Protein Alignment Alp4 and ALPI

DIOPT Version :10

• Sequence 1: NP_524601.2
• Gene: Alp4 / 43671
• FlyBaseID: FBgn0016123
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_001622.2
• Gene: ALPI / 248
• HGNCID: 437
• Length: 528
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 238/557 - (42%)
• Similarity: 308/557 - (55%)
• Gaps: 73/557 - (13%)

  Fly    50 EPEDAEFWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKHG 114
            |.|:..||:    ||..:.:..|::::  ..||.|:|:|:|:|||:|:.|::|.||.|||  |:|
Human    24 EEENPAFWN----RQAAEALDAAKKLQ--PIQKVAKNLILFLGDGLGVPTVTATRILKGQ--KNG 80

  Fly   115 -YGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATR--SKKNGQQG 176
             .|.|..|..|.||...::||||||:||||||.||||...|.|.::..||:.|..  ::.|..:|
Human    81 KLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRG 145

  Fly   177 -RVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAES--VGFHVDIARQL 238
             .|.|||..|::.||..|||||||:.||:||.||||..:|:|..|.::||.:  .|.. |||.||
Human   146 NEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQ-DIATQL 209

  Fly   239 VENAPGNRFNVILGGG---MSPMGILNASEVKTTIFEGPTETICT--RGDNRNLPAEWLAHHAND 298
            :.|..   .:||||||   |.|||        |...|.|.:....  |.|.:||..||||.|..
Human   210 ISNMD---IDVILGGGRKYMFPMG--------TPDPEYPADASQNGIRLDGKNLVQEWLAKHQG- 262

  Fly   299 TVPPALVHNRKDLLNVNV-KKVDHLMGLFRNNHITYSIAREAG-EPSLQEMTETALGILERGDES 361
               ...|.||.:|:..:: :.|.||||||......|.|.|:.. :|||.||||.||.:|.|  ..
Human   263 ---AWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSR--NP 322

  Fly   362 NGFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYA 426
            .||.|.|||||||.|||...|..||.|...||.||:.|...|..::||.||||||||..:|.||.
Human   323 RGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYT 387

  Fly   427 LRGADILGTANSHEKNDPMFYETISYANGPGYWDHLANDS-RPQ-NSSNMWMPLKHFTAEERAAP 489
            |||:.|.|.|.| :..|...|.:|.|.|||||   :.|.. ||. |.|            |..:|
Human   388 LRGSSIFGLAPS-KAQDSKAYTSILYGNGPGY---VFNSGVRPDVNES------------ESGSP 436

  Fly   490 TYRHLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKDFDDSCEDHK 554
            .|:..|.||...||||||||||||.||.:.|:.||.||:::|:||::|.||.|.    .:|:
Human   437 DYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPY----TACD--- 494

  Fly   555 DGQKDRPLDKPNPKRNGATVVGASLIPILTAATAAIL 591
                   |..|....:.|..|.||| |:| |.|..:|
Human   495 -------LAPPACTTDAAHPVAASL-PLL-AGTLLLL 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	213/470 (45%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:395188	213/470 (45%)