DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rod and kntc1

DIOPT Version :9

Sequence 1:NP_476705.1 Gene:rod / 43719 FlyBaseID:FBgn0003268 Length:2089 Species:Drosophila melanogaster
Sequence 2:XP_009300257.2 Gene:kntc1 / 497376 ZFINID:ZDB-GENE-050208-92 Length:2241 Species:Danio rerio


Alignment Length:2393 Identity:482/2393 - (20%)
Similarity:901/2393 - (37%) Gaps:570/2393 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MWSNFEA------------SSLEDETISNIFSSRGIFQISSEEEVNKYPDVMASVQCGKMVIGID 53
            ||:|.|.            :.:|.|:.:.::....:.:|||.|:|...|:|.||......:|.:|
Zfish    10 MWNNVELLLNEDTNTVRLYNDVEQESGNALYQVDNLVKISSSEKVVSKPNVYASSTPNCCIIVVD 74

  Fly    54 KSLLLLEDELVAKCSFLAFGAAIEAIAISSSGNLIVCGLSDGEVHGVFIKGLLLFSVAVNLEDVS 118
            .:::|.:.........|.|.:.::|:.:...|..::.|..:|.:|.::|. |....:..||....
Zfish    75 TAVVLFDPGFQTVLIHLYFDSVVDAVTVCPQGQFLLVGERNGSLHIIYIP-LKKTVLTKNLPQQK 138

  Fly   119 LTGG--TFRS--IHQL-----DQRFYFTCKNGSIYSLSDIDETCLETLGNMSLN------ENETI 168
            .:.|  ||:|  :|:.     |...:|..|:|.::            :.|::|.      ||..:
Zfish   139 SSCGETTFKSLILHEKPGSKGDYDLFFVIKDGFLH------------VSNVALGKIQRAIENMDL 191

  Fly   169 ACEKALLEDVTIQRLS------KGRSSCSVDCAVLLKRLLTGNISAENNQDDLEAQPGLVITGDQ 227
            .....:.||:.:...|      .|..|.|:.|......||.|            |....|::  .
Zfish   192 VVLNKIQEDILMNFFSTKEIHEDGCISASLVCFGSTSHLLIG------------ADGANVLS--L 242

  Fly   228 STMNFRNAANDVTRINLPAQYGSLKQIFNLEHYIIALTDSGHLVEICPYTRTVYMCQTTQQKNLL 292
            .:|.....:..:|::...:....:|::..:::.:..|.:.|.|..:..::..:..|...|   .:
Zfish   243 WSMGLHQTSMSLTKLLDSSLMSEVKKVQVVDNLMYVLNNEGMLSMLDIHSFVMLCCWPDQ---YI 304

  Fly   293 IEDLLVMECS-------EDN---IELLVLTKSTAEGRFIKIVEYPTLNVKNEVEVPDHAWLVRQP 347
            ::.||:.:.:       :||   |..||:..:....|.:.:....::.|...:||...:||:::.
Zfish   305 VDFLLISDGNSSSITQQDDNTLKIMTLVVEGNKDHSRKLVVQSLSSMEVFYSLEVSSESWLIQKG 369

  Fly   348 KCAVNLYYLAAKEVNQSSIP----SVVEMMLVSETDPSDRFKKLICKGRLEEAEEFGKQFELCLQ 408
            .....:|.|.....|..|.|    |.|.:...:|..|.:|..||:.|.:.||||:|.|.|.|.::
Zfish   370 ISMDTIYLLEGVLANTKSSPEDPVSTVVIRCFTEALPENRLNKLLYKHKFEEAEKFAKTFGLDVE 434

  Fly   409 PIYEAKAKRILVELCNSNSQNVDTKFQDLLQLLSQVESKAFIKSHRMINLNSRHILERY------ 467
            .:|:.|...:|.:|.:::..:...::.:|:|     |:|.     .::.:.....:.:|      
Zfish   435 LVYKVKLNVVLEKLISASGNDQTIEWPELIQ-----EAKT-----NLMKIMDEQFVVQYCLSASW 489

