Protein Alignment tll and nhr-147

DIOPT Version :10

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_504873.2
• Gene: nhr-147 / 182170
• WormBaseID: WBGene00015395
• Length: 373
• Species: Caenorhabditis elegans
• Alignment Length: 447
• Identity: 88/447 - (19%)
• Similarity: 160/447 - (35%)
• Gaps: 102/447 - (22%)

  Fly    25 SSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGL---CVVDKTHRN 86
            |:..:..:.|.||...:.|.||.:.:|.||..||:|......:.:|     ||   | .|..::|
 Worm     5 SNNFITPITCSVCGRSAKGYHYDVISCKGCKTFFRRMYLLKSKIIC-----GLNNSC-FDLKNKN 63

  Fly    87 Q----CRACRLRKCFEVGMNKDAVQHERGPR--NSTLRRHMAMYKDAMMGAGEMPQIPAEILMNT 145
            :    |||||.:||.:||||::.:|.....:  |.|.:.:..:.:.            |:.:||:
 Worm    64 EPYLRCRACRYKKCIDVGMNRNGIQSSESKKEFNKTQKLNFQVMES------------ADDVMNS 116

  Fly   146 AALTGFPGVPMPMPGLPQRAGHHPAHM-----AAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFF 205
                           :.:|..:..:.:     ::|.|..|:.:.|...:.....          .
 Worm   117 ---------------IIERLSYVESKLEIFRTSSFNPQWSSFSSLKYLLEGTCQ----------L 156

  Fly   206 SPTAAYMNALATRALP--PTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEES 268
            |.|....|.|....:.  ||.......:.|.....:|.....:||:...|.::...|:|:|....
 Worm   157 SSTEKSENGLEKIYIIDFPTGNQYTKTNKKIWTLCNLLTITEYIKTFECFHKISSNDRLVLTRHI 221

  Fly   269 WKEFFILAMAQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEV-LNQLCHLNIDSTEYEC 332
            .....||..:.|.:...|...|....::.:..|:.       |:...: ::.|...:|...||..
 Worm   222 ILMCKILHESHYAVSRKFDNYLNPDGTQESKTEMH-------HSLLAMSISPLVRTHIQPVEYVL 279

  Fly   333 LRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQ 397
            |:|:.              ..|.:: ||......:..|:.|            ....:.|.:..:
 Worm   280 LKAMC--------------FCNPAV-TGLSQHAQTTLAKER------------QQFGNLLFDLCR 317

  Fly   398 RTHPSQPMRFQTLLGVV------QLMHKVSSFTIEELFFRKTIGDITIVRLISDMYS 448
            :.....|..|..|:|::      |.|.|.:..|....|....  |:..|:|..|:.|
 Worm   318 KNRRDGPGHFVELVGILGLLENQQRMLKDTYMTYYAPFLSPE--DVRGVKLFYDIMS 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	32/100 (32%)
		NR_LBD	215..436	CDD:472173	39/229 (17%)
nhr-147	NP_504873.2	ZnF_C4	13..85	CDD:197701	29/77 (38%)
		HOLI	192..340	CDD:214658	30/181 (17%)