Protein Alignment wts and LATS2

DIOPT Version :10

• Sequence 1: NP_733403.1
• Gene: wts / 43651
• FlyBaseID: FBgn0011739
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: XP_054230417.1
• Gene: LATS2 / 26524
• HGNCID: 6515
• Length: 1090
• Species: Homo sapiens
• Alignment Length: 1250
• Identity: 480/1250 - (38%)
• Similarity: 583/1250 - (46%)
• Gaps: 344/1250 - (27%)

  Fly     3 PAGEKRGGRPNDKYTAEALESIKQDLTRFEVQNNHRNNQNYTPLRYTATNGRNDALTPDYHHAKQ 67
            |||      ||...:.:|.....:|.||.:.|           :|.|...|.......:..::..
Human    38 PAG------PNSDTSLDAKVLGSKDATRQQQQ-----------MRATPKFGPYQKALREIRYSLL 85

  Fly    68 PMEPPPSASPAPDVVIPPPPAIVG-------------QPGAGSISVSGVGVGVVGVANGRVPKMM 119
            |.......|.|.:|.......:|.             |.|:.||..:...:..:|..:.|..:::
Human    86 PFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIV 150

  Fly   120 ---------TALMPNKLIRKPSIE---RDTASSHYLRCSP------------ALDS--------- 151
                     ..|||..:.|:||.|   ...||.|.|..:|            ||:.
Human   151 RVIKQTSPGKGLMPTPVTRRPSFEGTGDSFASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYL 215

  Fly   152 --GAGSSRSDSPHSH---------------------HTHQPSSRTVGNPGGNGGFSPSPSGFSEV 193
              |.|.......|.|                     |..:|.....|.|.|. |...|||..|:.
Human   216 FPGVGPHGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGRPHLLVPGEPLGY-GVQRSPSFQSKT 279

  Fly   194 AP--------PAPPPRNPTACSAATPPP------PVPPTSQA-YVKRRSPALNNRPPAIAPPTQR 243
            .|        |......|.....|.|||      |.|...|| .|..:...|.:|....|
Human   280 PPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAGPVAHQLHVLGSRSQVFA----- 339

  Fly   244 GNSPVITQNGLKNPQQQLTQQLKSLN--LYPGGGSGAVVEPPPPYLIQGGA----GGAAPPP--- 299
            .:||         ||..||....|||  ||. ..|.:|.:.|...|.:..:    |..|||.
Human   340 SDSP---------PQSLLTPSRNSLNVDLYE-LSSTSVQQWPAATLARRDSLQKPGLEAPPRAHV 394

  Fly   300 ------PPPSYTASMQSRQSPTQSQQSDYRKSPSSGIYSATSAGSPSPITVSLPPAPLAKPQPRV 358
                  |.||.|.|..|.|             |..|.........|:|.||:...|
Human   395 AFRPDCPVPSRTNSFNSHQ-------------PRPGPPGKAEPSLPAPNTVTAVTA--------- 437

  Fly   359 YQARSQQPIIMQSVKSTQVQKPVLQTAVAPQSPSSASASNSPVHVLAAPPSYPQKSAAVVQQQQQ 423
                   ..|:..|||.:|.:|..||||.|..|:...|        .||...|
Human   438 -------AHILHPVKSVRVLRPEPQTAVGPSHPAWVPA--------PAPAPAP------------ 475

  Fly   424 AAAAAHQQQHQHQQSKPPTPTTPPLVGLNSKPNCLEPPSYAKSMQAKAATVVQQQQQQQQQQQQV 488
                            .|.| .|...||::|      ..:|.::....|..:..:.
Human   476 ----------------APAP-APAAEGLDAK------EEHALALGGAGAFPLDVEY--------- 508

  Fly   489 QQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRERDQRERERDQQKLANGNPGRQMLPPPPYQSN 553
                                                             |.|.|: .|||||..:
Human   509 -------------------------------------------------GGPDRR-CPPPPYPKH 523

  Fly   554 --NNNNSEIKPPSCNNNNIQISNSNLATTPPIPPAKYNNNSSNTGANSS---------GGSNGST 607
              ..:.||                           :|:.:|...|...|         ||.....
Human   524 LLLRSKSE---------------------------QYDLDSLCAGMEQSLRAGPNEPEGGDKSRK 561

  Fly   608 GTTASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQRT 672
            ..........||....||:|.||   ..::||::|.||:.|||.|||||||||:|||||:|:|:.
Human   562 SAKGDKGGKDKKQIQTSPVPVRK---NSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKV 623

  Fly   673 YRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVS 737
            .|:.|||:||.|.||.:..|.:|||:|.||||||.||||||||||||||:|.:|:||||||.|..
Human   624 NRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLAC 688

  Fly   738 KIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPG 802
            |:|| :.|||||||||.|||.|||||||||||||||||||.|||||||||||||:||||||||||
Human   689 KVDT-HALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPG 752

  Fly   803 GDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTG 867
            ||:|||||::.:|.|.||||||||:|.|::||||||||||||||||||||.||||||||||||||
Human   753 GDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTG 817

  Fly   868 FRWTHNSKYYQENGNHSRQDSMEP---WEEYS--ENGPKPTVLERRRMRDHQRVLAHSLVGTPNY 927
            |||||||||||: |:|.|||||||   |::.|  ..|.:...||:|..:.|||.|||||||||||
Human   818 FRWTHNSKYYQK-GSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNY 881

  Fly   928 IAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREA 992
            ||||||.|.|||||||:|||||||:|||||||||||.:|.|||.||||||.|||||.|.:||.||
Human   882 IAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEA 946

  Fly   993 TDLIRRLCASADKRLGKS-VDEVKSHDFFKGIDF-ADMRKQKAPYIPEIKHPTDTSNFDPVDPEK 1055
            .|||.:||.|||.|||:: .|::|:|.||..||| :|:|||.|||:|.|.||.||||||||| |:
Human   947 RDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVD-EE 1010

  Fly  1056 LRSNDSTMSSGDDVD-----QNDRTFHGFFEFTFRRFFDDKQPP--------------------- 1094
            ...||::..|....|     .|....|.|:||||||||||...|
Human  1011 SPWNDASEGSTKAWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLES 1075

  Fly  1095 ----DMTDDQAPVYV 1105
                |.|:...||||
Human  1076 SDLVDQTEGCQPVYV 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	MobB_LATS1	644..718	CDD:439273	50/73 (68%)
		STKc_LATS	717..1078	CDD:270749	261/372 (70%)
LATS2	XP_054230417.1	UBA_LATS2	101..141	CDD:270581	5/39 (13%)
		PHA03247	<143..521	CDD:223021	108/524 (21%)
		MobB_LATS2	587..669	CDD:439272	53/81 (65%)
		STKc_LATS2	668..1048	CDD:173715	269/382 (70%)