::.:..:||.......:|.| |....||  .|.|:.
Human  1648 --------------ADSDHLQDWLKKLTLLIPETAVRHESCSGLYKLSL-SGLDGGDSINRSFLL 1697

  Fly  1474 MV--NLL-----VGALKTL-VPQYEST------CAEFFSVLCRTLSYGCIYNWPLQISEGL---- 1520
            :.  .||     ..|||.: :..||..      |.|:|.:||:.:.       .:.|.:..
Human  1698 LAASTLLKFLPDAQALKPIRIDDYEEEPILKPGCKEYFWLLCKLVD-------NIHIKDASQTTL 1755

  Fly  1521 ---------LGDEIKWLQRIRENV-HATGDTQVHEELLEGHLCLAKELM-----FFLGADSKAQL 1570
                     |.|.|    |.||.: |..|:  |.::.|.|.|.||..::     |....:.:..|
Human  1756 LDLDALARHLADCI----RSREILDHQDGN--VEDDGLTGLLRLATSVVKHKPPFKFSREGQEFL 1814

  Fly  1571 NELIHELIDDFLFTASREFLHLRRHGSLRQDTVPPPVCRSPHTIAAACDLLIALCQLCVPNMKLL 1635
            .::.:.|   ||..:.::          ||.    |.|:|..:.|||.|||:.:.:..|.|.:|:
Human  1815 RDIFNLL---FLLPSLKD----------RQQ----PKCKSHSSRAAAYDLLVEMVKGSVENYRLI 1862

  Fly  1636 TNTLIDFVCTDTDPLREWDYLPPVGARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAH 1700
            .|.::........|.: |||.|....|....|.||.|.|||||:.|.:|||||:|..|
Human  1863 HNWVMAQHMQSHAPYK-WDYWPHEDVRAECRFVGLTNLGATCYLASTIQQLYMIPEAR------- 1919

  Fly  1701 GAATTDGEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAI 1765
                                  .|:|:...|                .|::   |...|..:|.:
Human  1920 ----------------------QAVFTAKYS----------------EDMK---HKTTLLELQKM 1943

  Fly  1766 FAHLGHSALQYYVPRGLWTHFKLLGEPVNLREQQDAVEFFMSLLESLDEGLKALGQPQLMN---A 1827
            |.:|..|..:.|.||.....:.:..:|:|..||:|..|||..|:..::|     ..|:|.|   :
Human  1944 FTYLMESECKAYNPRPFCKTYTMDKQPLNTGEQKDMTEFFTDLITKIEE-----MSPELKNTVKS 2003

  Fly  1828 TLGGSFSDQKICQECPHRYSKEEPFSVFSVDIRNHSSLTESLEQYVKGELLEGADAYHCDKCDKK 1892
            ..||..::..:..:|.|.....|.|......:.:..::.|||::....:.|||.:.|.|..|.||
Human  2004 LFGGVITNNVVSLDCEHVSQTAEEFYTVRCQVADMKNIYESLDEVTIKDTLEGDNMYTCSHCGKK 2068

  Fly  1893 VVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDMEPYT---VSGLAKLEGEV 1954
            |...||.|.||||.:|:....|:.::...:...|.|.:|.||..|||.|||   :.|.::.:...
Human  2069 VRAEKRACFKKLPRILSFNTMRYTFNMVTMMKEKVNTHFSFPLRLDMTPYTEDFLMGKSERKEGF 2133

  Fly  1955 VEVGDNCQTNVETTKYELTGIVVHSGQASGGHYFSYILS-KNP---ANGKCQWYKFDDGEVTECK 2015
            .||.|:.:.: |:.:|:|.|:.||:|.|.||||:|:|.. .||   .|.|  ||.|:|.||   |
Human  2134 KEVSDHSKDS-ESYEYDLIGVTVHTGTADGGHYYSFIRDIVNPHAYKNNK--WYLFNDAEV---K 2192

