Protein Alignment wts and lats1

DIOPT Version :10

• Sequence 1: NP_733403.1
• Gene: wts / 43651
• FlyBaseID: FBgn0011739
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: XP_017949762.1
• Gene: lats1 / 100145677
• XenbaseID: XB-GENE-959763
• Length: 1117
• Species: Xenopus tropicalis
• Alignment Length: 1210
• Identity: 487/1210 - (40%)
• Similarity: 600/1210 - (49%)
• Gaps: 310/1210 - (25%)

  Fly     4 AGEKRGGRPNDKYTA--EALESIKQDLTRF-EVQ------NNHRNNQNYTPLRYTA--------- 50
            |.:.|.||...|:..  :||..|:..|..| .|.      |:..|.|.:..|:...
 Frog    57 AEDSRQGRSTTKFGTYHKALAEIRNSLLPFANVSGSSPRGNSEINRQMFHDLQQAGFDEDMVIRA 121

  Fly    51 ---TNGRNDALTPDY----HHAKQPMEPPPSASPAPDVVIPP----PPAIVGQPGAGSISVSGVG 104
               ||.|:.....:|    ::.:...||..:|......:.||    .|....|...||
 Frog   122 LQQTNSRSIEAAIEYISRMNYPEMYQEPHIAARTLNASIKPPGNMQNPVNRRQSWKGS------- 179

  Fly   105 VGVVGVANGRVPKMMTALMPNKLIRKPSIERDTASSHYLRCSPALDSGAGSSRSDSPHSHHTHQP 169
                          ..:|:|.:|:                 ||..|:...:|.:.|
 Frog   180 --------------KESLIPQRLV-----------------SPLSDNVVYASENSS--------- 204

  Fly   170 SSRTVGNPGGNGGFS---------------PSPSGFSEVAPPAPPPRNPTACSAATPPP---PVP 216
            |...:|.|....|.|               |.|.....|.||.||||      ..||||   ..|
 Frog   205 SQTEMGRPLSGSGLSAFAQALPVNGQRVNPPPPPQMRSVTPPPPPPR------GQTPPPKGTTPP 263

  Fly   217 PTS-QAYVKRRS-------PALNNRP--------PAIAPPTQR-----------GNSPVITQ--- 251
            ||| :...||.|       |.:|:.|        |..:..||.           |..|:|.|
 Frog   264 PTSWEPQPKRYSGNMEFLIPRMNSIPSGSRQEGFPVSSVNTQSQGQRAINSVPVGRQPIIMQTSN 328

  Fly   252 ---------NGLKN---PQQQLTQQLKSLNLYPGGGSGAVVEPPPPYLIQGGAGGAAPPPPPPSY 304
                     :|::|   ..:.:|.|        |||:....:|||||.|..|         |.:.
 Frog   329 NSKFAYSGRSGMQNGNGSSEFITNQ--------GGGNIGGRQPPPPYSIPNG---------PNTT 376

  Fly   305 TASMQSRQ-SPTQSQQSDYRKSPSSGIYSATSAGSPSPITVSLPPAPLAKPQPRVYQARSQQ--P 366
            |..:||.. .|..|...:....|.|.:.|..::.:.....:|||..|.:.|     ||.|.|  |
 Frog   377 TLQVQSGSGGPLSSNAYNNSNVPPSMLVSNRNSHNLEMYNISLPGHPTSWP-----QASSTQSAP 436

  Fly   367 IIMQSVKSTQVQKPV----LQTAVAPQSPSSASASNSPVHVLAAPPS---YPQKSAAVVQQQQQA 424
            .....:.|.|...||    ....||.....|.:...|...|.|..||   .|.||..|::.:.|.
 Frog   437 GSNHDMLSWQTNIPVRSNSFNNPVASWQALSTNTQTSATTVTAVTPSPIQQPVKSIRVLKPELQT 501

