DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment chp and atk

DIOPT Version :10

Sequence 1:NP_001263137.1 Gene:chp / 43690 FlyBaseID:FBgn0267435 Length:1338 Species:Drosophila melanogaster
Sequence 2:NP_649228.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster


Alignment Length:1365 Identity:325/1365 - (23%)
Similarity:543/1365 - (39%) Gaps:297/1365 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LTITLMIMIWMSLARASMFDREMEETHYPPCTYNVMCTCSKSSTDLGIVHCKNVPFP-------A 71
            |.|.|::.|.::|.||.         ..||....:.|.||....::.| .|.:...|       |
  Fly     4 LPIFLLLCIGINLIRAE---------SCPPSQAILPCRCSLRGKEIQI-WCSHSNLPQIMDGLKA 58

  Fly    72 LPRMVNQSKVFMLHMENTGLREIEPYFLQSTGMYRLKISGNHLTEIPDDAFTGLERSLWELILPQ 136
            :.|.: :.::..|.:||..|..:...|..|..:.||.:..|.:..:.:.....||..|.|:.:.:
  Fly    59 VERNI-KGRIDELVLENNQLPALPGRFFGSLQIVRLMLRHNSIERVSNGWLNELENGLVEIFVVE 122

  Fly   137 NDLVEIPSKSLRHLQKLRHLDLGYNHITHIQHDSFRGLEDSLQTLILRENCISQLMSHSFSGLLI 201
            ..|..||::||..:..:..:.:....:.|:  ..|.||. ||..|.::...:.:|.||.|..|..
  Fly   123 PQLRSIPAESLNGMINMLAITIQSEELKHL--PDFSGLL-SLTYLSVQTGALQELPSHLFRHLPK 184

  Fly   202 LETLDLS-GNNLFEIDPNVFVDGMPRLTRLLLTDNILSEIPYDALGPLKSLRTLDISHNVIWSLS 265
            |:.:.:: |:.|..::..:| ||:..|..|.|:.|.|:.|...||..|.:|.:|.:|||.|..:.
  Fly   185 LQHIHITGGSGLTRLEAGLF-DGLISLKNLDLSHNGLNWIHLRALSRLPNLVSLKLSHNQISDVG 248

  Fly   266 --GNETYEIKASTKLNLDNLHLEYNHIEVLPPNSFKYFDTVNRTFFDGNPIHTLREDAF-KPARI 327
              |....:::...||.|||     |.|.|:...||.....::....:.|.|..|:..|| :..::
  Fly   249 MVGRIVKDLEHLKKLRLDN-----NLITVIEDGSFVDLPNLSELHLNDNRITELQYGAFLRTPQL 308

  Fly   328 REIYMRYCGLTNISPVAFDSLVNS------------------------------LQILDLSGNNL 362
            :.||::...:..|.|   :||:.:                              |:.||:|||.|
  Fly   309 KTIYLQNNLIRRIHP---ESLLQASGSGVEAVHMYNNEIGHVEALRALLDALPRLRYLDMSGNLL 370

  Fly   363 TKL-------------------HHKLFNN-----FDVLRVISMRDNKIKIQKPTETFNAVHYTLL 403
            ::|                   |.:|...     ...||.:.||:|.:....|...:|..  .|.
  Fly   371 SELPYGALRGHGTLEQLHLNHNHLRLIERDALMAMPALRELRMRNNSLSSDLPLPFWNLP--GLK 433

  Fly   404 KLDLSGDRNDPTNLQTLRKMRNMRSLSISRLGSSSVGPEDFKDFGVELEDLQITRASLSGIQSHA 468
            .|||:.::....:.|.|..:.::|.|.:|..|...:.|..|:...: ||.|.|:...|:.|.|..
  Fly   434 GLDLAQNQFARVDSQLLAGLPSLRRLDLSENGLIELAPNSFRHNPL-LETLNISSNELTKIHSST 497

