Protein Alignment wts and PKH1

DIOPT Version :10

• Sequence 1: NP_733403.1
• Gene: wts / 43651
• FlyBaseID: FBgn0011739
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: NP_010778.3
• Gene: PKH1 / 852101
• SGDID: S000002898
• Length: 766
• Species: Saccharomyces cerevisiae
• Alignment Length: 524
• Identity: 135/524 - (25%)
• Similarity: 237/524 - (45%)
• Gaps: 121/524 - (23%)

  Fly   567 NNNIQISNSNLATTPPIPPAKYNNNSSN------TGANSSGGS------NGSTGTTASSSTS--- 616
            |.::..::..|.:.|.:|.:..:..:..      .|:||..||      .|..|..|.:||:
Yeast     3 NRSLTEADHALLSKPLVPTSAEHTQTQEYPRPFVDGSNSQSGSELQASPQGQFGEKALTSTNRFI 67

  Fly   617 -----CKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQRTYRKN 676
                 ...::|...:....:..:|:..||...:|               :::|:..      ...
Yeast    68 PLANDDPGMQHEMGLDPSMRRRREEWAERGAAKI---------------VKDVVDP------ATG 111

  Fly   677 QLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDT 741
            :|.|.:.|:|:.|                             |...:.:|.|::..|.|.:..|
Yeast   112 ELTKHVVKMGIKD-----------------------------FKFGEQLGDGSYSSVVLATARD- 146

  Fly   742 SNHLYAMKTLRKADVLKRNQVAHVKAERDILAEAD-NNWVVKLYYSFQDKDNLYFVMDYIPGGDL 805
            |...||:|.|.|..::::.:|.:|..|:..|.:.: ...:.||:::|||:.:|||:::|.|.||.
Yeast   147 SGKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKLNGTKGIFKLFFTFQDEASLYFLLEYAPHGDF 211

  Fly   806 MSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRW 870
            :.|:.|.|...|..||:|.:::..||||:|.:|.|||||||:|||:|::..:||||||
Yeast   212 LGLIKKYGSLNETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDKNMKVKLTDFG------- 269

  Fly   871 THNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLER 935
              .:|...|..::: .|....::.|::                    :.|.|||..|::||:|..
Yeast   270 --TAKILPEEPSNT-ADGKPYFDLYAK--------------------SKSFVGTAEYVSPELLND 311

  Fly   936 SGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKV--INWEKTLHIPPQAELSREATDLIRR 998
            :.....||.|:.|.|||:||.|:|||.|.:...|.|||  |.:..|...|      :...||:::
Yeast   312 NYTDSRCDIWAFGCILYQMLAGKPPFKAANEYLTFQKVMKIQYAFTAGFP------QIVKDLVKK 370

  Fly   999 LCA-SADKRLGKSVDEVKSHDFFKGIDFAD--MRKQKAPYIPEIKHPTDTSNFDPVDP-EKLRSN 1059
            |.. ..:.||  ::.::|:|.||..::|.|  :.....|.|...|     .|.:.:.| :|:..:
Yeast   371 LLVRDPNDRL--TIKQIKAHLFFHEVNFEDGSVWDDNPPEIQPYK-----INAEAMKPLQKVSES 428

  Fly  1060 DSTM 1063
            |:|:
Yeast   429 DTTV 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	MobB_LATS1	644..718	CDD:439273	7/73 (10%)
		STKc_LATS	717..1078	CDD:270749	110/354 (31%)
PKH1	NP_010778.3	STKc_PDK1	123..391	CDD:270733	99/335 (30%)