Protein Alignment tll and nhr-149

DIOPT Version :10

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_504874.2
• Gene: nhr-149 / 182174
• WormBaseID: WBGene00015397
• Length: 375
• Species: Caenorhabditis elegans
• Alignment Length: 443
• Identity: 86/443 - (19%)
• Similarity: 154/443 - (34%)
• Gaps: 107/443 - (24%)

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHR-----NQCRACRL 93
            |.:|...:.|.||.:.:|.||..||:|......:.:|....:  | .|...|     ::|||||.
 Worm     7 CSICSRPAQGYHYDVISCKGCKTFFRRMWLSKIKEMCPLNNK--C-FDFNRRINMSLSKCRACRF 68

  Fly    94 RKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPM 158
            ::|..||||..|:|.:..|:..:     :.::|       ...|..:|......||   .|.:.:
 Worm    69 QRCLNVGMNPAAIQCDGNPKKDS-----SHFRD-------FDSIDEKIKNIIDTLT---YVELKL 118

  Fly   159 PGLPQRAGHHPAHMAAFQPPPSAAAVLD--------LSVPRVPHHPVHQGHHGFFS---PTAAYM 212
            ...         ..:|:.|..|.:..||        ||:..: :.|:.....||..   |:::..
 Worm   119 ENY---------RKSAYNPVLSLSTGLDDLIEGSCSLSLAEI-YGPMSGWPLGFEEHQLPSSSMR 173

  Fly   213 NALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAM 277
            |.......|       ..:.|.....::...:.:.|:.:.|.||...|:.:|...:......|.:
 Worm   174 NVSCEEPCP-------VSNRKYWTHCNMLTTIEYFKTFKFFHELSSRDKFVLARHTLLLCQNLHI 231

  Fly   278 AQYLMPMNFAQLL----FVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISL 338
            :.|.:..||...|    .:...::.....:.|::         :..|....|...||..|:||..
 Worm   232 SHYTVSHNFDSCLQPDGSMQPKQDERHYPIAMMS---------IEPLVRCKIQHVEYVLLKAICF 287

  Fly   339 FRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQ 403
            ...:.|..|...    ..||           |:.|...            ...|.|:..|.:...
 Worm   288 CNPAVPELSQNA----QRIL-----------AKERYCF------------ADILINHCLRNYTDG 325

  Fly   404 PMRFQTLLGVVQL----------MHKVSSFTIEELFFRKTIGDITIVRLISDM 446
            |..|..|:|:..|          :|.:....:...|.|:      :::.:||:
 Worm   326 PGHFAELIGIFNLLETQQRMFKDLHIMYVVPLMNKFSRE------LIKFLSDV 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	28/87 (32%)
		NR_LBD	215..436	CDD:472173	38/234 (16%)
nhr-149	NP_504874.2	ZnF_C4	6..78	CDD:197701	24/73 (33%)
		HOLI	190..342	CDD:214658	33/187 (18%)