  Fly   469 FKHVRGLKRLDFSENGISS--------IENDAFHEIGHSLISLKMSHGYSGSALPAEPLRHLTSL 525
            ..|:..|..:|.|.|.:.|        :|.          ||||   |...::|||...:.|.  
  Fly   498 LIHLERLFEVDASYNQLKSVIAGLPRIVER----------ISLK---GNQITSLPAAASKDLQ-- 547

  Fly   526 QELDFSNNHISSMSDTSFHFLKNLRLLELHDNRIEQVLKGTFQGDIHSKLEEISLRFNHLTSISQ 590
                                |.|||:|:|..|||||:.:..|||.:  :|..:||..|.|..:..
  Fly   548 --------------------LPNLRMLDLSQNRIEQLPRHGFQGAM--ELRVLSLAQNELRQLKD 590

  Fly   591 HTFFDLEALRKLHLDDNKIDKIERRAFMNLDELEYLSLRGNKINNLADESFQNLPKLEILDMAFN 655
            .:|..::.|..|||.:|::.:.:.||.:.|.||..|:|:.||:..:.|..|.|..:||.||::.|
  Fly   591 TSFIGIQRLELLHLQENQLGEADERALLPLAELRNLNLQSNKLEAITDNFFSNNSRLEQLDLSRN 655

  Fly   656 QLPNFNFDYFDQVGTLSNLNVNVSHNQIRQLMYNSSWSGRNEHGGMYHSNIKILDLSHNNISIIH 720
            .:.:.:...||...:|..|  ::|.|.:..:....        |.:  :|::.:|||:|.||.|.
  Fly   656 LIRSISPTAFDTQRSLEYL--DLSGNALLDISVGL--------GNL--NNLRDIDLSYNQISRIQ 708

  Fly   721 P----GYFRPAEISLTHLHLGYNSLMNTTRDVFGNMPHLQWLDLSYNWIHELDFDAFKNTKQLQL 781
            .    |:....||.|::     |.::...:..|.|:|.||:||||.|.|..::..|.|...:||.
  Fly   709 SDVIGGWRNVVEIRLSN-----NLIVELQQGTFRNLPKLQYLDLSSNEIRNVEPGALKGLDELQE 768

  Fly   782 VFFGHNYLSDIPQDIFKPVQGLRIVDFSHNHLRGLPDNLFYN-GGMEKLDVSHNMMLKIPSSSLS 845
            .....|.|.::...:|:.:..|....|.:|.||.:....|:| ..:..|::|:|....:.:..|.
  Fly   769 FVLADNKLVELKDHVFEELPSLLASHFQYNKLRYISPESFHNANSLVFLNLSNNHFRNMENIGLR 833

  Fly   846 SLAALTLCELHLSNNFISTIHSMDLSNKFRSLRY---LDISYNYLLRIDDAVFATMPKLAVLDLS 907
            |:..|.:  |.||.|.:..:.:|.|    ::|.:   |.:..|.:.||..:.|.|||:|.||.:.
  Fly   834 SMRNLEV--LDLSTNGVKLVSTMPL----KALNWLVELKMDNNQICRIQGSPFETMPRLRVLSMR 892

  Fly   908 HNRDLKVMDKSFMGLENSLIKLGLENISLSTVPEIR--LKYLREFRLGYNELPSIPQELAHNMSN 970
            :|:...:.:::|..:..::..|.::...:....|::  ..:|:|....|   |....:....:.:
  Fly   893 NNQLRSIKERTFRNVRGNIAILDVDGNPIDCNCEMQWLSVWLQETNFPY---PGPKCQDGRLLRS 954

  Fly   971 LRM-------LDLSNNDLTNVPLMTQALPHLRRLMLSGNPITSLNNNSFDGVNEDLEMLDISNFR 1028
            .||       .|:..|:.|:                 ||.:..||.:.      |:...|:.:..
  Fly   955 ARMERSLCVGADIYGNERTD-----------------GNQLPLLNEHG------DVFQRDLPDDF 996

