Protein Alignment: CDase and ASAH2

• Sequence 1: NP_001263109.1
• Gene: CDase
• FlyBaseID: FBgn0039774
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_063946.2
• Gene: ASAH2
• HGNCID: 18860
• Length: 780
• Species: Homo sapiens
• Alignment Length: 697
• Identity: 307/698 (44%)
• Similarity: 425/698 (61%)
• Gaps: 41/698 (6%)

  Fly    25 YKVGVGRADITGPPVEINFMGYANIKQVGRGIHTRVFARAFVVEDEKG-NRVAFVSADAGMMGYG 88
            |.:||||||.||...:||.|||....|..:||.||:::|||::.:..| ||..|||.|.||:...
Human   102 YHIGVGRADCTGQVADINLMGYGKSGQNAQGILTRLYSRAFIMAEPDGSNRTVFVSIDIGMVSQR 166

  Fly    89 LKREVIKRLQARYGNIYHNDNVAISGTHTHGAPGGFLMHLLYDISILGFVPQTFEVMAQGLYLCI 153
            |:.||:.|||::||::|..|||.:||||||..|.|:..:.::.|:..||..|||:.|..|:...|
Human   167 LRLEVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHMVTGILKSI 231

  Fly   154 KRATDNLVDGRILLSKTTVLNVNINRSPSSYLRNPAEERAQYEHDTDKTLTQLRFVDLENNLLGA 218
            ..|..|:..|:|.::|..|..|.|||||.|||:||..|||:|..:|||.:..|:.|||..:.||.
Human   232 DIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIVLKMVDLNGDDLGL 296

  Fly   219 FNWYAVHATSMNNTNRLVTSDNVGYAALLLEKEYNPNKMPGKGKFVGAFCSSNLGDVSPNIMGPK 283
            .:|:|:|..||||:|.||.|||||||:.|||:|.|...:||:|.||.||.|||||||||||:||:
Human   297 ISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVAAFASSNLGDVSPNILGPR 361

  Fly   284 CSISGNECDLLTSRCPT-GEGDCFASGPGKDMFESTQILGQRLADAALGLLNEQSQESTAREVTG 347
            |..:|..||...|.||. |...|.|.|||:|||:||||:|:.:...|     ::...|.::||||
Human   362 CINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRAMYQRA-----KELYASASQEVTG 421

  Fly   348 DVRFIHQFVDMPN---YNGSTYNPLSRKVDKIRGCQPAMGYSFAAGTTDGPGAFSFEQGTTTDNP 409
            .:...||:|||.:   :..||:        ..:.|:||:||||||||.||.|..:|.||.|..:|
Human   422 PLASAHQWVDMTDVTVWLNSTH--------ASKTCKPALGYSFAAGTIDGVGGLNFTQGKTEGDP 478

  Fly   410 MWNFVRDFIAAPTQEDIK-CHEPKPILLATGRATFPYEWQPKIVSDQLLKIGDVIIAAVPCEFTT 473
            .|:.:||.|.....|:|| ||:||||||.||..:.|:.|.|.||..|::.:|.:.|.|:|.||||
Human   479 FWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVDVQIITLGSLAITAIPGEFTT 543

  Fly   474 MAGRRLRNQIRAAASAVGGIDTEVIIAGLTNIYTSYTVTPEEYQAQRYEAASTIFGPHTHSIYMD 538
            |:|||||..::|..::.|..:..|:|:||.|:||.|..|.||||||||||||||:||||.|.|:.
Human   544 MSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTYEEYQAQRYEAASTIYGPHTLSAYIQ 608

  Fly   539 VFERLTKAMMRNETV---DAGPSPPYMNDVMLSLNTGVLFDGHPINTDFGYVKSQPNKEYGINET 600
            :|..|.|| :..:||   ..||.||:...:::.|...:: |..|....||.|......||.:.|.
Human   609 LFRNLAKA-IATDTVANLSRGPEPPFFKQLIVPLIPSIV-DRAPKGRTFGDVLQPAKPEYRVGEV 671

  Fly   601 VKVTYISGNPRNNL--FTEKTYFTIER-KINEDRWKVAYTDASWETKMVWHRTNTILGFSEMDIY 662
            .:|.::..||:|::  .|.:|:.|:|: :.....|::...||||||:..||:  .:||.|...:.
Human   672 AEVIFVGANPKNSVQNQTHQTFLTVEKYEATSTSWQIVCNDASWETRFYWHK--GLLGLSNATVE 734

  Fly   663 WDISPQTLPGEYRIRHSGEYK--------YILGGKYPYEGLTHSFTV 701
            |.|.....||.||||:.|..:        .||.    :||.:.:|.|
Human   735 WHIPDTAQPGIYRIRYFGHNRKQDILKPAVILS----FEGTSPAFEV 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDase	NP_001263109.1	PTZ00487	24..701	CDD:240437	306/696 (44%)
		Ceramidase_alk	25..538	CDD:282576	253/519 (49%)
		Ceramidse_alk_C	540..701	CDD:293653	53/175 (30%)
ASAH2	NP_063946.2	PTZ00487	100..778	CDD:240437	307/698 (44%)
		Ceramidase_alk	102..608	CDD:282576	253/519 (49%)
		Ceramidse_alk_C	610..777	CDD:293653	53/175 (30%)
		Required for correct folding and localization. {ECO:0000250|UniProtKB:Q91XT9}	770..780		3/9 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C256963350
eggNOG	1	0.900				E1_KOG2232
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000				H10310
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950		0	Normalized mean entropy	S6313
OMA	1	1.010
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0006479
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900				OOG5_129670
Panther	1	1.100			LDO	PTHR12670
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	9	8.750