Protein Alignment tll and nhr-173

DIOPT Version :10

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_509119.4
• Gene: nhr-173 / 183862
• WormBaseID: WBGene00016975
• Length: 508
• Species: Caenorhabditis elegans
• Alignment Length: 451
• Identity: 107/451 - (23%)
• Similarity: 174/451 - (38%)
• Gaps: 98/451 - (21%)

  Fly    30 YHVP-------CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLC--VVDKTHR 85
            :|:|       |.||.|.::|.||.:.:|:||..||:|::...|:|.|  .:.|.|  |:.|..|
 Worm    92 HHLPRNVCPTICAVCGDRATGYHYEVPSCNGCKTFFRRTVLSQRKYEC--MRGGKCFNVLPKEKR 154

  Fly    86 NQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYK----------DAMMGAGEMPQIPAE 140
            ..||:||.:||.|||||..|:|     .|.:|..:..:.|          :::....::..:|..
 Worm   155 CSCRSCRFQKCVEVGMNPFAIQ-----TNDSLSSNAVVTKIVGKRKNSVDNSIPSTSKLTVLPEV 214

  Fly   141 ILMNTA---ALTGFPGVPMPMPGLPQRAGHHPAH-------MAAFQPPPSAAAVLDLSVPRVPHH 195
            |.|:.|   .:.|...:.:.:......|.:.|.|       ....||..|.|..|.    .:|:.
 Worm   215 ISMDNAIDRLIDGLMYLEIKVDDFRSCAYNPPTHEYRSLKYHLEQQPMISMADKLG----PMPNW 275

  Fly   196 PVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPD 260
            |:.|..|   .....|:.  :..:.|.||      ..|......:..:|.:.|:.....::...|
 Worm   276 PLRQISH---EEMKEYIE--SGNSEPMTP------ERKNWFVYDILTSVEYAKTFMFLHQIGKED 329

  Fly   261 QLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYE--------------------SENANREIMGM 305
            |:|||.         |:...||.:|  |..:.||                    :||.|..|..|
 Worm   330 QILLLR---------AVVLKLMHLN--QAFYSYENKYDMIFHPDGTVPPHSWKKNENPNDSISQM 383

  Fly   306 VTRE-----VHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPN 365
            :|::     ...|...:.|.....:|..||...:||:|..   .:.|...|.|. .::|......
 Worm   384 MTKQKMEEMKEEFTLSIRQFVTYQLDKREYVLFKAITLCN---ATISGLSDHAR-EVVTREKEKY 444

  Fly   366 SSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQ-PMRFQTLLGVVQLMHKVSSFTI 425
            |.|..: ..|...|.....|..|..||.|.::....:| ...|     ::::|.|...|.:
 Worm   445 SKALMK-YCLANRGMKGPAHYAAIIALSNGLENRQKNQKDFHF-----IMKMMKKGFKFDL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	37/95 (39%)
		NR_LBD	215..436	CDD:472173	50/237 (21%)
nhr-173	NP_509119.4	NR_DBD_HNF4A	103..180	CDD:143518	35/83 (42%)
		HOLI	307..476	CDD:214658	41/184 (22%)