  Fly  1029 LHYFEYGCLDSLPHLRSLKLTAYSHLEHFNIPHLLRHHYNIRQLWIEAPQPFTRIVKKGSGPTQE 1093
            ....|.|....||..|.|    ....|:|         |:......|||..          ....
  Fly   997 NDECEAGEGTRLPGDRPL----VGESEYF---------YDQYVDATEAPDT----------THSA 1038

  Fly  1094 MQTLQLGNPTDLQREMEGHLPSKLTNITFSGPQFTNLNERILR----------GMRSPYLYM--Q 1146
            :.|.|...||          |:..:||        :||..||.          |..||:.:.  .
  Fly  1039 ISTSQRPKPT----------PTINSNI--------DLNNTILHTKYFNRKPQPGSGSPFTFFGYP 1085

  Fly  1147 LFNTSLQALPPNFFKYMGRVRNISLDIR-----YHNRNLKKIPNPNTGAVPYLPNSV----FLTD 1202
            |.:.||    ..||.:..|.|....|..     .|......:|:.......|.|||.    :|.|
  Fly  1086 LPSVSL----GRFFGFGDRGRKQRTDSNDDMPATHRMAHISLPSGRGKTRMYQPNSAEFEKYLKD 1146

  Fly  1203 LKMSHTDLNCDCDLGWVEFWQRKRRQYICSSQT----------------WTDTVFRTFMNSPCQV 1251
             :.....||.            .|.:|:.:..|                .|..||||....|..:
  Fly  1147 -QQKQEKLNI------------ARNRYVDTDSTTSSMEDALSNESGSAATTVGVFRTTFREPSSI 1198

