Protein Alignment Alp4 and ALPP

DIOPT Version :9

• Sequence 1: NP_524601.2
• Gene: Alp4 / 43671
• FlyBaseID: FBgn0016123
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_001623.3
• Gene: ALPP / 250
• HGNCID: 439
• Length: 535
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 243/599 - (40%)
• Similarity: 317/599 - (52%)
• Gaps: 84/599 - (14%)

  Fly     3 CLVILGFLLGSLVAFSWAGVTTQPPPLIRTLSAGGDIGPQFDVGKTKEPEDAEFWHNVGLRQLEK 67
            |:::|..|||                |...||.|  |.|       .|.|:.:||:    |:..:
Human     5 CMLLLLLLLG----------------LRLQLSLG--IIP-------VEEENPDFWN----REAAE 40

  Fly    68 TIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKHGYGEEETLVFDDFPNTGMA 132
            .:..|::::  ..|..|:|:|||:|||||:||::|.||.||| .|...|.|..|..|.||...::
Human    41 ALGAAKKLQ--PAQTAAKNLIIFLGDGMGVSTVTAARILKGQ-KKDKLGPEIPLAMDRFPYVALS 102

  Fly   133 KTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATR--SKKNGQQG-RVQSVMEWAQKEGKRTGV 194
            |||||||.||||..||||...|.|.::..||:.|..  ::.|..:| .|.|||..|:|.||..||
Human   103 KTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGV 167

  Fly   195 VTTTRITHATPAATYAHIYDRDWECDTEVPAES--VGFHVDIARQLVENAPGNRFNVILGGG--- 254
            |||||:.||:||.||||..:|:|..|.:|||.:  .|.. |||.||:.|..   .:||||||
Human   168 VTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQ-DIATQLISNMD---IDVILGGGRKY 228

  Fly   255 MSPMGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLAHHANDTVPPALVHNRKDLLNVNV-KK 318
            |..||..: .|......:|.     ||.|.:||..||||....    ...|.||.:|:..:: ..
Human   229 MFRMGTPD-PEYPDDYSQGG-----TRLDGKNLVQEWLAKRQG----ARYVWNRTELMQASLDPS 283

  Fly   319 VDHLMGLFRNNHITYSIAREAG-EPSLQEMTETALGILERGDESNGFVLLVEGGRIDQGHHMNYA 382
            |.||||||....:.|.|.|::. :|||.||||.||.:|.|  ...||.|.|||||||.|||.:.|
Human   284 VTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSR--NPRGFFLFVEGGRIDHGHHESRA 346

  Fly   383 RAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYALRGADILGTANSHEKNDPMFY 447
            ..||.|...||.||:.|...|..::||.||||||||..:|.||.|||:.|.|.|.. :..|...|
Human   347 YRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPG-KARDRKAY 410

  Fly   448 ETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEERAAPTYRHLATVPRKDETHGGEDVAVF 512
            ..:.|.|||||  .|.:.:||.           .|..|..:|.||..:.||..:|||.|||||||
Human   411 TVLLYGNGPGY--VLKDGARPD-----------VTESESGSPEYRQQSAVPLDEETHAGEDVAVF 462

  Fly   513 AYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKDFDDSCEDHKDGQKDRPLDKPNPKRNGATVVGA 577
            |.||.:.|:.||.||.::|:||::|.||.|....|.:          .|....:....|.:||.|
Human   463 ARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLA----------PPAGTTDAAHPGRSVVPA 517

  Fly   578 SLIPILTAATAAIL 591
             |:|:| |.|..:|
Human   518 -LLPLL-AGTLLLL 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	210/483 (43%)
		alkPPc	85..541	CDD:214515	210/465 (45%)
ALPP	NP_001623.3	PRK10518	28..478	CDD:236706	211/486 (43%)
		Alk_phosphatase	55..490	CDD:278666	210/465 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..449		8/34 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157491
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H122414
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.660