Protein Alignment wts and LATS1

DIOPT Version :10

• Sequence 1: NP_733403.1
• Gene: wts / 43651
• FlyBaseID: FBgn0011739
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: XP_016866963.1
• Gene: LATS1 / 9113
• HGNCID: 6514
• Length: 1163
• Species: Homo sapiens
• Alignment Length: 1114
• Identity: 469/1114 - (42%)
• Similarity: 558/1114 - (50%)
• Gaps: 337/1114 - (30%)

  Fly   151 SGAGSSRSDSPHSH----------HTHQPSSRT-VGNPGGNGGFS---------------PSPSG 189
            |..||..|..|..|          |:..|:|:| ||.|....|.|               |.|..
Human   177 SWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPPQ 241

  Fly   190 FSEVAPPAPPPRNPTACSAATPPPPV--PPTSQA--------YVKRR--------------SPAL 230
            ...|.|| ||||..|.....|.|||.  .|.||.        ||..|              .|.|
Human   242 VRSVTPP-PPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPL 305

  Fly   231 NNRPPAIAPPTQR---------GNSPVITQN-----------GLKNPQQQLTQQLKSLNLYPGGG 275
            |..|  :.||.|.         |..|:|.|:           |::|...| |..:...|:.|.|.
Human   306 NTSP--MNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQ-TDFMIHQNVVPAGT 367

  Fly   276 SGAVVEPPPPYLIQGGAGGAAP-------PPPPPSYT--ASMQSRQSPT---------------- 315
            ...  :|||||.:. .|.|.:|       ...|.|||  :..||...|.
Human   368 VNR--QPPPPYPLT-AANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGL 429

  Fly   316 -----QSQQSDYRKSPSSG-------------------------IYSATSAGSPSPITVSLPPAP 350
                 ||..:..:.|||||                         .:||.|..|.:.:| ::.|||
Human   430 QTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVT-AITPAP 493

  Fly   351 LAKPQPRVYQARSQQPIIMQSVKSTQVQKPVLQTAVAPQSPSSASASNSPVHVLAAPPSYPQKSA 415
            :            |||     |||.:|.||.||||:||..||...   .|:..: .|..:|:.:|
Human   494 I------------QQP-----VKSMRVLKPELQTALAPTHPSWIP---QPIQTV-QPSPFPEGTA 537

  Fly   416 AVVQQQQQAAAAAHQQQHQHQQSKPPTPTTPPLVGLNSKPNCLEPPSYAKSMQAKAATVVQQQQQ 480
            :.|...                  ||....|...|        .||.|.|
Human   538 SNVTVM------------------PPVAEAPNYQG--------PPPPYPK--------------- 561

  Fly   481 QQQQQQQVQQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRERDQRERERDQQKLANGNPGRQML 545
                                                                 .|.:.||.
Human   562 -----------------------------------------------------HLLHQNPS---- 569

  Fly   546 PPPPYQSNNNNNSEIKPPSCNNNNIQISNSNLATTPPIPPAKYNNNSSNTGANSSGGSNGSTGTT 610
             .|||:|.:..:.|.:|.....:..:.|..|:                     .||.......||
Human   570 -VPPYESISKPSKEDQPSLPKEDESEKSYENV---------------------DSGDKEKKQITT 612

  Fly   611 ASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQRTYRK 675
                         |||..||   .:|:|||:|.||:.|||||||||||||:|||:||::||.:||
Human   613 -------------SPITVRK---NKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRK 661

  Fly   676 NQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKID 740
            .|||.||.:|||....|.:|||||.|||||||||||||||||||||:|.:|:||||||.|..|:|
Human   662 KQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVD 726

  Fly   741 TSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDL 805
            | ..|||.|||||.|||.|||||||||||||||||||.|||:||||||||||||||||||||||:
Human   727 T-KALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDM 790

  Fly   806 MSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRW 870
            |||||::|||.|.||||||||:||||:||||||||||||||||||||||||||||||||||||||
Human   791 MSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRW 855

  Fly   871 THNSKYYQENGNHSRQDSMEPWEEYSEN-----GPKPTVLERRRMRDHQRVLAHSLVGTPNYIAP 930
            ||:||||| :|:|.|||||:...|:.:.     |.:...||||..|.|||.||||||||||||||
Human   856 THDSKYYQ-SGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAP 919

  Fly   931 EVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQK----------------------- 972
            |||.|:|||||||:|||||||:|||||||||||.:|||||.|
Human   920 EVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKPGMVAHTCNPSALEGHSRKNTGT 984

  Fly   973 ----------VINWEKTLHIPPQAELSREATDLIRRLCASADKRLGKS-VDEVKSHDFFKGIDF- 1025
                      ||||:.:|||||||:||.||:|||.:||...:.||||: .||:|:|.|||.|||
Human   985 QEFEIGLGNIVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFS 1049

  Fly  1026 ADMRKQKAPYIPEIKHPTDTSNFDPVDPEKLRSNDSTMSSGDDV-----DQNDRTFHGFFEFTFR 1085
            :|:|:|.|.|||:|.|||||||||||||:||.|:|:...:.:|.     .......|.|:|||||
Human  1050 SDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFR 1114

  Fly  1086 RFFDDKQPP 1094
            |||||...|
Human  1115 RFFDDNGYP 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	MobB_LATS1	644..718	CDD:439273	54/73 (74%)
		STKc_LATS	717..1078	CDD:270749	264/405 (65%)
LATS1	XP_016866963.1	UBA_LATS1	103..143	CDD:270580
		PRK10263	<448..>596	CDD:236669	48/268 (18%)
		MobB_LATS1	629..704	CDD:439273	54/74 (73%)
		Protein Kinases, catalytic domain	703..1117	CDD:473864	272/415 (66%)