  Fly   468 --LHEVKKRLTFEDDEEDMLEIDEQLHRLKTLAIIDPYECNT----DWQKFIYDNNLVRMVKSLF 526
              |...::.|.:..:.....:|...|.:|.|.:.:  |..|.    .|.:|:...:.::.:.:|.
Zfish   490 PTLSIAEEMLNYTLNRFPCCQIQTALAKLATFSSM--YGPNNFDGIKWIEFLNSTDYLKDILALL 552

  Fly   527 NT-DMPTACLIWRRHSSSILPLLNEDELRTLLGFIPSNTKPFNVVQWLR-QFIPMVSNTHPSIMP 589
            .. ::..|..:|.||........:|.....||..|.|:....:::.|.: ..:|.|....|....
Zfish   553 KEGNVNGAQYLWLRHEGEFASEFDEACFHALLSSISSDIPSQDLIPWFKGVVVPFVWRVLPKGQK 617

  Fly   590 FITDWSIEMTRNLQYS--PHWPDIGL-----------------EFCTKILDIFEEIQFTYSDVRR 635
            .|..|.....|||:.:  ..||..||                 |.|..     ||::        
Zfish   618 IIARWLEHRARNLELTEKSDWPQNGLLLAELGLPSLWRSMGLAEICGA-----EEVE-------- 669

  Fly   636 QQERNVGKLRDLVNALQDLSVLKTNYNMGFTLDNYMQDSIDATALSILQHVQLDKL-QRLVKNFM 699
                   .||.||..|:.|..|...||...:|.:|.:.|..:.|..:|..||..:| ..:|::.:
Zfish   670 -------SLRSLVANLRQLCDLYIKYNCHLSLSDYERGSTRSMAFLMLDKVQAPELIPAVVESSV 727

  Fly   700 YPIFQEKGRQPLDVIKQYISQLV---ASRLSS--SSWLDRAMACIELLHNEDSRLECALSVLQNA 759
            .|...|.|......:..||..|:   :|:::|  :.|..:|:|.:..:.:.:..::..:.::..|
Zfish   728 EPYALENGLDLDQTLLDYIKDLLDCCSSQITSLFTEWEAKAVAVLHCMKDTNKVMDAVIEIMYKA 792

  Fly   760 PVPWPDTLAPLIRLR-ASTHPLAVKINAEYEIQVIKIMKVKYGWP--ADSSDINLELFMMRIVKL 821
            .|||.||:..|::|. ...||....:...|.:..||.:...||..  |.|:..::.:.:..|:|.
Zfish   793 VVPWSDTIEKLVQLHLEKEHPKQELLREGYRLMEIKKLLRCYGIRSLALSNSRDIMMLVRYILKQ 857

  Fly   822 NLPDMLDDISALTKAAPELSTSANFNCCYQMARRGQVEMAYEFFKKLN----------------- 869
            :||..|:|...|.:|........:...|.|:.:|.:.|......|.|.                 
Zfish   858 DLPTSLEDSLKLIEAYKLNPAEFHHLHCIQLIQRNKREKCTTLLKSLPHSEAIFVIERMACWARL 922

  Fly   870 --------GEKNSKSAKEVVEIMANILENSSSASFESDIKVQEHLNVLELFKLFLPHVESVYE-- 924
                    .|:..|....:.:||...|:...|...:...|..|..|.|::|.. :.|::..::  
Zfish   923 ELQDKQHISEEQKKLQMLISQIMVEALKYLQSIQTDDAFKKTECENNLKMFTA-IAHLQEDFDIF 986

  Fly   925 ---RRY--LVIKHRFRLRKFGILLSCSSELIPLHRRHCLLDEAIERIIER-----AQATLNVSAF 979
               ..|  .|::|:|           :.:||..:..    .:|..|..::     :.:.||.||.
Zfish   987 LTPEEYDDPVVRHKF-----------NQQLITAYEN----TQAWRRSGKQHPDKVSDSNLNGSAA 1036

  Fly   980 IASEISELCTALGLPKVFGLHRICQRIGCL--PLSCALAYHVVSFVDCVPANAGEFVNLALELLV 1042
            :|::......:|....  ||||:.:::...  .|...||...:        :||. |..||::|.
Zfish  1037 VANDPDGKTKSLSTEA--GLHRLARQLQKTEQELWADLALRAL--------DAGN-VEKALQILS 1090

