Protein Alignment CDase and ASAH2

DIOPT Version :10

• Sequence 1: NP_651797.1
• Gene: CDase / 43618
• FlyBaseID: FBgn0039774
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_063946.2
• Gene: ASAH2 / 56624
• HGNCID: 18860
• Length: 780
• Species: Homo sapiens
• Alignment Length: 697
• Identity: 307/697 - (44%)
• Similarity: 425/697 - (60%)
• Gaps: 41/697 - (5%)

  Fly    25 YKVGVGRADITGPPVEINFMGYANIKQVGRGIHTRVFARAFVVEDEKG-NRVAFVSADAGMMGYG 88
            |.:||||||.||...:||.|||....|..:||.||:::|||::.:..| ||..|||.|.||:...
Human   102 YHIGVGRADCTGQVADINLMGYGKSGQNAQGILTRLYSRAFIMAEPDGSNRTVFVSIDIGMVSQR 166

  Fly    89 LKREVIKRLQARYGNIYHNDNVAISGTHTHGAPGGFLMHLLYDISILGFVPQTFEVMAQGLYLCI 153
            |:.||:.|||::||::|..|||.:||||||..|.|:..:.::.|:..||..|||:.|..|:...|
Human   167 LRLEVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHMVTGILKSI 231

  Fly   154 KRATDNLVDGRILLSKTTVLNVNINRSPSSYLRNPAEERAQYEHDTDKTLTQLRFVDLENNLLGA 218
            ..|..|:..|:|.::|..|..|.|||||.|||:||..|||:|..:|||.:..|:.|||..:.||.
Human   232 DIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIVLKMVDLNGDDLGL 296

  Fly   219 FNWYAVHATSMNNTNRLVTSDNVGYAALLLEKEYNPNKMPGKGKFVGAFCSSNLGDVSPNIMGPK 283
            .:|:|:|..||||:|.||.|||||||:.|||:|.|...:||:|.||.||.|||||||||||:||:
Human   297 ISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVAAFASSNLGDVSPNILGPR 361

  Fly   284 CSISGNECDLLTSRCPT-GEGDCFASGPGKDMFESTQILGQRLADAALGLLNEQSQESTAREVTG 347
            |..:|..||...|.||. |...|.|.|||:|||:||||:|:.:...|     ::...|.::||||
Human   362 CINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRAMYQRA-----KELYASASQEVTG 421

  Fly   348 DVRFIHQFVDMPN---YNGSTYNPLSRKVDKIRGCQPAMGYSFAAGTTDGPGAFSFEQGTTTDNP 409
            .:...||:|||.:   :..||:        ..:.|:||:||||||||.||.|..:|.||.|..:|
Human   422 PLASAHQWVDMTDVTVWLNSTH--------ASKTCKPALGYSFAAGTIDGVGGLNFTQGKTEGDP 478

  Fly   410 MWNFVRDFIAAPTQEDIK-CHEPKPILLATGRATFPYEWQPKIVSDQLLKIGDVIIAAVPCEFTT 473
            .|:.:||.|.....|:|| ||:||||||.||..:.|:.|.|.||..|::.:|.:.|.|:|.||||
Human   479 FWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVDVQIITLGSLAITAIPGEFTT 543

  Fly   474 MAGRRLRNQIRAAASAVGGIDTEVIIAGLTNIYTSYTVTPEEYQAQRYEAASTIFGPHTHSIYMD 538
            |:|||||..::|..::.|..:..|:|:||.|:||.|..|.||||||||||||||:||||.|.|:.
Human   544 MSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTYEEYQAQRYEAASTIYGPHTLSAYIQ 608

  Fly   539 VFERLTKAMMRNETV---DAGPSPPYMNDVMLSLNTGVLFDGHPINTDFGYVKSQPNKEYGINET 600
            :|..|.|| :..:||   ..||.||:...:::.|...:: |..|....||.|......||.:.|.
Human   609 LFRNLAKA-IATDTVANLSRGPEPPFFKQLIVPLIPSIV-DRAPKGRTFGDVLQPAKPEYRVGEV 671

  Fly   601 VKVTYISGNPRNNL--FTEKTYFTIER-KINEDRWKVAYTDASWETKMVWHRTNTILGFSEMDIY 662
            .:|.::..||:|::  .|.:|:.|:|: :.....|::...||||||:..||:  .:||.|...:.
Human   672 AEVIFVGANPKNSVQNQTHQTFLTVEKYEATSTSWQIVCNDASWETRFYWHK--GLLGLSNATVE 734

  Fly   663 WDISPQTLPGEYRIRHSGEYK--------YILGGKYPYEGLTHSFTV 701
            |.|.....||.||||:.|..:        .||.    :||.:.:|.|
Human   735 WHIPDTAQPGIYRIRYFGHNRKQDILKPAVILS----FEGTSPAFEV 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDase	NP_651797.1	Ceramidase_alk	25..538	CDD:461415	253/518 (49%)
		Ceramidse_alk_C	540..701	CDD:465340	53/174 (30%)
ASAH2	NP_063946.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	47..90
		Ceramidase_alk	102..608	CDD:461415	253/518 (49%)
		Ceramidse_alk_C	610..777	CDD:465340	53/174 (30%)
		Required for correct folding and localization. /evidence=ECO:0000250|UniProtKB:Q91XT9	770..780		3/8 (38%)