Protein Alignment Zmynd8 and ZMYND8

DIOPT Version :10

• Sequence 1: NP_651881.2
• Gene: Zmynd8 / 43730
• FlyBaseID: FBgn0039863
• Length: 1664
• Species: Drosophila melanogaster
• Sequence 2: NP_001350643.1
• Gene: ZMYND8 / 23613
• HGNCID: 9397
• Length: 1241
• Species: Homo sapiens
• Alignment Length: 1397
• Identity: 353/1397 - (25%)
• Similarity: 572/1397 - (40%)
• Gaps: 359/1397 - (25%)

  Fly   300 SGEGESSLFSDASDTKTTTAKTP-------EEEAAERLALIY--EEPPTPGWDP----------- 344
            |..|.|.  .|.|.:.....|.|       :|::..|....|  ::|.|.  ||
Human    55 SSNGHSP--QDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTT--DPVDVVPQDGRND 115

  Fly   345 -FCWKCRGCGKLMPCSKCLRSFHSYCVRPATTKFDSSWKCPEC------QVIEAAPKRLRRNGVS 402
             :||.|...|:::.|..|.|.:|:.|:| .|::.:..|.||||      :.||...|.:..  ::
Human   116 FYCWVCHREGQVLCCELCPRVYHAKCLR-LTSEPEGDWFCPECEKITVAECIETQSKAMTM--LT 177

  Fly   403 VDLLSQLLSFALDRMKHV-RGAHKLRSPLEVFPLTYKKFFVNPVSFESLAQCIRNGAYQSTDEFL 466
            ::.||.||.||:.:||.. ..|.:...|||..| .|.::..:|:...:|.:..:...|..|:.||
Human   178 IEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHP-DYAEYIFHPMDLCTLEKNAKKKMYGCTEAFL 241

  Fly   467 SEVKWIQHNALILDAGDAKVEQASKAVVKVCRQEANEIDTCPECYLNA-NSSDEWFVKVCRHPHL 530
            ::.|||.||.:|.:.|:.|:.|.:|.|:|:|..|.|||:.||||||.| ...|.||.:.|.:||.
Human   242 ADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHP 306

  Fly   531 LLWAKLKGFPYWPAKAMGSSNSTLVNVRFFGKHDRAFVPVKDCFLYSAQNPNTQTSRRSARDLAE 595
            |:||||||||:|||||:...:.. |:.||||:||||:||:.:|:|.|.:.|.:....:|..:.|
Human   307 LVWAKLKGFPFWPAKALRDKDGQ-VDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSA- 369

  Fly   596 CIREVEIHIDHIKRKIGAFNYAPYRTPYDPLEEQQQLEQMMPGVYAAIDRELEPANKTPLQFLIR 660
             ::|:|:::::|:||.|.|||:|:||||.|..:.|.|              |:|.|.:.....|.
Human   370 -MQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQML--------------LDPTNPSAGTAKID 419

  Fly   661 KTADDKLSIVKKTKATESGNESDQSPSPTKKLSEVDVVSVTGSGCSDHSNVKSNNYEVISRSGES 725
            |....||:.             |.:.|| |.|....|:| .|:|
Human   420 KQEKVKLNF-------------DMTASP-KILMSKPVLS-GGTG--------------------- 448

  Fly   726 LTDSRCKVLLKRKSLAAKIVAESVETSEAVAPKRKHSLSDASFTSESSEHKRKSKHARKQHDNQD 790
                      :|.|| :.:....:.|:.:|     |:.||   ..:.:|.|..|.|.....::.|
Human   449 ----------RRISL-SDMPRSPMSTNSSV-----HTGSD---VEQDAEKKATSSHFSASEESMD 494

  Fly   791 -----NQIEEAEKTGQ-------EPPKSPTISKQNENLRDEENVIENAANDTSSASPVSASVVSV 843
                 .....:.||||       ..|.||.:|..          |....:.||:    :.|:::
Human   495 FLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAP----------ITTKTDKTST----TGSILN- 544

  Fly   844 VELVRRRQGVTITKIPREQQQTAEDTAAVPIPLPTAPPPKQNIPKGNEAANPKQSDVERQQEQLI 908
            :.|.|.:..:.:.::....||     .:.|:||                .:||:....|.|..|.
Human   545 LNLDRSKAEMDLKELSESVQQ-----QSTPVPL----------------ISPKRQIRSRFQLNLD 588

  Fly   909 KKV------IPFIEIKTEVMSEPDDEGIEEASPANQPQTDQVPLQQETITAQPES-------QMP 960
            |.:      :...||..:|.:..:....|::..::...::.:...::....:||.       ||.
Human   589 KTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMD 653

