Protein Alignment Zmynd8 and Zmynd8

DIOPT Version :10

• Sequence 1: NP_651881.2
• Gene: Zmynd8 / 43730
• FlyBaseID: FBgn0039863
• Length: 1664
• Species: Drosophila melanogaster
• Sequence 2: XP_006499441.1
• Gene: Zmynd8 / 228880
• MGIID: 1918025
• Length: 1266
• Species: Mus musculus
• Alignment Length: 1446
• Identity: 368/1446 - (25%)
• Similarity: 584/1446 - (40%)
• Gaps: 378/1446 - (26%)

  Fly   300 SGEGESSLFSDASDTKTTTAKTP-------EEEAAERLALIY--EEPPTPGWDP----------- 344
            |..|.|.  .|:|.:.....|.|       :|::..|....|  ::|.|.  ||
Mouse    63 SSNGHSP--QDSSTSPIKKKKKPGLLNSSNKEQSELRHGPFYYMKQPLTT--DPVDVVPQDGRND 123

  Fly   345 -FCWKCRGCGKLMPCSKCLRSFHSYCVRPATTKFDSSWKCPEC------QVIEAAPKRLRRNGVS 402
             :||.|...|:::.|..|.|.:|:.|:| .|::.:..|.||||      :.||...|.:..  ::
Mouse   124 FYCWVCHREGQVLCCELCPRVYHAKCLR-LTSEPEGDWFCPECEKITVAECIETQSKAMTM--LT 185

  Fly   403 VDLLSQLLSFALDRMKHV-RGAHKLRSPLEVFPLTYKKFFVNPVSFESLAQCIRNGAYQSTDEFL 466
            ::.||.||.||:.:||.. ..|.:...|||..| .|.::..:|:...:|.:..:...|..|:.||
Mouse   186 IEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHP-DYAEYIFHPMDLCTLEKNAKKKMYGCTEAFL 249

  Fly   467 SEVKWIQHNALILDAGDAKVEQASKAVVKVCRQEANEIDTCPECYLNA-NSSDEWFVKVCRHPHL 530
            ::.|||.||.:|.:.|:.|:.|.:|.|:|:|..|.|||:.||||||.| ...|.||.:.|.:||.
Mouse   250 ADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHP 314

  Fly   531 LLWAKLKGFPYWPAKAMGSSNSTLVNVRFFGKHDRAFVPVKDCFLYSAQNPNTQTSRRSARDLAE 595
            |:||||||||:|||||:...:.. |:.||||:||||:|||.:|:|.|.:.|.:....:|..:.|
Mouse   315 LVWAKLKGFPFWPAKALRDKDGQ-VDARFFGQHDRAWVPVNNCYLMSKEIPFSVKKTKSIFNSA- 377

  Fly   596 CIREVEIHIDHIKRKIGAFNYAPYRTPYDPLEEQQQLEQMMPGVYAAIDRELEPAN------KTP 654
             ::|:|:::::|:||.|.|||:|:||||.|..:.|.|              |:|:|      ||.
Mouse   378 -MQEMEVYVENIRRKFGVFNYSPFRTPYTPNNQYQML--------------LDPSNPSAGTAKTD 427

  Fly   655 LQFLIR----KTADDKLSIVKKTKATESGNE---SDQSPSPTKKLSEVDVVSVTGSGCSDHSNVK 712
            .|..::    .||..|:.:.|...:..:|..   ||...|||...|.|.    |||
Mouse   428 KQEKVKLNFDMTASPKILLSKPLLSGGAGRRISLSDMPRSPTSTNSSVH----TGS--------- 479

  Fly   713 SNNYEVISRSGESLTDSRCKVLLKRKSLAAKIVAESVETSEAVAPKRKHSLSDASFTSESSEHKR 777
                                               .||..    |::|...|..|.:.||.:...
Mouse   480 -----------------------------------DVEQD----PEKKAPSSHFSASEESMDFLD 505

  Fly   778 KSKHARKQHDNQDNQIEEAEKTGQ--------EP--PKSPT--ISKQNENLRDEENVIENAANDT 830
            ||..:           ..:.||||        :|  |::||  ::|.::........|.|...|.
Mouse   506 KSTAS-----------PASTKTGQAGSLSGSPKPFSPQAPTPIMTKPDKTSTSTTGSILNLNLDR 559

  Fly   831 SSASPVSASVVSVVELVRRRQGVTITKIPREQQQTAEDTAAVPIPLPTAPPPKQ-------NIPK 888
            |.|.         ::|....:.|        |||:|        |:|...|.:|       |:.|
Mouse   560 SKAE---------MDLKELSESV--------QQQSA--------PVPLISPKRQIRSRFQLNLDK 599

  Fly   889 GNEAANPKQSDVERQQEQLIKKVIPFIEIKTEVMSEPDDEGI--EEASPANQPQTDQVPLQQETI 951
            ..|:.. .|..:....|.:...|.......:|.....|.|.:  ||..|.|:|:
Mouse   600 TIESCK-AQLGINEISEDVYTAVEHSDSEDSEKSESSDSEYVSDEEQKPKNEPE----------- 652

  Fly   952 TAQPE----SQMPAAAPAPQPKPVDNAPFEEVRIKEEILSEDEMETEQSIVSRRLKSVP------ 1006
              .||    |::...|||.:.||   .|..:|.:|||..|...:..:......:.|:.|
Mouse   653 --DPEDKEGSRVDKEAPAIKRKP---KPTNQVEVKEEAKSNSPVSEKPDPTPAKDKASPEPEKDF 712

