DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15543 and Ak8

DIOPT Version :9

Sequence 1:	NP_001287617.1	Gene:	CG15543 / 43647	FlyBaseID:	FBgn0039799	Length:	290	Species:	Drosophila melanogaster
Sequence 2:	NP_001004266.1	Gene:	Ak8 / 311833	RGDID:	1303144	Length:	479	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	77/352 - (21%)
Similarity:	132/352 - (37%)	Gaps:	117/352 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSPTDFDRSMLVE--------------YSAAFMYYIEKHKLMEVMSRL-----LAEISVADGVT 46
            :|:|.    |:|:|              |...|.:..|    :|:.:||     ::||..|..:.
  Rat   164 LSAPD----SVLIERNVGKRIDPVTGEIYHTTFDWPPE----LEIQNRLIQPEGISEIDTAKKLL 220

  Fly    47 DVRRWMGENITRIGVEIYTK----------SMDAFHRGV----RGDFYQLPRSFYHRIVLHGKPG 97
            :..|    :|.|| :..|.|          .:|.|::.:    .|.....|  |..:::|.|..|
  Rat   221 EYHR----HIIRI-LPSYPKILKTISSDQPCVDVFYQALTYVQSGHRCNAP--FTPKVLLCGPMG 278

  Fly    98 SGRRSLAYVLAQRWNLLILDADVLAYHSINKQDQDEPSRLLQEAIEKDCVYKRSQAVGNLIE--- 159
            .|::..|.:|:|::.|:.:..                .:||:||:..:      .::|:|||
  Rat   279 CGKKLQAALLSQKYGLVNISC----------------GQLLKEAMAAE------SSLGDLIEPFF 321

  Fly   160 ----------------NRLLQEDALHRGWILINYPNNKCEAEELFEGFTVPPNRFVFLQI--DER 206
                            .||.|:|.:.:||:|..:|.:..:| .|.......|||..||.:  |..
  Rat   322 EKRMTVPDSIITRVLTERLKQQDCIQKGWVLHGFPRDLDQA-RLLNSMGYSPNRVFFLNVPLDSI 385

  Fly   207 LARMRILLNS----------YSPGPQAHV------------SFVDRQMAQFRKSEPALSSYLSQR 249
            |.|:.:....          |.|.|...|            .::..|...|.::...|..|. .|
  Rat   386 LERLTLRRTDPVTGERFHLMYKPPPTIEVQARLLQNPKDSEEYIKLQTDLFYRNSGDLEQYY-DR 449

  Fly   250 REVVYVDASP--CFEQVKCGIISELTK 274
            ..:|..|..|  .||.::.|||:.|.:
  Rat   450 AIIVNGDQDPYTVFEYIESGIINPLPR 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15543	NP_001287617.1	NK	89..>213	CDD:302627	34/144 (24%)
Ak8	NP_001004266.1	Adenylate kinase 1. /evidence=ECO:0000250\|UniProtKB:Q96MA6	58..258		22/106 (21%)
		adk	59..258	CDD:273569	22/106 (21%)
		ADK	59..249	CDD:238713	20/97 (21%)
		NMP 1. /evidence=ECO:0000250\|UniProtKB:P69441	87..113
		LID 1. /evidence=ECO:0000250\|UniProtKB:P69441	177..206		6/32 (19%)
		Adenylate kinase 2. /evidence=ECO:0000250\|UniProtKB:Q96MA6	269..471		49/225 (22%)
		adk	270..468	CDD:273569	48/221 (22%)
		ADK	270..462	CDD:238713	46/215 (21%)
		NMP 2. /evidence=ECO:0000250\|UniProtKB:P69441	298..327		8/50 (16%)
		LID 2. /evidence=ECO:0000250\|UniProtKB:P69441	391..424		4/32 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870