Protein Alignment chp and LOC1270408

DIOPT Version :10

• Sequence 1: NP_001263137.1
• Gene: chp / 43690
• FlyBaseID: FBgn0267435
• Length: 1338
• Species: Drosophila melanogaster
• Sequence 2: XP_061508553.1
• Gene: LOC1270408 / 1270408
• VectorBaseID: AGAMI1_008706
• Length: 1403
• Species: Anopheles gambiae
• Alignment Length: 1344
• Identity: 315/1344 - (23%)
• Similarity: 543/1344 - (40%)
• Gaps: 287/1344 - (21%)

  Fly    15 TITLMIMIWMSLARASMFDREMEETHYPPCT-----YNVMCTC------SKSSTDLGIVHCK--- 65
            ||...:::.::.|.||:      ...:.|||     ..:.|.|      :.|......|:|.
Mosquito     4 TIDARLLLLLACALASV------SCAWRPCTDLDALLKIPCRCNIETAGNNSQYVFVNVNCDRTT 62

  Fly    66 -NVPFP----------------ALPRM-VNQSKVFMLHMENTGLREI------------------ 94
             ..|||                |||.: :..:.|..|...|..||.|
Mosquito    63 LTAPFPSGIPIISFSQRNSGHQALPDLSILNAPVRKLDFSNNALRSIGTKALFGSLAEYLTELRL 127

  Fly    95 ---------EPYF-------LQSTGMYRLKISGNHLTEIPDDAFTGLERSLWELILPQNDLVEIP 143
                     .|.|       |||..:  |.:|||.:..:.:..|.| .|.|.||.|.||.:..:|
Mosquito   128 ANNLLGDSLNPIFSTDVLQALQSLKV--LDLSGNRIIALEESIFDG-NRRLVELYLDQNKIATVP 189

  Fly   144 SKSLRHLQKLRHLDLGYNHITHIQHDSFRGLEDSLQTLILRENCISQLMSHSFSGLLILETLDLS 208
            ..:::.|..|:.|.|..|.|..::.|:| ...:.|:.|.||.|.|..|.|.:|:.|..::.:.|:
Mosquito   190 VAAVKELTSLKLLSLRSNRIESLEPDAF-NFANKLERLDLRNNRIRTLKSKAFANLASMKEVLLA 253

  Fly   209 GNNLFEIDPNVFVDGMPRLTRLLLTDNILSEIPYDALGPLKSLRTLDISHNVIWSLSGNETYEIK 273
            ||.|..||..... ||..|.:|.|:||:|||.|.:|||.:.||:.|:||.|.|..|..|...::|
Mosquito   254 GNQLSHIDERALA-GMDVLQKLDLSDNLLSEFPSEALGSVVSLKVLNISLNNIGKLESNHLAQMK 317

  Fly   274 ASTKLNLDNLHLEYNHIEVLPPNSF------KYFDTVNRTFFDGNPIHTLREDAFKPARIREIYM 332
                 :|..|.:..|.|..:.|.:|      ||.|      ...|.:.|:.:|||:
Mosquito   318 -----SLQILDISRNTIATILPGTFREQLLLKYLD------LSLNSLRTIEDDAFE--------- 362

  Fly   333 RYCGLTNISPVAFDSLVNSLQILDLSGNNLTKLHHKLFNNF-DVLRVISMRDNKIKIQKPTETFN 396
               ||.|:..:    ::....||.:.|:.|.:| .||.|.: |..||.::..:.:|..:|..
Mosquito   363 ---GLDNLQTL----ILRDNNILFIPGSALGRL-PKLSNLYLDFNRVAALSSSILKSIQPEN--- 416

  Fly   397 AVHYTLLK----LDLSGDRNDPTNLQTLRKMRNMRSLSISRLGSSSVGPEDFKDFGVELEDLQIT 457
             :.|..|.    .:|.||        :....|.:..|.||......:|.:.||.....|.:::::
Mosquito   417 -IRYLSLSRNVIRELPGD--------SFAAFRKLIYLDISGNSLGVIGEDTFKGLEGTLLEIKLS 472

  Fly   458 RASLSGIQSHAFKHVRGLKRLDFSENGISSIENDAFHEIGHSLISLKMSHGYSGSALPAEPLRHL 522
            ...::.::......   |:|||.|.|.|..:..|:||.: |:|:.|.||.......:....:..|
Mosquito   473 FNRIASLRKFVLPK---LRRLDLSANSIDDLAIDSFHSL-HNLLYLNMSGNEHVGQVTRTMIYPL 533

