Protein Alignment tll and nhr-221

DIOPT Version :10

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_503987.1
• Gene: nhr-221 / 188826
• WormBaseID: WBGene00020748
• Length: 398
• Species: Caenorhabditis elegans
• Alignment Length: 453
• Identity: 90/453 - (19%)
• Similarity: 157/453 - (34%)
• Gaps: 122/453 - (26%)

  Fly    16 NSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVV 80
            |:|.:. ..|::||....|.||...:.|.|..:..|.||..||:|......:..|.:  .|.| .
 Worm    17 NNVEIK-LISTKILKPSKCMVCVRPAHGYHCDVATCKGCKTFFRRMCLLRGEIKCST--SGDC-Y 77

  Fly    81 DKTHRN----QCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEI 141
            |...||    :||.||.::|..||||         |:        |:..|.....||     .::
 Worm    78 DLEKRNSPLLRCRPCRFKRCLLVGMN---------PK--------ALIIDGSNILGE-----KQV 120

  Fly   142 LMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQP------------PPSAAAVLDLSVPRVPH 194
            ..|...:.|...|...:....::..     ..|:.|            .||..::.| .|...|.
 Worm   121 HFNEQQIQGTIDVLSHLEAKTEQFS-----KCAYNPDWTNIRLKDLILSPSKLSMSD-KVGTFPD 179

  Fly   195 HPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMP 259
            .|:        .|...:.:.:..|.:....|     |.|:....:|...|.:.|:...|.:|...
 Worm   180 WPL--------CPNYEFPDQIVHRDIQSFSP-----HRKQWRFSNLMTAVEYTKTFSFFHDLSFQ 231

  Fly   260 DQLLLLEESWKEFFILAMAQ-----YLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQ 319
            ||:.||:.     .::.:|.     |.:...|..|   .:.:...|.  |:......|.......
 Worm   232 DQINLLKH-----VVIGLANFNTTYYTLKNKFDDL---RQPDGTQRP--GVNEPHYCAHTVPFGP 286

  Fly   320 LCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAM 384
            :..:.|...|:..|:.  ||            :.|.::      ||.|..|:.  ::|..:
 Worm   287 MKRIKIQFNEFLLLKI--LF------------VCNPAV------PNLSKHAQF--VIEKER---- 325

  Fly   385 HNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMY 447
            |:.: :.|..|..:.:...|.||..|:.:..::|:..                   :|::|:|
 Worm   326 HHYS-NILLKYCLQNYSYGPTRFVELIEIFGVLHRQQ-------------------KLMNDLY 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	30/95 (32%)
		NR_LBD	215..436	CDD:472173	39/225 (17%)
nhr-221	NP_503987.1	ZnF_C4	33..105	CDD:197701	26/83 (31%)
		HOLI	209..360	CDD:214658	35/187 (19%)