Protein Alignment wts and STE20

DIOPT Version :10

• Sequence 1: NP_733403.1
• Gene: wts / 43651
• FlyBaseID: FBgn0011739
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: NP_011856.1
• Gene: STE20 / 856382
• SGDID: S000000999
• Length: 939
• Species: Saccharomyces cerevisiae
• Alignment Length: 1153
• Identity: 238/1153 - (20%)
• Similarity: 383/1153 - (33%)
• Gaps: 384/1153 - (33%)

  Fly    86 PPAIVGQPGAGSI----------SVSGVGVGVVGVANGRVPKMMTALMPNKLIRKPSIERDTASS 140
            |.|:...|...|:          ::.|.|.|..|:   |:|:....|..|      ::::.|.::
Yeast     5 PSAVSELPDKDSLDNGISNDNERAMGGNGDGGDGL---RLPRTTGTLNVN------ALQKGTNAA 60

  Fly   141 H----YLRCSPA---------------LDSG------------AGSSRSDSPHSHHTHQPSSRTV 174
            |    |....||               ||..            :|.|.|.||||:.....|...|
Yeast    61 HEAGGYKSMDPAKNAETTNDDDNNVVSLDDPIQFTRVSSSSVISGMSSSMSPHSNIDETKSLEAV 125

  Fly   175 GNPGGNGGFSPSPSG---FSEV-APPAPPPRNPTACSAATPPPPVPP-TSQAYVKRRSPALNNRP 234
            .........:|..|.   ||.: |..:....|.|..|..:....... .:.|.||.:.|
Yeast   126 TPNINTSNITPDHSADNTFSTINASESDHQFNDTLLSKLSLTDSTETIENNATVKHQQP------ 184

  Fly   235 PAIAPPTQRGN-------------SPVITQNGLKNPQQQLTQQLKSLNLYPGGGSGAVVEPPPPY 286
              :|..|...|             :|||::..:....:|:.....||:..........|:|..|
Yeast   185 --VASSTVNSNKSSTDIRRATPVSTPVISKPSMTTTPRQINSASHSLSNPKHKQHKPKVKPSKP- 246

  Fly   287 LIQGGAGGAAPPPPPPSYTASMQSR-----QSPTQSQ-QSDYRKSPSSGIYSATSAGSPSPITVS 345
                     .....|.|...|..|:     .||.:.| :..|..|.|....|.:::|:
Yeast   247 ---------EAKSKPVSVKKSFPSKNPLKNSSPPKKQTEKSYYSSSSKKRKSGSNSGT------- 295

  Fly   346 LPPAPLAKPQPRVYQARSQQPIIMQSVKSTQVQ--KPVLQTAVAPQSPSSASASNSPVHVLAAPP 408
                                 :.|:.|.::.||  |...|......|.|:.|:|:|....|....
Yeast   296 ---------------------LRMKDVFTSFVQNIKRNSQDDKRASSSSNNSSSSSITTALRIST 339

  Fly   409 SYPQKSAAVVQQQQQAAAAAHQQQHQHQQSKPPTPTTPPLVGLNSKPNCLE--PPSYAKSMQAKA 471
            .|..|                   |.|.            ||::||.....  |..:.|.:.:..
Yeast   340 PYNAK-------------------HIHH------------VGVDSKTGEYTGLPEEWEKLLTSSG 373

  Fly   472 ATVVQQQQQQQQQQQQVQQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRERDQRERERDQQKLA 536
            .:..:|||..|.....|:..|                          |..|.:..::........
Yeast   374 ISKREQQQNMQAVMDIVKFYQ--------------------------DVTETNGEDKMFKTFNTT 412

  Fly   537 NGNPGRQMLPPPPYQSNNNNNSEIKPPSCNNNNIQISN-----SNLATTPPIPPAKYNNNSSNTG 596
            .|.||...:..||..|.|.     .|||.::::...|.     ||...:|.:          ||.
Yeast   413 TGLPGSPQVSTPPANSFNK-----FPPSTSDSHNYGSRTGTPMSNHVMSPTL----------NTD 462

  Fly   597 ANSSGG----SNGSTGTTASSSTSCKKIK--------HASPI-------------PERKKISKEK 636
            ::|:.|    |..:....:|:|.|...||        :.||:             |.|..||:..
Yeast   463 SSSANGKFIPSRPAPKPPSSASASAPIIKSPVMNSAANVSPLKQTHAPTTPNRTSPNRSSISRNA 527

  Fly   637 EEERKEFRIRQYSPQAFK-------FFMEQHIENVIKSYRQRTYRKNQLEKEMHKVGLPDQTQIE 694
            ..:::|..:....|...|       ....|.:....|:..|.|            |..|.....:
Yeast   528 TLKKEEQPLPPIPPTKSKTSPIISTAHTPQQVAQSPKAPAQET------------VTTPTSKPAQ 580

  Fly   695 MR---KMLNQKESNYIRLKRAKMDKSMFVKLK----------------PIGVGAFGEVTLVSKID 740
            .|   |.||:|:    |.:|.:..|.::.||.                .||.||.|.|....:|.
Yeast   581 ARSLSKELNEKK----REERERRKKQLYAKLNEICSDGDPSTKYANLVKIGQGASGGVYTAYEIG 641

  Fly   741 TSNHLYAMKTLRKADVLKR----NQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIP 801
            | |...|:|.:......|:    |::..:|..:       :..:|....|:..|.:|:.:|:|:.
Yeast   642 T-NVSVAIKQMNLEKQPKKELIINEILVMKGSK-------HPNIVNFIDSYVLKGDLWVIMEYME 698

  Fly   802 GGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCT 866
            ||.|..::....:.|.::.. ...|....::.:|..|.:|||||.||||:..:|.|||||||.|.
Yeast   699 GGSLTDVVTHCILTEGQIGA-VCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCA 762

  Fly   867 GFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPE 931
                                       :.:|...|.|                ::||||.::|||
Yeast   763 ---------------------------QINELNLKRT----------------TMVGTPYWMAPE 784

  Fly   932 VLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPL---------------------ETQQKVIN 975
            |:.|..|....|.||:|:::.||:.|:||:|..:||                     .:.:|.::
Yeast   785 VVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLD 849

  Fly   976 WEKTLHIPPQAELSREATDLIRRLCASADKRLGKSVDEVKSHDFFKGIDFADMRKQKAPYI--PE 1038
            |  .|.:.|:...|  ||:|:                    ||.:. .:.|:.....||.:  ..
Yeast   850 W--CLCVEPEDRAS--ATELL--------------------HDEYI-TEIAEANSSLAPLVKLAR 889

  Fly  1039 IKH-----PTDTSNFDPVDPEKLR-------SNDSTMSSGDDVDQNDR 1074
            :|.     ..|..|.|..|.|.:.       :|||..:...||.::|:
Yeast   890 LKKVAENMDADEDNDDDNDNEHINKTNNCDDNNDSKETVNLDVTEDDK 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	MobB_LATS1	644..718	CDD:439273	16/83 (19%)
		STKc_LATS	717..1078	CDD:270749	97/413 (23%)
STE20	NP_011856.1	PBD	336..394	CDD:395634	15/88 (17%)
		STKc_PAK	619..872	CDD:270789	80/329 (24%)