Protein Alignment wts and Lats2

DIOPT Version :10

• Sequence 1: NP_733403.1
• Gene: wts / 43651
• FlyBaseID: FBgn0011739
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: NP_001100737.1
• Gene: Lats2 / 305922
• RGDID: 1305906
• Length: 1042
• Species: Rattus norvegicus
• Alignment Length: 1110
• Identity: 451/1110 - (40%)
• Similarity: 555/1110 - (50%)
• Gaps: 286/1110 - (25%)

  Fly    92 QPGAGSISVSGVGVGVVGVANGRVPKMM---------TALMPNKLIRKPSIERDTASSHYLRCSP 147
            |.|:.||..:...:..:|..:.|..:::         ..|:|..:.|:||.|
  Rat   123 QTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLVPTAVTRRPSFE------------- 174

  Fly   148 ALDSGAGSSRSDSPHSHHTHQPSSRTVG--NPGGNGGFSPSP--------SGFSEVAPPA---PP 199
                |.|.:           .||...:|  |..|.......|        .|.|....||   ||
  Rat   175 ----GTGEA-----------FPSHHQLGGANYEGPAALEEMPRQYLDFLFPGASVHGAPAHQHPP 224

  Fly   200 PRNPTACSAATPPP-------PVPPTSQAYVKRRSPALNNRPPAIAPPTQRGNSPVITQNGLKNP 257
            ....||..|.|..|       .:......|..:|||:..::.|   |.|.  :|....|.|   |
  Rat   225 KGYSTAVDAGTHFPGAHYGRAHLLSEQPGYGVQRSPSFQSKTP---PDTY--SSLAKAQGG---P 281

  Fly   258 QQQLTQQLKSLNLYPGGGS---------GAVVEPPPPYLIQGGAGGAAPPPPPPSYTASMQSRQS 313
            ...||        :|....         .|.|....|..:.|..|        |::|.     .|
  Rat   282 PASLT--------FPAHAGLYTTSHHKPAAAVPGAHPLHVLGTRG--------PTFTG-----DS 325

  Fly   314 PTQSQQSDYRKSPSSGIYSATSAGSPSPITVSLPPAPLAKPQPRVYQARSQQPIIMQSVKSTQVQ 378
            .||:..:..|.|.::.:|   ..|||.|    .|.||||:          :..:..||::::
  Rat   326 STQAVLAPSRNSLNNDLY---ELGSPVP----WPAAPLAR----------RDSLQKQSLEAS--- 370

  Fly   379 KPVL---------QTAVAPQSPSSASASNSPVHVLAAPPSYPQKSAAVVQQQQQAAAAAHQQQHQ 434
            :|.:         .:..:||...|..|.|:...|.||...:|.||..|::.:.|.|..
  Rat   371 RPHVAFRAGPSRTNSFSSPQPEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVG------- 428

  Fly   435 HQQSKP---PTPTTPPLV-GLNSKPNCLEPPSYAKSMQAKAATVVQQQQQQQQQQQQVQQQQVQQ 495
              .|.|   |.||.|... ||.||.....||..
  Rat   429 --PSHPAWVPAPTAPAAAEGLESKEGSAGPPPL-------------------------------- 459

  Fly   496 QQQQQQQQLQALRVLQAQAQRERDQRERDQRERERDQQKLANGNPGRQMLPPPPYQSNNNNNSEI 560
                                      :.|....||             ..|||||..:
  Rat   460 --------------------------DMDFGGSER-------------RCPPPPYPKH------- 478

  Fly   561 KPPSCNNNNIQISNSNLATTPPIPPAKYNNNSSN-----TGANSS--GGS------NGSTGTTAS 612
                                 .:.|:|....|:.     ||...|  ||:      .|..|....
  Rat   479 ---------------------LLLPSKSEQYSAGLDRLCTGVEQSLRGGTEQDRNDKGHKGAKGD 522

  Fly   613 SSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQRTYRKNQ 677
            .:...||....||:|.||   ..::||::|.||:.|||.|||||||||:|||||:|:|:..|:.|
  Rat   523 KAGRDKKQIQTSPVPVRK---NSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVSRRLQ 584

  Fly   678 LEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTS 742
            ||:||.|.||.:..|.:|||:|.||||||.||||||||||||||:|.:|:||||||.|..|:||
  Rat   585 LEQEMAKAGLCETEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDT- 648

  Fly   743 NHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMS 807
            :.|||||||||.|||.|||||||||||||||||||.|||||||||||||:||||||||||||:||
  Rat   649 HALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMS 713

  Fly   808 LLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTH 872
            |||::.:|.|.||||||||:|.|::||||||||||||||||||||.|||||||||||||||||||
  Rat   714 LLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTH 778

  Fly   873 NSKYYQENGNHSRQDSMEP---WEEYS--ENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEV 932
            ||||||: |||.|||||||   |::.|  ..|.:...||:|..:.|||.||||||||||||||||
  Rat   779 NSKYYQK-GNHIRQDSMEPGDLWDDVSNCRCGDRLKTLEQRAQKQHQRCLAHSLVGTPNYIAPEV 842

  Fly   933 LERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIR 997
            |.|.|||||||:|||||||:|||||||||||.:|.|||.||||||.|||||.|.:||.||.|||.
  Rat   843 LLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPTQVKLSAEARDLIT 907

  Fly   998 RLCASADKRLGK-SVDEVKSHDFFKGIDFA-DMRKQKAPYIPEIKHPTDTSNFDPVDPEK---LR 1057
            :||.:||.|||: ..|::|:|.||..|||: |:|||.|||:|.|.||.|||||||||.|.   ..
  Rat   908 KLCCAADCRLGRDGADDLKAHPFFSTIDFSRDIRKQPAPYVPTISHPMDTSNFDPVDEESPWHEA 972

  Fly  1058 SNDSTMSSGDDVDQNDR-TFHGFFEFTFRRFFDD----------KQPPDMTDDQ----------- 1100
            |.:|..:.......|.: ..|.|:||||||||||          .:|.:..|..
  Rat   973 SGESAKAWDTLASPNSKHPEHAFYEFTFRRFFDDNGYPFRCPKPSEPAESADPGDAELGGAVEGC 1037

  Fly  1101 APVYV 1105
            .||||
  Rat  1038 QPVYV 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	MobB_LATS1	644..718	CDD:439273	50/73 (68%)
		STKc_LATS	717..1078	CDD:270749	259/371 (70%)
Lats2	NP_001100737.1	UBA_LATS2	101..141	CDD:270581	4/17 (24%)
		PHA03247	<143..490	CDD:223021	101/531 (19%)
		MobB_LATS2	543..625	CDD:439272	53/81 (65%)
		Protein Kinases, catalytic domain	624..1004	CDD:473864	267/381 (70%)