  Fly  1043 QQIESAKGKNQ-----ETASSL-QLINENDPLSFYLAYELLTSALLH----------ESSRRHDL 1091
            :..:.....:.     .||..| |::.||.|:  .|..:....|::|          .|....|.
Zfish  1091 ELYQHHSNCSTGRVLFSTAQRLCQMLEENVPM--VLPEKTNLPAVIHRLACQAITVCHSDLLLDC 1153

  Fly  1092 VELIKYIRVA--------VIHYPLDAIKSHYDGKEQAVNE---HICRALDGISVALGETTINFSC 1145
            :||.|..|.|        :..:...|.:|...|:|.|..|   |.....|||             
Zfish  1154 LELCKSTRTAADVYRQCQIEDFGFFAKESSMSGEEDAYAESHFHDVFNEDGI------------- 1205

  Fly  1146 ALNGSFDVKTLTVPTTTKKRYSVSMFDEVEVQPIQQQPQKKSVGGRMAIVKFLARTLL------- 1203
                                    :.|.|.|.|:|.:               :.|.||       
Zfish  1206 ------------------------VLDPVSVLPLQYK---------------ITRNLLPLSESRL 1231

  Fly  1204 -------LMVIETEPNNSLLMQVRNELPENTKADVESACADFFLSLEHLTKVKEHDAWYVMSQY- 1260
                   |....|:.:..|:..:.|  |..:...:...|:...|::..|           |..| 
Zfish  1232 FPFDCSCLSYCSTKEDAELVGPLLN--PMASMLQMLQECSQLELAVRLL-----------MESYG 1283

  Fly  1261 --LLDFQKQN---CRTKRIINEGFITLQ---LRRIFRNAMGSKDVNFIELFTML----VVDSE-A 1312
              ||.|...|   ..:||:.:...:...   |.:|.:..:.|..|..:.|...:    ||||: |
Zfish  1284 SILLHFVSNNMDISLSKRLQSNNRMARDKQTLDKIEKTVLSSVSVVVVSLLQKVLNWRVVDSDLA 1348

  Fly  1313 LALLEKLSVEVKTDL---------QKINFLTLSAMYHEHIEDLDSVHMIRTKRLKLFYYLEFCQQ 1368
            :.|...||.....|:         |..:.:.:.||...|:                    .|..:
Zfish  1349 IGLCTILSKAAVIDILWKIINSAWQNYDKIKVVAMVGAHV--------------------SFLYK 1393

  Fly  1369 DHRIKGKFNADMDNIE----------------------------DLLKEFHNKQLDVQLLERMSK 1405
            |...:|||.:.:.:.|                            .|:|   ||.:...::.....
Zfish  1394 DEEERGKFVSVITDAEWGVQLGRLGVSIQSVFRQCTETKRNLIPTLVK---NKNITPDIILHYCS 1455

  Fly  1406 DFGFDYQKILITQILSILSAQELRFEVKRDTFGDEELVM-----LSSAQEMRDMCQPYINEINNV 1465
            .||.|....:...|.::|..::..:|::.:. ||.|..:     |....:|.:.....|.::.:.
Zfish  1456 TFGLDSYSAINLYITTLLLQEDRWYEMEIEE-GDAESSLRIQESLRGKDDMLESALQIIPQLGST 1519

  Fly  1466 ELFTSKLKHFIEDINIYFYELYMCVINILMYFDSAPKEMEIWMNILHFLRHKMITRRRNRPGQVE 1530
            :.....|...:..:|.|.||....|:..:...|.:...:.:. .::..|:|....||.:.|..:|
Zfish  1520 KDLVISLNTALTKLNPYNYEWIERVLKTIQMADESTTLIPLG-QMVGLLQHLKSHRRISPPTDLE 1583

  Fly  1531 TDTWLKSQRENGVMP-KISRYRLPF---------------KPIVEQPLKDIL----DSELNVDNC 1575
            :...|    ||.:.| .::..||||               ..:.|:.|..:|    ..::|:|..
Zfish  1584 SSYLL----ENSLEPTALANTRLPFHLLFQSSHAFWKIVSPELSEETLPTLLLICKLMKVNLDKL 1644

  Fly  1576 ----------QSWFPLIQMYTA----LKGSKDSSQNCDYFCMSA--VKN----SISEYKSKNDSE 1620
                      :|..||:...|.    |..||:.....|.....|  ::|    :.:.:|...|..
Zfish  1645 YVLAVNHVFKKSLLPLLMDQTKKIQHLGSSKELCSVTDSVFQHALCIQNLELAAATVHKIAQDLP 1709

