DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDase and LOC100494440

DIOPT Version :9

Sequence 1:	NP_001263109.1	Gene:	CDase / 43618	FlyBaseID:	FBgn0039774	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_031762500.1	Gene:	LOC100494440 / 100494440	-ID:	-	Length:	761	Species:	Xenopus tropicalis

Alignment Length:	688	Identity:	297/688 - (43%)
Similarity:	406/688 - (59%)	Gaps:	41/688 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YKVGVGRADITGPPVEINFMGYANIKQVGRGIHTRVFARAFVV-EDEKGNRVAFVSADAGMMGYG 88
            |::||||.|.||...|:..||||...|:..|:|.|.::|||:: |.:...||.:||.:.|||...
Frog    89 YRIGVGRTDCTGLLAEVPLMGYAKSDQIASGLHLRQYSRAFIIAEPDDSKRVVYVSTNIGMMSQR 153

  Fly    89 LKREVIKRLQARYGNIYHNDNVAISGTHTHGAPGGFLMHLLYDISILGF-VPQTFEVMAQGLYLC 152
            ::.||::.|:..|||:|..|||.:|.::||..|.|:..:..:.::..|| .||| .|:..|:...
Frog   154 VRLEVMEELKVNYGNLYREDNVILSASNTHSGPAGYFQYNTFVLASQGFNRPQT-NVIVSGIVKS 217

  Fly   153 IKRATDNLVDGRILLSKTTVLNVNINRSPSSYLRNPAEERAQYEHDTDKTLTQLRFVDLENNLLG 217
            |:||..|:..|:|.::|.||.|..|||||||||.||..||.:|..:|||.:..|:.||:.:..:|
Frog   218 IERAHQNMKRGKIFMNKGTVENSQINRSPSSYLLNPESERIRYSSNTDKDMVILKMVDMNDQDMG 282

  Fly   218 AFNWYAVHATSMNNTNRLVTSDNVGYAALLLEKEYNPNKMPGKGKFVGAFCSSNLGDVSPNIMGP 282
            ..:|:|||..||.|.|:|::|||:|||:.|.|:|.|...:||.|.||.||..|||||||||.|||
Frog   283 MISWFAVHGVSMGNANKLISSDNLGYASYLFEQEKNNRSLPGTGSFVAAFSPSNLGDVSPNTMGP 347

  Fly   283 KCSISGNECDLLTSRCPTGEG-DCFASGPGKDMFESTQILGQRLADAALGLLNEQSQESTAREVT 346
            .|..:...||..||.||.|.. .|.|.||||||||||:|:|:|:...|..|....|     ||:.
Frog   348 HCVNANETCDNPTSTCPAGGSVACVALGPGKDMFESTKIIGERIFLKAKELYGNAS-----RELD 407

  Fly   347 GDVRFIHQFVDMPNYNGSTYNPLSRKVDKIRGCQPAMGYSFAAGTTDGPGAFSFEQGTTTDNPMW 411
            ..|.|.||:|||.|.....     .:...::.|:||:|||||||||||.|:.:|.|||...:..|
Frog   408 KKVNFAHQWVDMSNVTVKL-----NETHSVKTCKPALGYSFAAGTTDGAGSINFTQGTLEGDLYW 467

  Fly   412 NFVRD-FIAAPTQEDIKCHEPKPILLATGRATFPYEWQPKIVSDQLLKIGDVIIAAVPCEFTTMA 475
            |.:|| ::.||::|..:||.|||||:.||:...|..|.||||..|:..||.:.:.|:|.||||||
Frog   468 NAIRDLYLGAPSKETQECHHPKPILINTGQMDKPIPWHPKIVDIQMFTIGSIALLALPGEFTTMA 532

  Fly   476 GRRLRNQIRAAASAVGGIDTEVIIAGLTNIYTSYTVTPEEYQAQRYEAASTIFGPHTHSIYMDVF 540
            ||||:.:::......|.::|:|:::||.|:||.|..|.||||||||||||||:||||.|.|:.:|
Frog   533 GRRLQEEVKKILDPSGTLNTDVVLSGLCNVYTHYITTYEEYQAQRYEAASTIYGPHTLSAYLQLF 597

  Fly   541 ERLTKAMMRNET--VDAGPSPPYMNDVML--SLNTGVLFDGHPINTDFGYVKSQPNKEYGINETV 601
            ..|.||::.|.|  :..||.||.:|:.:|  || ..|..|..|.|.|||.|.......|...:.|
Frog   598 NGLAKAIVENTTDELPKGPRPPLINESLLPNSL-PPVPPDSTPANKDFGDVLKDVYPRYRRGDIV 661

  Fly   602 KVTYISGNPRN--NLFTEKTYFTIERKINEDRWKVAYTDASWETKMVWHR--TNTILGFSEMDIY 662
            ..|:::.|||:  |..:|.:|..: ||.|..  .:.|.||||||:..||:  .|.    |.....
Frog   662 SCTFVAANPRSGVNRMSESSYVYV-RKHNSR--VMLYNDASWETRYYWHKGPGNQ----SNATAE 719

  Fly   663 WDISPQTLPGEYRIRHSGEYK----------YILGGKY 690
            |.|.....||.|.|...|.|:          ||.|..:
Frog   720 WHIPLSAEPGLYYIEVCGYYQPRSSFPVPQVYIGGSSF 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDase	NP_001263109.1	PTZ00487	24..701	CDD:240437	297/688 (43%)
		Ceramidase_alk	25..538	CDD:282576	241/516 (47%)
		Ceramidse_alk_C	540..701	CDD:293653	56/169 (33%)
LOC100494440	XP_031762500.1	Ceramidase_alk	89..595	CDD:398420	241/516 (47%)
LOC100494440	XP_031762500.1	Ceramidse_alk_C	597..760	CDD:407221	56/169 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H10310
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118111at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010