  Fly   523 TSLQELDFSNNHISSMSDTSFHFLKNLRLLELHDNRIEQVLKGTFQGDIHSKLEEISLRFNHLTS 587
            |.||.:|.|:..:..:....||...:||:..|:.|::..:.:|||            |..|:|
Mosquito   534 TKLQVIDLSHCGLKMLQADLFHNNTDLRIALLNHNQLRVIEEGTF------------LNLNNL-- 584

  Fly   588 ISQHTFFDLEALRKLHLDDNKIDKIERRAFMNLDELEYLSLRGNKINNLADESFQNLPKLEILDM 652
                  |||.      |..|.::::..|:|:|...|..|:||.|.:..|..:.|.....||:||.
Mosquito   585 ------FDLS------LAGNGLEQLRPRSFVNTVNLRTLNLRQNALQELRADMFTTETALEVLDA 637

  Fly   653 AFNQLPNFNFDYFDQVGTLSNLNVNVSHNQIRQLMYNSSWSGRNEHGGMYHSNIKILDLSHNNIS 717
            :.|.|.:|         ..:.|.:   |.::|:::                       |::|.:.
Mosquito   638 SDNALKSF---------ATNTLKI---HPRLRKVL-----------------------LANNRLE 667

  Fly   718 IIHPGYFRPAEISLTHLHLGYNSLMNTTRDVFGNMPHLQWLDLSYN---WIHELDFDAFKNTKQL 779
            :..|                         ::..::.||:.:||:.|   .|.:|||....|.::|
Mosquito   668 VFPP-------------------------ELIADLDHLEVIDLAGNRLTTIQQLDFGRLANLREL 707

  Fly   780 QLVFFGHNYLSDIPQDIFKPVQGLRIVDFSHNHLRGLPDNLFYNG-GMEKLDVSHNMMLKIPSSS 843
               :...|.:..:....|.....|:|:|.:.|.|..|.:..|... .:::||:|.|.:..:|...
Mosquito   708 ---YLRANAIDSVQDMAFHNSSQLQILDLAANRLERLSERSFEGTLRLDRLDLSDNKLTGLPEQV 769

  Fly   844 LSSLAALTLCELHLSNNFISTIHSMDLSNKFRSLRYLDISYNYLLRIDDAVFATMPKLAVLDLSH 908
            |:......|..:.|:.|.::::......::..:|:.||:|.|.:..:..|....|.....:|.|:
Mosquito   770 LAKSRVQRLERVSLAGNKLASVPVAAFGDQHDTLQTLDLSRNAIREVPRASHMLMINAKHVDFSY 834

  Fly   909 NRDLKVMDKSFMGLENSLIKLGLENISLSTVPEIRLKYLREFRLGYNELPSIPQELAHNMSNLRM 973
            |........:.:|...::..|.|....:..:|.:...|||...|.||.:.::..:....::.|..
Mosquito   835 NPLSPEAIATVLGQPKTVRTLNLAGTGVRELPMLETPYLRSLNLSYNNISAVSAKAFEKVTLLER 899

  Fly   974 LDLSNNDLTNVPLMTQALPHLR---RLMLSGNPITSLNNNSF---DGVNE-------DLEMLDIS 1025
            ||||:|.:.:...:....|.|.   .|.||.|||.::..::|   ||:.|       :|..|:.:
Mosquito   900 LDLSHNAIGDADGLRDIWPKLALLGYLDLSSNPIRTITASTFERLDGLTELYIRELPELTRLEKN 964

  Fly  1026 NFRLHYFEYGCLDSLPHLRSLKLTAYSHLEHFNIPHLLRHHYNIRQLWIEAPQPFTRIVKKGSGP 1090
            .|:          .|..|..|:...::.|.:.::..:::....:..:.|||        |..:..
Mosquito   965 AFK----------PLKDLTVLQAYQFAKLGYIDVQGIVQELPALAAVDIEA--------KDANLE 1011

