DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDase and asah2

DIOPT Version :9

Sequence 1:	NP_001263109.1	Gene:	CDase / 43618	FlyBaseID:	FBgn0039774	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_001007764.1	Gene:	asah2 / 493602	ZFINID:	ZDB-GENE-041112-1	Length:	743	Species:	Danio rerio

Alignment Length:	695	Identity:	302/695 - (43%)
Similarity:	419/695 - (60%)	Gaps:	37/695 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YKVGVGRADITGPPVEINFMGYANIKQVGRGIHTRVFARAFVVEDEKGN-RVAFVSADAGMMGYG 88
            |.:||||||.|||..::..|||||..|..||:|||:|:|||:|:|  || ||.||::|.||:...
Zfish    61 YLIGVGRADCTGPVADLPMMGYANTDQTARGLHTRLFSRAFIVDD--GNKRVVFVTSDIGMVSQR 123

  Fly    89 LKREVIKRLQARYGNIYHNDNVAISGTHTHGAPGGFLMHLLYDISILGFVPQTFEVMAQGLYLCI 153
            |:.||.:.|:.:||::|..|||.:||||||...||:..:.|:.|:..|::..:.:.:..|:...|
Zfish   124 LRLEVFQALKEKYGDLYRQDNVVLSGTHTHSGVGGYFQYTLFMITSKGYIKPSIQAIVSGIVKSI 188

  Fly   154 KRATDNLVDGRILLSKTTVLNVNINRSPSSYLRNPAEERAQYEHDTDKTLTQLRFVDLENNLLGA 218
            ..|..||..|||.::|..|.:.|.||||.||:.||.|||.:||.:|||.:..|:|.||:.:.:|.
Zfish   189 DIAHRNLRPGRIFINKGQVADSNFNRSPHSYMNNPEEERNRYEFNTDKQIVVLKFTDLDGDGIGL 253

  Fly   219 FNWYAVHATSMNNTNRLVTSDNVGYAALLLEKEYNPNKMPG-KGKFVGAFCSSNLGDVSPNIMGP 282
            .:|:|||..|||.|||:|:|||:|||:.:.|:|.|...:|| ||.||..|.||||||.||||.||
Zfish   254 LSWFAVHPVSMNYTNRMVSSDNLGYASYIFEQEKNIGFLPGEKGPFVAGFSSSNLGDSSPNIRGP 318

  Fly   283 KCSISGNECDLLTSRCPT-GEGDCFASGPGKDMFESTQILGQRLADAALGLLNEQSQESTAREVT 346
            .|..:|.:||.:.|.||. |:..|.|.|||:||||||:|:|:.:...|..|..     |..:|:.
Zfish   319 VCVNTGLKCDYINSSCPVGGKKACIAFGPGEDMFESTRIIGENMFKIAKELYG-----SAKQELH 378

  Fly   347 GDVRFIHQFVDMPN----YNGSTYNPLSRKVDKIRGCQPAMGYSFAAGTTDGPGAFSFEQGTTTD 407
            |.|...||:|:|.:    :| ||:..        |.|:||:|:|||||||||.|.|:|.||.|..
Zfish   379 GPVYGAHQWVNMTDETVQFN-STHTG--------RTCKPALGHSFAAGTTDGGGEFNFLQGDTEG 434

  Fly   408 NPMWNFVRDFIAAPTQEDIK-CHEPKPILLATGRATFPYEWQPKIVSDQLLKIGDVIIAAVPCEF 471
            :|.|:.:||.:..|...:.| ||:|||||.:||....|..|.|.||..|::.||.:.:.|||.||
Zfish   435 DPFWDGIRDAVLGPPSNETKACHQPKPILFSTGEMDSPLPWHPAIVDVQIITIGSLAVVAVPGEF 499

  Fly   472 TTMAGRRLRNQIRAAASAVGGI-DTEVIIAGLTNIYTSYTVTPEEYQAQRYEAASTIFGPHTHSI 535
            |||:|||:|..::......... :.||::|||.||||.|..|.||||.||||.|||||||||.|.
Zfish   500 TTMSGRRIREAVKRELEVKEPFTNAEVVVAGLCNIYTHYITTYEEYQIQRYEGASTIFGPHTLSA 564

  Fly   536 YMDVFERLTKAMMRNE--TVDAGPSPPYMN-DVMLSLNTGVLFDGHPINTDFGYVKSQPNKEYGI 597
            |:..:..|.||:....  .:..||.||:.: |.:.:.....:.|..|:.|.||.|..:.|..|.:
Zfish   565 YIQRYRGLAKAIAHGTIGELPKGPEPPFFDEDKLFNQVRDPVADVAPVGTTFGDVLQEVNPVYKV 629

  Fly   598 NETVKVTYISGNPRNN-LFTEKTYFTIERKINE-DRWKVAYTDASWETKMVWHRTNTILGFSEMD 660
            .|...||::|||||:: ...:.|..|:||..|: ..|::.:.||||||:..|  ...:.|.|:..
Zfish   630 GEIASVTFVSGNPRHSGDIRDTTLVTVERFHNDTGSWEIIHNDASWETRFHW--IKGLAGRSQAK 692

  Fly   661 IYWDISPQTL-PGEYRIRHSGEYKYILGGK---YPYEGLTHSFTV 701
            :.|.| |||. .|.|:|::.|.||......   .||.|.:.:|.|
Zfish   693 VEWHI-PQTAQAGTYQIQYFGHYKQTTENTTVITPYVGTSAAFKV 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDase	NP_001263109.1	PTZ00487	24..701	CDD:240437	301/693 (43%)
		Ceramidase_alk	25..538	CDD:282576	247/521 (47%)
		Ceramidse_alk_C	540..701	CDD:293653	54/169 (32%)
asah2	NP_001007764.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..60
		PTZ00487	61..736	CDD:240437	301/693 (43%)
		Ceramidase_alk	61..567	CDD:282576	247/521 (47%)
		Ceramidse_alk_C	569..736	CDD:293653	54/169 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574665
Domainoid	1	1.000	469	1.000	Domainoid score	I435
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10310
Inparanoid	1	1.050	543	1.000	Inparanoid score	I1133
OMA	1	1.010	-	-		QHG63482
OrthoDB	1	1.010	-	-		D118111at33208
OrthoFinder	1	1.000	-	-		FOG0003346
OrthoInspector	1	1.000	-	-		oto40545
orthoMCL	1	0.900	-	-		OOG6_103367
Panther	1	1.100	-	-	LDO	PTHR12670
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4679
SonicParanoid	1	1.000	-	-		X3230
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.900