DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31371 and p4ha2

DIOPT Version :9

Sequence 1:	NP_733375.2	Gene:	CG31371 / 43626	FlyBaseID:	FBgn0051371	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	XP_005173949.1	Gene:	p4ha2 / 373132	ZFINID:	ZDB-GENE-030827-1	Length:	542	Species:	Danio rerio

Alignment Length:	537	Identity:	135/537 - (25%)
Similarity:	233/537 - (43%)	Gaps:	99/537 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFLLVESVAGANFARGE-----EQLQALLDTETQLIDGLRDYIERLERQLEEIRRETSAIEEI-H 71
            |..|:.:::.::..|.|     .|:..|:.||.:|:..|::||:..|::||.:|...:.:::: .
Zfish     5 LVFLLSTLSFSSPTRAEIFTSIGQMTNLIFTERELVQSLKEYIQAEEQKLETVRSWANKLDKLTR 69

  Fly    72 SQVDSVEEYMGNPLNVFGILKRFESVWPGLEQKANATLEMVFGERLSDRQLTLPSEEDYEESLNH 136
            :.....|.::.:|:|.:.::||..:.|..||..........|...:|..:...|.|||.:.:...
Zfish    70 TSTSDPEGFLAHPVNAYKLMKRLNTEWSELESLVLQDPSDGFISNMSVHRQYFPDEEDEKGAAKA 134

  Fly   137 LLHLQSVYELDSNSLSLGVV------NGFKLGSSMSWGDCLEVAR----KSDFPVARFWLESALE 191
            ||.||..|:||:.|.|.|.:      :|.:..:.::..||.::.:    .:|:..:..|::.:|.
Zfish   135 LLRLQDTYKLDAESFSKGKLPGQRQHSGVRYNALLTVDDCFDMGKMAYNDNDYYHSVLWMQQSLR 199

  Fly   192 KLPSASENSTESQRERESGRVHILEATLNIEYRAGELSRALATAEELLLLLPMNQGIQKAKRKIE 256
            ::.|..|..|.        :..:|:......|:.|:|.||:.....||.:.|.:|......|..|
Zfish   200 QMDSGEEAKTP--------KADVLDYLSYSVYQMGDLPRAIELTRRLLAIDPSHQRAGGNLRYFE 256

  Fly   257 KAMAKKELPKGRGQKSKA-KKQISKST---------EQLLIEEICRGAKQQVTT--GSRFNHCQL 309
            :.::|:....|:.|...| ::.|...|         |:...|.:|||...::||  .||......
Zfish   257 RLLSKELQDSGQTQPEPADERPIQLDTYQRPKDYLPEREAYEALCRGEGVKMTTKRQSRLFCRYR 321

  Fly   310 DGS-SPWLLLQPSRLEPVSSDPYIVLHHDVLTPKESNELLQLIDEEEDTKGVSYQSLKLSKLAQK 373
            ||: :|.|||:|.:.|.....|:||...:.|    |:|.:|.|.|      ::...|..:.:...
Zfish   322 DGNRNPRLLLKPMKEEDEWDSPHIVRFLEAL----SDEEIQKIKE------IATPKLARATVRDP 376

  Fly   374 KLG-------RISRLLGLEILELDPWTGRRHGH-EHITKLE-HSSELKHVA-------------- 415
            |.|       |:|:...|| .|.||...|.:.. |.||.|. .::||..||
Zfish   377 KTGVLTVAHYRVSKSAWLE-GEDDPVIARVNQRIEDITGLTVDTAELLQVANYGVGGQYEPHFDF 440

  Fly   416 ----------------------RLMLNLQAPGMGGAVVFPQLELAVNVPRGSLLHWRTRFAGGSS 458
                                  ..|.:::|   |||.|||....:|...:|:.:.|...|..|
Zfish   441 SRKDEPDAFKSLGTGNRVATYLNYMSDVEA---GGATVFPDFGASVWPRKGTAVFWYNLFRSG-- 500

  Fly   459 SEWDYRSGQAICPVLLG 475
             |.|||:..|.||||:|
Zfish   501 -EGDYRTRHAACPVLVG 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31371	NP_733375.2	P4Ha_N	30..156	CDD:285528	36/126 (29%)
p4ha2	XP_005173949.1	P4Ha_N	25..154	CDD:285528	36/128 (28%)
p4ha2	XP_005173949.1	P4Hc	353..526	CDD:214780	47/177 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391515at2759
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920