Protein Alignment wts and lats2

DIOPT Version :10

• Sequence 1: NP_733403.1
• Gene: wts / 43651
• FlyBaseID: FBgn0011739
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: XP_012811721.1
• Gene: lats2 / 100124721
• XenbaseID: XB-GENE-994907
• Length: 1117
• Species: Xenopus tropicalis
• Alignment Length: 1104
• Identity: 448/1104 - (40%)
• Similarity: 576/1104 - (52%)
• Gaps: 200/1104 - (18%)

  Fly    92 QPGAGSISVSGVGVGVVGV---ANGRVPKMMTALMPNKLIRKPSIERDTASSHYLRCSPALDSGA 153
            |.|:.||..:...:..:|.   .|.::.:::....|.|:....|:      ||.....
 Frog   124 QTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKVTPPNSV------SHRANFE------- 175

  Fly   154 GSSRSDSPHSHHTHQPSSRTVGNPG----GNGGFSPSPSGFSEVAPPAPPPRNPTACSAATPP-- 212
            ||:.:.||:    |..::.....||    |....|..|..:.:....:|.|......|....|
 Frog   176 GSNETFSPY----HPVNNAAYEGPGFAAEGANVLSEVPRQYMDYLLSSPQPATLNGPSQRPLPVV 236

  Fly   213 ----PPVPPTSQAYVKRRSPAL-------NNRPPAIAPPTQRGNSPVITQNGLK---NPQQQLTQ 263
                .||....:.||.....|:       :|.|..........:||..::..:.   :|.....|
 Frog   237 GAHNSPVSHQQKGYVTNAESAVINYVIGSHNSPGLPIQTPHASSSPHYSRQHMMVQGDPMGYSVQ 301

  Fly   264 QLKSL--NLYPGGGSGAVVEPPPPYLIQGGAGGAAPP------PPPPSYTASMQSRQSPTQSQQS 320
            :..|.  .:...||...:.:..|.:.......|...|      ..|||:...:.||.||..::.|
 Frog   302 RTPSFQNKMQQDGGYVNIPQTSPGHAYTQAPSGLYMPHTHHKQTSPPSHQMHVISRGSPYGNEFS 366

  Fly   321 D--------YRKSPSSGIYSATSAGSPS-PITVSLP-PAPLAKPQPRV-YQARSQQPIIMQSVKS 374
            |        .|.|.:..:|...:|...| |...||. |...:.|:..| ::..||.|....|..:
 Frog   367 DTPQALLTPSRNSLNMDLYDIGNAWQNSQPCRDSLQGPGLDSSPRQHVSFRPDSQVPSRTNSFNN 431

  Fly   375 TQVQKPVLQTAVAPQSP-SSASASNSPVHVLAAPPSYPQKSAAVVQQQQQAAAAAHQQQHQHQQS 438
            .|.||.|:.....|..| ||.:|.|:...|.:.....|.||..|.:.:.|.|
 Frog   432 HQQQKQVVMRQTPPNKPDSSMTAPNTVTTVTSTHILQPVKSMRVARPEPQTA------------- 483

  Fly   439 KPPTPTTPPLVGLNSKPNCLEPPSYAKSMQAKAATVVQQQQQQQQQQQQVQQQQVQQQQQQQQQQ 503
                      ||          ||:...:.|:|              |:::.|:|:..:......
 Frog   484 ----------VG----------PSHPSWLAAQA--------------QKLETQKVEMVEPHTSSM 514

  Fly   504 LQALRVLQAQAQRERDQRERDQRERERDQQKLANGNPGRQMLPPPPYQ-----SNNNNNSEIKPP 563
            ..|...........:|.|                       .|||||.     .||....|:. .
 Frog   515 GAANAYGMDVGYGNQDMR-----------------------FPPPPYPKHLLLQNNPEQHELN-A 555

  Fly   564 SCN--NNNIQISNSNLATTPPIPPAKYNNNSSNTGANSSGGSNGSTGTTASSSTSCKKIKHASPI 626
            .|.  :.|:::|.:     .|..|....|........|      .|.....|....|:|: .||:
 Frog   556 LCKGMDQNLRVSEN-----VPCGPVDEANGEPKPSKVS------KTPKVVKSGKDKKQIQ-TSPV 608

  Fly   627 PERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQRTYRKNQLEKEMHKVGLPDQT 691
            |.||   ..::||::|.||:.|||.|:||:||||:|||:|:|:|:..|:.|||:||.:.||.:..
 Frog   609 PVRK---NSRDEEKRESRIKSYSPFAYKFYMEQHVENVLKTYQQKINRRLQLEQEMAEAGLCEAI 670

  Fly   692 QIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADV 756
            |.:|||:|.||||||.||||||||||:|||:|.:|:||||||.|.||:|| ..|||||||||.||
 Frog   671 QEQMRKILYQKESNYNRLKRAKMDKSLFVKIKTLGIGAFGEVCLASKVDT-KALYAMKTLRKKDV 734

  Fly   757 LKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEELAR 821
            |.|||||||||||||||||||.|||||||||||||:||||||||||||:|||||::.:|.|.|||
 Frog   735 LNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLAR 799

  Fly   822 FYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQ 886
            |||||:|.|::||||||||||||||||||||.|||||||||||||||||||||||||: |||:||
 Frog   800 FYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQK-GNHARQ 863

  Fly   887 DSMEP---WEEYS--ENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERSGYTQLCDYWS 946
            |||||   |::.|  ..|.:...||:|..|.|.|.|||||||||||||||||.|.|||||||:||
 Frog   864 DSMEPSELWDDVSNCRCGDRLKTLEQRAKRQHHRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWS 928

  Fly   947 VGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLCASADKRLGKS- 1010
            |||||:|||||||||||::|.|||.|||:||.|||||.|..||.|||:||..||..|:.|||::
 Frog   929 VGVILFEMLVGQPPFLASNPTETQLKVIHWENTLHIPSQINLSPEATNLITALCCGAEDRLGRNG 993

  Fly  1011 VDEVKSHDFFKGIDF-ADMRKQKAPYIPEIKHPTDTSNFDPVDPEK--LRSNDST------MSSG 1066
            .||:|:|.||..:|| :|:|.|.|||:|:|.||.||||||||:.|.  ..|.|||      ||||
 Frog   994 PDEIKAHPFFISMDFSSDIRHQPAPYVPKISHPMDTSNFDPVEEENPCNDSGDSTVTWDTLMSSG 1058

  Fly  1067 DDVDQNDRTFHGFFEFTFRRFFDDKQPP--------------DMTDDQ-----------APVYV 1105
                 |..|.|.|:||||||||||...|              :.|:::           .||||
 Frog  1059 -----NKHTEHAFYEFTFRRFFDDHGYPFRYPKPSKLETSSCEETEEEDKNASRESEGCQPVYV 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	MobB_LATS1	644..718	CDD:439273	46/73 (63%)
		STKc_LATS	717..1078	CDD:270749	262/375 (70%)
lats2	XP_012811721.1	UBA_LATS2	102..142	CDD:270581	4/17 (24%)
		MobB_LATS2	615..697	CDD:439272	49/81 (60%)
		Protein Kinases, catalytic domain	696..1075	CDD:473864	270/385 (70%)