  Fly   961 AAAPAPQPKPVDNAPFEEVRIKEEILSEDEMETEQSIVSRRLKSVP---------PMPLPMPPPP 1016
            ....|.:.||   .|...|.||||:.|......:....:.:.|:.|         ..|.|.|...
Human   654 KEPSAVKKKP---KPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKD 715

  Fly  1017 PLPPREESPATADSVRFVGDTTIQRVSQKQGGKSTDTGGKRKGVQQVPIAGIPQAPSPTHSPLLS 1081
            .|..::|:.:....:....|:..:.|.......|...|.|.|..        |:.|||....:..
Human   716 KLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGREGRKNKKE--------PKEPSPKQDVVGK 772

  Fly  1082 TAPSPSASPKPTSTLAVSKPPPPPPPKGKSASHLQFRGKNDRIPTSP--PATAPPATNTSSLLRS 1144
            |         |.||...|..||..|...:|::.....|......||.  ..|||....|.|.::.
Human   773 T---------PPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKK 828

  Fly  1145 NMVVIPVEQGGSCNAHSPMTIPVPPLRAVSKNTLQNTSTGS------------------------ 1185
            ...::|.|             ..|.::.|..|:.....|.|
Human   829 QRPLLPKE-------------TAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQP 880

  Fly  1186 ---------TSSCVPS----SVSMPPPLAGLSIPPVATPTSQEESITNSGQPVGLLASALNGTAN 1237
                     |...|.:    .::..|..:.:::   .|.|.....:|:||. :..|.|::|.
Human   881 QSSQGTRYQTRQAVKAVQQKEITQSPSTSTITL---VTSTQSSPLVTSSGS-MSTLVSSVNA--- 938

  Fly  1238 DVLSSDSIPNDPITPGLATALSEMLLHTGVPKLIARPRGALRSDGSQIYPSQAGPVSQKLKENAH 1302
                  .:|       :|||.:::.  ..:.|..::...|::...::||
Human   939 ------DLP-------IATASADVA--ADIAKYTSKMMDAIKGTMTEIY---------------- 972

  Fly  1303 KITDYFISVIEDTLSDMATGDQSVLQARIAGLSLENERLKQHYDRQINDLHRTSELMISEMRKTL 1367
                       :.||...||...   |.|..|.:|.|:|:..:.::::::....||.::|||::|
Human   973 -----------NDLSKNTTGSTI---AEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSL 1023

  Fly  1368 EQEHKRVISELRQQNAIELMRAVEEAKRKQWCANCMREAQLYCCWNTSYCDYPCQQLHWPGHSAT 1432
            |||..|:|:|:::|..:|..:||:|.|:|||||||.:||..|||||||||||||||.|||.|..:
Human  1024 EQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKS 1088

  Fly  1433 CGQSVPPTIPVPPSVPTPIIEPGRAKAKVATPTATPSITNPSPSSQIMRTVAACPSAPPSANASS 1497
            |.||.  |.|           ...|.|:|.|.|...|....|.|:|          :.||..||:
Human  1089 CTQSA--TAP-----------QQEADAEVNTETLNKSSQGSSSSTQ----------SAPSETASA 1130

  Fly  1498 SKKWPPMMTLMNQSNQEAMLKLPATTYLRPVVSTTMTAPVTAPQPANNNSTNVIMAPTPPPGNNL 1562
            ||:        .:::.|...:..:|..|    |.:...|           :::::      |:|.
Human  1131 SKE--------KETSAEKSKESGSTLDL----SGSRETP-----------SSILL------GSNQ 1166

  Fly  1563 ATIISAQRNPPNY---NAKH-PNPAMPVQRFN 1590
            .::.......|.|   ...| |:|..|.|:::
Human  1167 GSVSKRCDKQPAYAPTTTDHQPHPNYPAQKYH 1198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zmynd8	NP_651881.2	PHD_PRKCBP1	345..386	CDD:277013	14/40 (35%)
		Bromo_RACK7	403..501	CDD:99940	33/98 (34%)
		PWWP_PRKCBP1	523..616	CDD:438988	41/92 (45%)
		zf-MYND	1399..1433	CDD:460312	25/33 (76%)
		PHA03247	<1427..1592	CDD:223021	36/168 (21%)
ZMYND8	NP_001350643.1	TNG2	<31..160	CDD:227367	30/109 (28%)
		PHD_PRKCBP1	117..157	CDD:277013	14/40 (35%)
		Bromo_RACK7	178..276	CDD:99940	33/98 (34%)
		PWWP_PRKCBP1	299..389	CDD:438988	41/92 (45%)
		DUF3544	449..647	CDD:463452	44/242 (18%)
		TFIIF_alpha	<629..>787	CDD:310411	38/177 (21%)
		AtpF	<984..>1051	CDD:440475	23/69 (33%)
		zf-MYND	1055..1089	CDD:460312	25/33 (76%)