Protein Alignment tll and nhr-148

DIOPT Version :10

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_504871.1
• Gene: nhr-148 / 182172
• WormBaseID: WBGene00015396
• Length: 370
• Species: Caenorhabditis elegans
• Alignment Length: 445
• Identity: 107/445 - (24%)
• Similarity: 161/445 - (36%)
• Gaps: 141/445 - (31%)

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQ----CRACRLR 94
            |.:||.::.|.||.:.:|.||..||:|....:.|..|....|  | .|.|..|:    |||||.|
 Worm    11 CSICRRNAKGYHYDVISCKGCKTFFRRMSLINFQGKCDLNNQ--C-FDLTKANEPYLRCRACRYR 72

  Fly    95 KCFEVGMNKDAVQHERGPRNSTLRRHMAMYK---DAMMG----------AGEMPQIPA----EIL 142
            ||.:||||:.|:|...  ||.|......|.|   ||::.          :.:.|...|    |:.
 Worm    73 KCLDVGMNQKAIQIPE--RNQTFGVIETMTKNTIDALVYLEEKLEKFRLSADNPHWQAVSDLELY 135

  Fly   143 MNTAALTGFPGVPMPMPGLPQRAG---HHPAHMAAFQP----PPSAAAVLDLSVPRVPHHPVHQG 200
            :|..:..          ||..:.|   .:..| .:|:|    |.|..||.:..:...|...:.
 Worm   136 LNNGSNL----------GLADKFGPTFENSVH-ESFEPKNSLPSSLKAVQNNKLNHCPTKKIW-- 187

  Fly   201 HHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLL 265
                     ...|.|                   |..|:| |..|:.|.:.|..:|.:...::|:
 Worm   188 ---------TLCNLL-------------------TTVEYL-KTFNYFKDLSALDKLILARHVILI 223

  Fly   266 EESWKEFFILAMAQYLMPMNFAQLLFVYESENANREIMGMVTREVH---AFQEVLNQLCHLNIDS 327
            .::      |.::.|.....|...|.: |::         ..||.|   ||. ::..|....|..
 Worm   224 GKN------LHISNYSFSKKFTGCLNI-ETD---------AQRERHYPVAFM-LMAPLIRSQIQP 271

  Fly   328 TEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSAL 392
            .||..|:||.              ..|.::      ||.|..|:|....|.|:..       |.|
 Worm   272 IEYILLKAIC--------------CCNPAV------PNLSQKAQSTLARERGQFV-------SIL 309

  Fly   393 HNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMY 447
            .:|.||:..:.|.||..|:|:..:|.|..                   |:..|||
 Worm   310 FDYCQRSGKNGPGRFAELIGIFSVMEKQQ-------------------RMQKDMY 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	35/86 (41%)
		NR_LBD	215..436	CDD:472173	47/223 (21%)
nhr-148	NP_504871.1	ZnF_C4	10..80	CDD:197701	29/71 (41%)
		HOLI	191..337	CDD:214658	47/209 (22%)