Protein Alignment Alp4 and ALPP

DIOPT Version :10

• Sequence 1: NP_524601.2
• Gene: Alp4 / 43671
• FlyBaseID: FBgn0016123
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_001623.3
• Gene: ALPP / 250
• HGNCID: 439
• Length: 535
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 243/599 - (40%)
• Similarity: 317/599 - (52%)
• Gaps: 84/599 - (14%)

  Fly     3 CLVILGFLLGSLVAFSWAGVTTQPPPLIRTLSAGGDIGPQFDVGKTKEPEDAEFWHNVGLRQLEK 67
            |:::|..|||                |...||.|  |.|       .|.|:.:||:    |:..:
Human     5 CMLLLLLLLG----------------LRLQLSLG--IIP-------VEEENPDFWN----REAAE 40

  Fly    68 TIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKHGYGEEETLVFDDFPNTGMA 132
            .:..|::::  ..|..|:|:|||:|||||:||::|.||.||| .|...|.|..|..|.||...::
Human    41 ALGAAKKLQ--PAQTAAKNLIIFLGDGMGVSTVTAARILKGQ-KKDKLGPEIPLAMDRFPYVALS 102

  Fly   133 KTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATR--SKKNGQQG-RVQSVMEWAQKEGKRTGV 194
            |||||||.||||..||||...|.|.::..||:.|..  ::.|..:| .|.|||..|:|.||..||
Human   103 KTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGV 167

  Fly   195 VTTTRITHATPAATYAHIYDRDWECDTEVPAES--VGFHVDIARQLVENAPGNRFNVILGGG--- 254
            |||||:.||:||.||||..:|:|..|.:|||.:  .|.. |||.||:.|..   .:||||||
Human   168 VTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQ-DIATQLISNMD---IDVILGGGRKY 228

  Fly   255 MSPMGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLAHHANDTVPPALVHNRKDLLNVNV-KK 318
            |..||..: .|......:|.     ||.|.:||..||||....    ...|.||.:|:..:: ..
Human   229 MFRMGTPD-PEYPDDYSQGG-----TRLDGKNLVQEWLAKRQG----ARYVWNRTELMQASLDPS 283

  Fly   319 VDHLMGLFRNNHITYSIAREAG-EPSLQEMTETALGILERGDESNGFVLLVEGGRIDQGHHMNYA 382
            |.||||||....:.|.|.|::. :|||.||||.||.:|.|  ...||.|.|||||||.|||.:.|
Human   284 VTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSR--NPRGFFLFVEGGRIDHGHHESRA 346

  Fly   383 RAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYALRGADILGTANSHEKNDPMFY 447
            ..||.|...||.||:.|...|..::||.||||||||..:|.||.|||:.|.|.|.. :..|...|
Human   347 YRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPG-KARDRKAY 410

  Fly   448 ETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEERAAPTYRHLATVPRKDETHGGEDVAVF 512
            ..:.|.|||||  .|.:.:||.           .|..|..:|.||..:.||..:|||.|||||||
Human   411 TVLLYGNGPGY--VLKDGARPD-----------VTESESGSPEYRQQSAVPLDEETHAGEDVAVF 462

  Fly   513 AYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKDFDDSCEDHKDGQKDRPLDKPNPKRNGATVVGA 577
            |.||.:.|:.||.||.::|:||::|.||.|....|.:          .|....:....|.:||.|
Human   463 ARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLA----------PPAGTTDAAHPGRSVVPA 517

  Fly   578 SLIPILTAATAAIL 591
             |:|:| |.|..:|
Human   518 -LLPLL-AGTLLLL 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	210/465 (45%)
ALPP	NP_001623.3	Alk_phosphatase	55..490	CDD:395188	210/465 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..449		8/34 (24%)