Protein Alignment tll and nhr-136

DIOPT Version :10

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_506039.2
• Gene: nhr-136 / 182566
• WormBaseID: WBGene00003726
• Length: 435
• Species: Caenorhabditis elegans
• Alignment Length: 515
• Identity: 113/515 - (21%)
• Similarity: 169/515 - (32%)
• Gaps: 172/515 - (33%)

  Fly     7 SPDMM---------DQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSI 62
            ||:::         |.|.:|::...|..||......|||||..::|.||.:.:|:||..||:|||
 Worm    17 SPELLLPNMDENLEDSKPSSLKYQKAMMSRGTCPSNCKVCRHSATGYHYDVPSCNGCKTFFRRSI 81

  Fly    63 RRSRQYVCKSQKQ---GLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMY 124
            ...|:|.|...::   |...||.: |..|||||..||.|.|||..|:|.:....:..|.|...|.
 Worm    82 LDGRKYTCLKMRKCLSGTEPVDLS-RRMCRACRFEKCVEAGMNPSAIQADMKTTDGELLRKEIMI 145

  Fly   125 KDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSV 189
            |          |..|...:||      |.|.|......|                  ..:..|:|
 Worm   146 K----------QKTAVDFLNT------PQVIMSFEDKVQ------------------GIIGKLTV 176

  Fly   190 PRVPHHPVHQGHHGFFSPTAAYMNALATRALPP-------------TPPLMAAEHIKETAAEHLF 241
            ..:...|::.|                  .|||             .|.:::.:.|
 Worm   177 MELKIEPLYTG------------------GLPPGNRDIRKLDELIDAPLILSYDEI--------- 214

  Fly   242 KNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLL---------------- 290
            .|:.:..||...|....|.....:...:     ||..:|....:||..:
 Worm   215 PNLKYCPSVDELTGEIKPSGACYIHCGY-----LASIEYSKMFDFAHKIDVASKATLIKHATIMC 274

  Fly   291 -------FVYESENANREI--MGMV------------TREVHAFQEVLNQLCHLNIDSTEYECLR 334
                   |.|....::|.|  .||.            |:...:.|..|..:....::..||..|:
 Worm   275 ADIMTAFFSYYQRKSDRLIHPNGMFAGPPKYRYGEAGTKYQASMQRTLATVLRHELNRIEYMLLK 339

  Fly   335 AISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRT 399
            ||.|..   |:.||........|  |........:..:..||..|.|           |.
 Worm   340 AIVLCN---PAVSSLSISVQQII--GKEREEYVRTLLTYCLLNYGSV-----------HG----- 383

  Fly   400 HPSQPMRFQTLLGVVQLM----------HKVSSFTIEELFFRKTIGDITIVRLISDMYSQ 449
                |.||..||.::.::          |.::..||        :.|......||::|.|
 Worm   384 ----PSRFSALLAIMSVLESQQKNAKDFHLLAKATI--------LKDAVRYTRISNLYEQ 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	38/94 (40%)
		NR_LBD	215..436	CDD:472173	48/280 (17%)
nhr-136	NP_506039.2	NR_DBD_HNF4A	53..128	CDD:143518	35/75 (47%)
		HOLI	243..400	CDD:214658	35/181 (19%)