  Fly  1621 SWSLHPTNNAFLQSILRLVEKVNNPNKAFLILYFVSNYARDGADQVEASYECWKFVKEKGHLITD 1685
            :.::   ...||:..|.||.|:..                  :|.:|.|      ::.:|..:  
Zfish  1710 AGAV---KTDFLKFSLDLVHKLLK------------------SDTLEES------LQARGEAL-- 1745

  Fly  1686 PKSREQVAKVKRRYPIQKTQHLLYVYGLTDEKLLRQVENPTELIQALYHHELILKSSK------- 1743
                  ::|::.:|....|::.|....|...:||:....|..||.||:.|..:|...|       
Zfish  1746 ------ISKLQLQYQRSATENALLSSQLGSPELLKLTGLPGRLIVALFEHSSVLDRMKNPAGQTY 1804

  Fly  1744 VDINALVAEIAKLHDLCLATIQYRLLQKWLALTMESAGDGTILEETFMEEQNWPEQANGAESSNS 1808
            .||:::.:|||.::.:.|..|:..||:|||..|.:|.|                      :..|.
Zfish  1805 PDIHSVASEIASINSVDLLKIRNILLEKWLCQTGQSNG----------------------KDINH 1847

  Fly  1809 QDASENVN------RAFYILSSWPKAEAVKFLVGLIFK-----GGS---VNTSTQLQMYECYSKL 1859
            ||...:||      |..|:|...|...:.:.|..::..     |||   :....:.:...|.:.|
Zfish  1848 QDNVTDVNDDPDLMRVVYLLQMHPMDISARLLSPVLTSQTWPLGGSGLRLTFEHRSRALLCLTHL 1912

  Fly  1860 NDGS--NSFTNTISQRQFISIKC---VHELKALGYKSNLEKFSDDHCNKIDILKMIWQRNAQNPL 1919
            .|.:  .:.:|..|.:....:||   :.:::||.....|:.|...  .|..::|.:|:.:...|.
Zfish  1913 TDAATLETLSNQPSSKIKYYLKCYMYLAQMEALNIPYTLDMFISS--PKEGMIKGLWKNHNNEPQ 1975

  Fly  1920 SLEVMANICLGFDIHLPQIWNGILKRMVMFHMVRELNALLDVLSCRPHLLHLDGLAQAWDYVLCH 1984
            ::.::|::||.:.::..|:||.:|::::.|:|...|..:|:.|...|.||....|::.|..|:..
Zfish  1976 AVRLVADLCLEYGVYDLQLWNSVLQKLISFNMTSYLQKVLEALIAVPSLLEGQSLSRIWRSVIQA 2040

  Fly  1985 PLQNAVELRSFKQEEVLHKTLLRLQGCPVVHALNLL----QFAQL--------------CIVVHR 2031
            |...|....|.:|..|::||.:.|..||.:..|:|:    :|:|.              |:....
Zfish  2041 PFLTASLPLSPQQHMVMYKTFVLLLKCPFLFTLDLVAIAKRFSQFSLQAFSLGTLLLIPCLKKKE 2105

  Fly  2032 PHMAASLLSFC-------QSSEQR---------QKIKKMIHSHPVENLRQQIL 2068
            |.:.:.||| |       |:.|..         .:|::.:.:...:|.:.|.|
Zfish  2106 PQIQSFLLS-CNPTLILDQTEESMATGELAGIPSQIRETVFAFLCQNGKSQTL 2157

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rodNP_476705.1 Rod_C 1544..2082 CDD:287465 134/625 (21%)
kntc1XP_009300257.2 Rod_C 1597..2144 CDD:313674 130/606 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170596375
Domainoid 1 1.000 156 1.000 Domainoid score I4167
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 264 1.000 Inparanoid score I3056
OMA 1 1.010 - - QHG52014
OrthoDB 1 1.010 - - D122381at2759
OrthoFinder 1 1.000 - - FOG0007375
OrthoInspector 1 1.000 - - oto39117
orthoMCL 1 0.900 - - OOG6_106565
Panther 1 1.100 - - LDO PTHR15688
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X6266
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1211.910

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