Protein Alignment tll and nhr-154

DIOPT Version :10

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_506037.2
• Gene: nhr-154 / 182565
• WormBaseID: WBGene00007547
• Length: 469
• Species: Caenorhabditis elegans
• Alignment Length: 492
• Identity: 110/492 - (22%)
• Similarity: 175/492 - (35%)
• Gaps: 127/492 - (25%)

  Fly     4 SEGSPDMMDQKYNSVRLSPAASSRILYHVP-------CKVCRDHSSGKHYGIYACDGCAGFFKRS 61
            |...||:.         ||.|..:|...:|       |.|||:.:.|.||.:.:|:||..||:|:
 Worm    55 SASPPDIS---------SPFADEKIYKSLPRNKCPSKCLVCRNPAIGYHYDVPSCNGCKTFFRRT 110

  Fly    62 IRRSRQYVCKSQKQ---GLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAM 123
            |...|::.|..||:   |...||.:.| .|||||..||.|||||..|:|.|.......:.|...:
 Worm   111 IITGRKFTCAKQKKCMDGTEPVDMSKR-LCRACRFAKCVEVGMNPMAIQAEVKTDEGKVLRSEVL 174

  Fly   124 YKDAMMGAGEMPQIPAEILMN--TAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLD 186
            .:...:|......:..|.|::  ...||.......|:    .|:|..|    .::.......:||
 Worm   175 NQRESLGVVSSLIVTEEDLLSRMIEKLTFVESKVEPL----HRSGMPP----GYRDIRKLEEILD 231

  Fly   187 ----LSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWI 247
                |.|..:|:..        |.|:..     |....|       ..|...........::...
 Worm   232 SKPVLVVTDIPNLK--------FCPSPC-----ANEKRP-------RRHFTNYVHTSYLASLESS 276

  Fly   248 KSVRAFTELPMPDQLLLLEES-------WKEFFIL-------------AMAQYLMPMNFAQLLFV 292
            |.....::|.:..::||::.:       ...||.:             :|:.::..
 Worm   277 KMFEFSSQLDLESRILLMKHATLICSNMMNAFFSINEMKSDILRHPDGSMSGHMRK--------- 332

  Fly   293 YESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSI 357
            ::.||      .::|..|...|:.|....:..:|..||...:||.|...:.|
 Worm   333 FDREN------DVMTDHVKLIQKTLITFLNHKVDKIEYLLFKAIMLCNPAVP------------- 378

  Fly   358 LTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNY--IQRTHPSQPMRFQTLLGVVQLMHKV 420
              |..|.|.....:.|            |....||.||  :|......|.||.|:|.:..::...
 Worm   379 --GLDSWNQEIIEKER------------NQYVKALLNYCLLQHGKLQGPTRFATILAMAPIIENQ 429

  Fly   421 SS------FTIEELFFR--KTIGDITIVRLISDMYSQ 449
            |.      ..|:...|:  |.:| .|..:.||.|:.|
 Worm   430 SKNQKDFHVYIKAKHFQKHKKMG-TTFRKCISCMFDQ 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	39/101 (39%)
		NR_LBD	215..436	CDD:472173	42/250 (17%)
nhr-154	NP_506037.2	NR_DBD_HNF4A	83..160	CDD:143518	36/77 (47%)
		HOLI	266..429	CDD:214658	35/204 (17%)