  Fly  1091 TQEMQTLQLGNPTDLQREMEGHLPSKLTNITFSGPQFTNLNERILRGMRSPYLYMQLFNTSLQAL 1155
            :.::|.|              |.| ||..:...|....:|:.....|:|:.||.::|.||||.||
Mosquito  1012 SDQLQVL--------------HHP-KLHTLGLHGYALQSLSSGAFAGLRNKYLTVRLHNTSLTAL 1061

  Fly  1156 PPNFFKYMGRVRNISLDIRYHNRNLKKIPNPNTGAVPYLPNSVFLTDLKMSHTDLNCDCDLGWVE 1220
            ||.....:.|..:|...|.  ...:..:..|...::....||:.:..|  :...:.|||.
Mosquito  1062 PPALLLPLPRSAHIDFSIA--GSKVGTLTQPFLSSLDDRKNSIQIDGL--ATNPVRCDCQ----- 1117

  Fly  1221 FWQRKRRQYICSSQTWTDTVFRTFMNSPCQVYGRHNCDEHDDDL 1264
              .|..|::|.:::     |......||..|.|:...:..|.:|
Mosquito  1118 --ARAFRRWILATK-----VQDVRCASPPTVAGKLLTEVGDSEL 1154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chp	NP_001263137.1	LRR	<84..320	CDD:443914	83/275 (30%)
		leucine-rich repeat	84..103	CDD:275380	10/52 (19%)
		leucine-rich repeat	104..128	CDD:275380	6/23 (26%)
		leucine-rich repeat	129..152	CDD:275380	8/22 (36%)
		leucine-rich repeat	153..177	CDD:275380	7/23 (30%)
		leucine-rich repeat	178..201	CDD:275380	10/22 (45%)
		leucine-rich repeat	202..226	CDD:275380	8/23 (35%)
		leucine-rich repeat	227..250	CDD:275380	12/22 (55%)
		leucine-rich repeat	251..279	CDD:275380	9/27 (33%)
		leucine-rich repeat	280..326	CDD:275380	14/51 (27%)
		leucine-rich repeat	327..348	CDD:275380	3/20 (15%)
		leucine-rich repeat	352..375	CDD:275380	8/23 (35%)
		PPP1R42	355..564	CDD:455733	52/213 (24%)
		leucine-rich repeat	376..401	CDD:275380	4/24 (17%)
		leucine-rich repeat	426..450	CDD:275378	6/23 (26%)
		leucine-rich repeat	451..474	CDD:275380	1/22 (5%)
		LRR_8	473..559	CDD:404697	27/85 (32%)
		leucine-rich repeat	475..524	CDD:275380	16/48 (33%)
		leucine-rich repeat	500..519	CDD:275380	4/18 (22%)
		leucine-rich repeat	525..548	CDD:275380	6/22 (27%)
		LRR	<540..>834	CDD:443914	63/297 (21%)
		leucine-rich repeat	549..574	CDD:275380	7/24 (29%)
		leucine-rich repeat	575..598	CDD:275380	6/22 (27%)
		leucine-rich repeat	599..622	CDD:275380	5/22 (23%)
		leucine-rich repeat	623..646	CDD:275380	7/22 (32%)
		leucine-rich repeat	647..730	CDD:275380	13/82 (16%)
		leucine-rich repeat	648..673	CDD:275380	6/24 (25%)
		leucine-rich repeat	674..705	CDD:275380	3/30 (10%)
		LRR	<730..1081	CDD:443914	77/367 (21%)
		leucine-rich repeat	731..754	CDD:275380	0/22 (0%)
		leucine-rich repeat	755..778	CDD:275380	9/25 (36%)
		leucine-rich repeat	779..802	CDD:275380	3/22 (14%)
		leucine-rich repeat	803..823	CDD:275380	7/19 (37%)
		leucine-rich repeat	852..876	CDD:275380	3/23 (13%)
		leucine-rich repeat	877..900	CDD:275380	7/22 (32%)
		leucine-rich repeat	901..925	CDD:275380	4/23 (17%)
		leucine-rich repeat	926..946	CDD:275380	3/19 (16%)
		leucine-rich repeat	947..970	CDD:275380	5/22 (23%)
		leucine-rich repeat	971..993	CDD:275380	6/21 (29%)
		leucine-rich repeat	994..1014	CDD:275380	8/25 (32%)
		leucine-rich repeat	1019..1042	CDD:275380	4/22 (18%)
LOC1270408	XP_061508553.1	None