  Fly  1007 ---PMPLPMPPPPPLPPREESPATADSVRFVGDTTIQRVSQKQGGKSTDTGGKRKGVQQVPIAGI 1068
               ..|.|.|....|..::|:.:....:....|:..:.|.......|...|.|.|        ..
Mouse   713 VEKAKPSPHPTKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDPSGREGRKNK--------KD 769

  Fly  1069 PQAPSPTHSPLLSTAPSPSASPKPTSTLAVSKPPPPPPPKGKSASHLQFRGKNDRIPTSP----- 1128
            |:.|||....:        ..|.|:||.|.::.||..|...:||:.....|......|:.
Mouse   770 PKVPSPKQDAI--------GKPPPSSTSAGNQSPPETPVLTRSATQAPAAGVTVAAATTSTMSTV 826

  Fly  1129 PATAPPATNTSSLLRSNMVVIPVEQGGSCNAHSPMTIPVPPLRAVSKNTLQNTSTGS-------- 1185
            ..|||....|.|.::....::|.|             .||.::.|..|......|.|
Mouse   827 TVTAPATAVTGSPVKKQRPLLPKE-------------TVPAVQRVVWNASSKFQTSSQKWHMQKI 878

  Fly  1186 ----------TSSCVPSSVSMPPPLAGL------SIPPV------ATPTSQEESITNSGQPVGLL 1228
                      ..|...|....|....|.      ::..|      .:|::...::..|.||..|:
Mouse   879 QRQQQQQQQQQQSQQQSQQQQPQSSQGTRYQTRQAVKAVQQKEVTQSPSTSTITLVTSTQPAALV 943

  Fly  1229 ASALNGTANDVLSSDSIPNDPITPGLATALSEMLLHTGVPKLIARPRGALRSDGSQIYPSQAGPV 1293
            :|  :|:|:.:.|:       |...|..|.:...:...:.|..::...|::...::||
Mouse   944 SS--SGSASTLASA-------INADLPIATASADVAADIAKYTSKMMDAIKGTMTEIY------- 992

  Fly  1294 SQKLKENAHKITDYFISVIEDTLSDMATGDQSVLQARIAGLSLENERLKQHYDRQINDLHRTSEL 1358
                                :.||...||...   |.|..|.:|.|:|:..:.:::.::....||
Mouse   993 --------------------NDLSKNTTGSTI---AEIRRLRIEIEKLQWLHQQELAEMKHNLEL 1034

  Fly  1359 MISEMRKTLEQEHKRVISELRQQNAIELMRAVEEAKRKQWCANCMREAQLYCCWNTSYCDYPCQQ 1423
            .::|||::||||..|:|:|:::|..:|..:||:|.|:|||||||.:||..|||||||||||||||
Mouse  1035 TMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQ 1099

  Fly  1424 LHWPGHSATCGQSVPPTIPVPPSVPTPIIEPGRAKAKVATPTATPSITNPSPSSQIMRTVAACPS 1488
            .|||.|..:|.||.  |.|           ...|.|:.:|.|...|....|.::|      :.||
Mouse  1100 AHWPEHMKSCTQSA--TAP-----------QQEADAEASTETGNKSSQGNSSNTQ------SAPS 1145

  Fly  1489 APPSANASSSKKWPPMMTLMNQSNQEAMLKLPATTYLRPVVSTTMTAPVTAPQPANNNSTNVIMA 1553
            .|  |:|...|:                                  ||....:.::|::.::..:
Mouse  1146 EP--ASAPKEKE----------------------------------APAEKSKDSSNSTLDLSGS 1174

  Fly  1554 PTPPP----GNNLATIISAQRNPPNYNA----KHPNPAMPVQRFNIPLPITVNSNAPFMMAEQHQ 1610
            ...|.    |:|.:::.......|.|..    ..|:|..|.|:::      ..|:...:.:...:
Mouse  1175 RETPSSMLLGSNQSSVSKRCDKQPAYTPTTTDHQPHPNYPAQKYH------SRSSKAGLWSSSEE 1233

  Fly  1611 KQVPKATGRSGKNNSR 1626
            |:....:..||..:::
Mouse  1234 KRASSRSEHSGGTSTK 1249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zmynd8	NP_651881.2	PHD_PRKCBP1	345..386	CDD:277013	14/40 (35%)
		Bromo_RACK7	403..501	CDD:99940	33/98 (34%)
		PWWP_PRKCBP1	523..616	CDD:438988	42/92 (46%)
		zf-MYND	1399..1433	CDD:460312	25/33 (76%)
		PHA03247	<1427..1592	CDD:223021	32/172 (19%)
Zmynd8	XP_006499441.1	TNG2	<30..168	CDD:227367	33/131 (25%)
		PHD_PRKCBP1	125..165	CDD:277013	13/45 (29%)
		Bromo_RACK7	186..284	CDD:99940	37/98 (38%)
		PWWP_PRKCBP1	307..397	CDD:438988	38/89 (43%)
		DUF3544	457..657	CDD:463452	41/218 (19%)
		PTZ00449	<645..800	CDD:185628	36/176 (20%)
		AtpF	<1004..>1071	CDD:440475	8/66 (12%)
		zf-MYND	1075..1109	CDD:460312	10/33 (30%)