  Fly   425 AAAAHQQQHQHQQSKPPTPTTPPLVGLNSKPNCL-EPPSYAKSMQAKAATVVQQQQQQQQQQQQV 488
            |.|               ||.|..:..|.:|... |..|:..|.|...|...|.
 Frog   502 ALA---------------PTHPTWMTPNVQPGPFQEGVSHNTSAQLAEAPNYQG----------- 540

  Fly   489 QQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRERDQRERERDQQKLANGNPGRQMLPPPPYQSN 553
                                                                     |||||..:
 Frog   541 ---------------------------------------------------------PPPPYPKH 548

  Fly   554 --NNNNSEIKPPSCNNNNIQISNSNLATTPPIPPAKYNNNSSNTGANSSGGSNGSTGTTASSSTS 616
              ..|.:..:|      .::.|..:.|........:...|:..|           ||.|.
 Frog   549 LLQQNTTVYEP------GLKSSKEDAAGVSTCTQEEMEKNTEPT-----------TGITE----- 591

  Fly   617 CKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQRTYRKNQLEKE 681
             ||....||:|.|:   .:::|||:|.:|:.|||||||||||||:||::||:.||.:||.|||.|
 Frog   592 -KKQITTSPVPVRR---NKRDEERRESQIQSYSPQAFKFFMEQHVENILKSHHQRLHRKKQLENE 652

  Fly   682 MHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLY 746
            |.:|||..:.|.:|||||.||||||||||||||:||||||:|.:|:||||||.|..|.|| |.||
 Frog   653 MMRVGLSQEAQDQMRKMLCQKESNYIRLKRAKMEKSMFVKIKTLGIGAFGEVCLARKTDT-NALY 716

  Fly   747 AMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIK 811
            |||||||.|||.|||||||||||||||||||.|||:||||||||||||||||||||||:|||||:
 Frog   717 AMKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIR 781

  Fly   812 LGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKY 876
            :|:|.|:||||||||:||||:|||||.||||||||||||||||||||||||||||||||||:|||
 Frog   782 MGVFPEDLARFYIAELTCAVESVHKMDFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKY 846

  Fly   877 YQENGNHSRQDSMEPWEEYSEN-----GPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERS 936
            || :|:|.|||||:...|:.:.     |.:...||.|..|.|||.|||||||||||||||||.|:
 Frog   847 YQ-SGDHLRQDSMDFSNEWGDPANCRCGDRLKPLEWRAARQHQRCLAHSLVGTPNYIAPEVLLRT 910

  Fly   937 GYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLCA 1001
            |||||||:|||||||||||||||||||.||:|||.|||.|:.|||||.||:||.||:|||.:||.
 Frog   911 GYTQLCDWWSVGVILYEMLVGQPPFLAQSPVETQMKVIKWQTTLHIPAQAKLSPEASDLIVKLCR 975

  Fly  1002 SADKRLGKS-VDEVKSHDFFKGIDF-ADMRKQKAPYIPEIKHPTDTSNFDPVDPEKLRSNDSTMS 1064
            ..:.||||: |||:|.|.|||.||| :|:|:|.|||.|.|.||||||||||||||||.:::.
 Frog   976 GPEDRLGKNGVDEIKVHPFFKNIDFSSDLRQQPAPYTPTITHPTDTSNFDPVDPEKLWNDED--- 1037

  Fly  1065 SGDDVDQND----------RTFHGFFEFTFRRFFDDKQPP 1094
              .|.::||          ...|.|:||||||||||...|
 Frog  1038 --KDGNKNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGHP 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	MobB_LATS1	644..718	CDD:439273	51/73 (70%)
		STKc_LATS	717..1078	CDD:270749	265/377 (70%)
lats1	XP_017949762.1	UBA_LATS1	102..142	CDD:270580	6/39 (15%)
		MobB_LATS1	614..689	CDD:439273	51/74 (69%)
		STKc_LATS1	688..1069	CDD:270775	273/387 (71%)