  Fly  2016 MHEDEEMKAECFGGEYMGETYDNNLKRMQYRRQKRWWNAYMLFYTRCDQTPVQYEPSVEQLSLAE 2080
            ..:..::.:||||||...:|||:...:......::..:||||||.|       .||..|     .
Human  2193 PFDSAQLASECFGGEMTTKTYDSVTDKFMDFSFEKTHSAYMLFYKR-------MEPEEE-----N 2245

  Fly  2081 SRNMVLPLPKPIERSVRHQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELSLLG 2145
            .|.....:...:...:.|.|::||..::||...:|.|:.:|.||      .....|..:.:||:.
Human  2246 GREYKFDVSSELLEWIWHDNMQFLQDKNIFEHTYFGFMWQLCSC------IPSTLPDPKAVSLMT 2304

  Fly  2146 VQLASQFLFHTGFRTKKSLRGPVMEWYDALSHHIRSSALVRKWFANHALLSPPSRLG-------E 2203
            .:|::.|:..|...:|:  :..:::|.:.|:....:|....:||.:        |:.       :
Human  2305 AKLSTSFVLETFIHSKE--KPTMLQWIELLTKQFNNSQAACEWFLD--------RMADDDWWPMQ 2359

  Fly  2204 YILMAPSPDVRTVFVKLVV--------FFCHFAINDEPLTGYD---------GANLCEQVLISVL 2251
            .::..|:..||.:|.:|.:        ...|..:......|.|         |...|....:..|
Human  2360 ILIKCPNQIVRQMFQRLCIHVIQRLRPVHAHLYLQPGMEDGSDDMDTSVEDIGGRSCVTRFVRTL 2424

  Fly  2252 RLLKSEAA-DYGKHLPHYFSLFSMYVGLGTREKQQLLRLNVPLQFIQVALDDGPGPAIKYQYPEF 2315
            .|:..... .:.|||..||:....:..:|..|.|.||.|......:...:.. .||    :.|:.
Human  2425 LLIMEHGVKPHSKHLTEYFAFLYEFAKMGEEESQFLLSLQAISTMVHFYMGT-KGP----ENPQV 2484

  Fly  2316 SKLHQVVSHLIRCSDVSEKCQSSNQNARPLSNPFKDPNVAHEELTPLSTECMDLLFNRTGYIKKV 2380
            ..|.:            |:.:...:....||       :|.|:..|.:.|.|..|      :..:
Human  2485 EVLSE------------EEGEEEEEEEDILS-------LAEEKYRPAALEKMIAL------VALL 2524

  Fly  2381 IEDTNVGDEGLKLLQYCSWENPHFSRAVLTELLWQCG-----FAYCH-----DMRHHTDLLLNIL 2435
            :|.:. .:..|.|.|              |::....|     |.:.|     ::|...:|:.::.
Human  2525 VEQSR-SERHLTLSQ--------------TDMAALTGGKGFPFLFQHIRDGINIRQTCNLIFSLC 2574

  Fly  2436 LIDDSWQHHRIHNALNGVAEEREGLLETIQRAKTHYQKRAYQIIKCLTQLFH-------KSPIAL 2493
                     |.:|.|   ||....:|.|.....|  .:.|....|.||.|..       ..|.|.
Human  2575 ---------RYNNRL---AEHIVSMLFTSIAKLT--PEAANPFFKLLTMLMEFAGGPPGMPPFAS 2625

  Fly  2494 QMLHTNSNITRHWSI-------AVEWLQGELDRQRGIGCQYNSYSW 2532
            .:|.      |.|.:       .::||..:..|.:      .::||
Human  2626 YILQ------RIWEVIEYNPSQCLDWLAVQTPRNK------LAHSW 2659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	Ubl1_cv_Nsp3_N-like	<994..1060	CDD:475130	14/76 (18%)
		peptidase_C19C	1666..2064	CDD:239124	126/407 (31%)
		DUF3517	2198..2566	CDD:463438	70/384 (18%)
USP34	NP_055524.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..535		12/32 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	550..679		37/161 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1459..1478		5/18 (28%)
		peptidase_C19C	1892..2241	CDD:239124	126/414 (30%)
		DUF3517	2359..2692	CDD:463438	69/372 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3331..3443