  Fly  1252  1251
              Fly  1199  1198

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
chpNP_001263137.1 LRR <84..320 CDD:443914 65/238 (27%)
leucine-rich repeat 84..103 CDD:275380 6/18 (33%)
leucine-rich repeat 104..128 CDD:275380 5/23 (22%)
leucine-rich repeat 129..152 CDD:275380 7/22 (32%)
leucine-rich repeat 153..177 CDD:275380 4/23 (17%)
leucine-rich repeat 178..201 CDD:275380 7/22 (32%)
leucine-rich repeat 202..226 CDD:275380 6/24 (25%)
leucine-rich repeat 227..250 CDD:275380 9/22 (41%)
leucine-rich repeat 251..279 CDD:275380 8/29 (28%)
leucine-rich repeat 280..326 CDD:275380 13/46 (28%)
leucine-rich repeat 327..348 CDD:275380 4/20 (20%)
leucine-rich repeat 352..375 CDD:275380 10/46 (22%)
PPP1R42 355..564 CDD:455733 62/240 (26%)
leucine-rich repeat 376..401 CDD:275380 7/24 (29%)
leucine-rich repeat 426..450 CDD:275378 6/23 (26%)
leucine-rich repeat 451..474 CDD:275380 8/22 (36%)
LRR_8 473..559 CDD:404697 22/93 (24%)
leucine-rich repeat 475..524 CDD:275380 15/56 (27%)
leucine-rich repeat 500..519 CDD:275380 8/18 (44%)
leucine-rich repeat 525..548 CDD:275380 1/22 (5%)
LRR <540..>834 CDD:443914 89/298 (30%)
leucine-rich repeat 549..574 CDD:275380 12/24 (50%)
leucine-rich repeat 575..598 CDD:275380 6/22 (27%)
leucine-rich repeat 599..622 CDD:275380 8/22 (36%)
leucine-rich repeat 623..646 CDD:275380 8/22 (36%)
leucine-rich repeat 647..730 CDD:275380 22/86 (26%)
leucine-rich repeat 648..673 CDD:275380 7/24 (29%)
leucine-rich repeat 674..705 CDD:275380 4/30 (13%)
LRR <730..1081 CDD:443914 82/363 (23%)
leucine-rich repeat 731..754 CDD:275380 4/22 (18%)
leucine-rich repeat 755..778 CDD:275380 10/22 (45%)
leucine-rich repeat 779..802 CDD:275380 5/22 (23%)
leucine-rich repeat 803..823 CDD:275380 6/19 (32%)
leucine-rich repeat 852..876 CDD:275380 6/23 (26%)
leucine-rich repeat 877..900 CDD:275380 8/25 (32%)
leucine-rich repeat 901..925 CDD:275380 5/23 (22%)
leucine-rich repeat 926..946 CDD:275380 2/21 (10%)
leucine-rich repeat 947..970 CDD:275380 4/22 (18%)
leucine-rich repeat 971..993 CDD:275380 5/28 (18%)
leucine-rich repeat 994..1014 CDD:275380 4/19 (21%)
leucine-rich repeat 1019..1042 CDD:275380 4/22 (18%)
atkNP_649228.1 leucine-rich repeat 886..906 CDD:275380 5/19 (26%)
PCC 891..>936 CDD:188093 5/44 (11%)
leucine-rich repeat 69..89 CDD:275380 6/19 (32%)
leucine-rich repeat 90..113 CDD:275380 4/22 (18%)
LRR 93..530 CDD:443914 110/461 (24%)
leucine-rich repeat 115..138 CDD:275380 7/22 (32%)
leucine-rich repeat 139..160 CDD:275380 4/23 (17%)
leucine-rich repeat 161..184 CDD:275380 7/22 (32%)
leucine-rich repeat 185..209 CDD:275380 6/24 (25%)
leucine-rich repeat 210..233 CDD:275380 9/22 (41%)
leucine-rich repeat 234..259 CDD:275380 7/24 (29%)
leucine-rich repeat 260..283 CDD:275380 10/27 (37%)
leucine-rich repeat 284..307 CDD:275380 5/22 (23%)
leucine-rich repeat 308..359 CDD:275380 6/53 (11%)
leucine-rich repeat 334..348 CDD:275378 0/13 (0%)
PLN00113 359..>824 CDD:215061 142/521 (27%)
leucine-rich repeat 360..383 CDD:275380 8/22 (36%)
leucine-rich repeat 384..407 CDD:275380 2/22 (9%)
leucine-rich repeat 408..431 CDD:275380 7/24 (29%)
leucine-rich repeat 432..455 CDD:275380 6/22 (27%)
leucine-rich repeat 456..476 CDD:275380 6/19 (32%)
leucine-rich repeat 480..501 CDD:275380 7/20 (35%)
leucine-rich repeat 505..517 CDD:275378 3/11 (27%)
leucine-rich repeat 525..550 CDD:275380 11/59 (19%)
leucine-rich repeat 551..574 CDD:275380 12/24 (50%)
leucine-rich repeat 575..598 CDD:275380 6/22 (27%)
leucine-rich repeat 599..622 CDD:275380 8/22 (36%)
leucine-rich repeat 623..646 CDD:275380 8/22 (36%)
leucine-rich repeat 647..670 CDD:275380 7/22 (32%)
leucine-rich repeat 671..693 CDD:275380 5/33 (15%)
leucine-rich repeat 694..717 CDD:275380 8/22 (36%)
leucine-rich repeat 718..741 CDD:275380 6/27 (22%)
leucine-rich repeat 742..763 CDD:275380 10/20 (50%)
leucine-rich repeat 766..789 CDD:275380 5/22 (23%)
leucine-rich repeat 790..813 CDD:275380 7/22 (32%)
leucine-rich repeat 814..835 CDD:275380 4/20 (20%)
leucine-rich repeat 838..861 CDD:275380 8/28 (29%)
leucine-rich repeat 862..885 CDD:275380 7/22 (32%)

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