Protein Alignment tll and NR2E1

DIOPT Version :10

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_001273031.1
• Gene: NR2E1 / 7101
• HGNCID: 7973
• Length: 422
• Species: Homo sapiens
• Alignment Length: 440
• Identity: 178/440 - (40%)
• Similarity: 246/440 - (55%)
• Gaps: 64/440 - (14%)

  Fly    20 LSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTH 84
            |..:...||| .:|||||.|.|||||||:||||||:|||||||||:|.|||||..||.|.|||||
Human    40 LLESPGGRIL-DIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTH 103

  Fly    85 RNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALT 149
            |||||||||:||.||.|||||||||||||.||:|:.:|:|   ..|..|          ...|..
Human   104 RNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALY---FRGHKE----------ENGAAA 155

  Fly   150 GFPGVPMPMPGL---PQRAGHHPAHMAAFQPPPSAAAVLDLS--VPRVPHHPVHQGHHGFFSPTA 209
            .||...:|.|..   ..:...|...:||....|....::.|:  .|:.||.         .:.|.
Human   156 HFPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHE---------VNGTP 211

  Fly   210 AYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFI 274
            .|:..:||            |.:.|:||..||.::.|.|||.||:.|.:.|||:|||::|:|.|:
Human   212 MYLYEVAT------------ESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFV 264

  Fly   275 LAMAQYLMPMNFAQLLFV--YESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAIS 337
            |.:||:.:|::...||.|  ...:|.:.:.:..:..|:.|.|||:.:...|.:|:||:.||:.|.
Human   265 LGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIV 329

  Fly   338 LFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPS 402
            .|:..|               |.|||       |.|....:..:||:.::|:..|::||...:|:
Human   330 TFKAVP---------------THSGS-------ELRSFRNAAAIAALQDEAQLTLNSYIHTRYPT 372

  Fly   403 QPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQRKI 452
            ||.||..||.::..:..:|..||||:||:||||::.|.||:||||....|
Human   373 QPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	72/91 (79%)
		NR_LBD	215..436	CDD:472173	75/222 (34%)
NR2E1	NP_001273031.1	NR_DBD_TLX	45..136	CDD:143537	72/91 (79%)
		NR_LBD_Tlx_PNR_like	191..406	CDD:132748	81/257 (32%)