Protein Alignment CDase and asah2

DIOPT Version :10

• Sequence 1: NP_651797.1
• Gene: CDase / 43618
• FlyBaseID: FBgn0039774
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_001123830.1
• Gene: asah2 / 100170585
• XenbaseID: XB-GENE-1003068
• Length: 763
• Species: Xenopus tropicalis
• Alignment Length: 691
• Identity: 299/691 - (43%)
• Similarity: 417/691 - (60%)
• Gaps: 33/691 - (4%)

  Fly    27 VGVGRADITGPPVEINFMGYANIKQVGRGIHTRVFARAFVV-EDEKGNRVAFVSADAGMMGYGLK 90
            :||||||.||...::..||||:..|:..|||||.::|||:: |.:...|:.:||||.||:...::
 Frog    87 IGVGRADCTGLLADVPLMGYASSDQLAGGIHTRQYSRAFIIAEPDNSKRLVYVSADIGMVSQRVR 151

  Fly    91 REVIKRLQARYGNIYHNDNVAISGTHTHGAPGGFLMHLLYDISILGFVPQTFEVMAQGLYLCIKR 155
            .||:::|:|:|||:|..:||.:||||||..|.|:..:..:.::..||:....:.:..|:...|.:
 Frog   152 LEVMEKLKAKYGNLYRQENVILSGTHTHSGPAGYFQYTTFMLTGKGFIRPATDAIVNGIVKSIDQ 216

  Fly   156 ATDNLVDGRILLSKTTVLNVNINRSPSSYLRNPAEERAQYEHDTDKTLTQLRFVDLENNLLGAFN 220
            |..|:..|||.|:|.||.|..:||||||||:||..||.:|..:|||.:..|:.||:.|..:|..:
 Frog   217 AHQNMKRGRIFLNKGTVENSQLNRSPSSYLQNPESERLRYPSNTDKDMVVLKMVDMHNQDMGIIS 281

  Fly   221 WYAVHATSMNNTNRLVTSDNVGYAALLLEKEYNPNKMPGKGKFVGAFCSSNLGDVSPNIMGPKCS 285
            |:||||.||.|.|.|::|||:|||:.|.|:|.|...:||:|.||.||.:||.||||||..||.|.
 Frog   282 WFAVHAVSMPNINHLISSDNLGYASYLFEQEKNSGYLPGEGPFVAAFTTSNHGDVSPNTKGPWCV 346

  Fly   286 ISGNECDLLTSRCPT-GEGDCFASGPGKDMFESTQILGQRLADAALGLLNEQSQESTAREVTGDV 349
            .:|:.||...|.||. |...|.|.|||.||||:|:|:|:.:...|..|.:..|     ||:...|
 Frog   347 NTGDSCDNPGSSCPIGGVSTCVALGPGNDMFENTKIIGEHIFQKAKELFSNSS-----RELEKKV 406

  Fly   350 RFIHQFVDMPN----YNGSTYNPLSRKVDKIRGCQPAMGYSFAAGTTDGPGAFSFEQGTTTDNPM 410
            .|.||:|||.|    .|| |::..:        |:||:||||||||.||||..:|.||....:|.
 Frog   407 DFAHQWVDMSNVTVQLNG-THSATT--------CKPALGYSFAAGTIDGPGLINFTQGAVEGDPF 462

  Fly   411 WNFVRD-FIAAPTQEDIKCHEPKPILLATGRATFPYEWQPKIVSDQLLKIGDVIIAAVPCEFTTM 474
            |:.:|| .:..|:.|..:||.|||||:.||..:.|..|.|.||..|:..||.:.:.|||.|||||
 Frog   463 WDGIRDAILGVPSNETQECHSPKPILINTGEMSQPLPWHPTIVDVQMFTIGSLAMLAVPGEFTTM 527

  Fly   475 AGRRLRNQIRAAASAVGGIDTEVIIAGLTNIYTSYTVTPEEYQAQRYEAASTIFGPHTHSIYMDV 539
            :|||||..::......|..|.:|:::||.|:||.|..|.||||||||||||||:||||.:.|..:
 Frog   528 SGRRLREDVQKVLDPAGTQDVQVVLSGLCNVYTHYITTFEEYQAQRYEAASTIYGPHTLAAYQQL 592

  Fly   540 FERLTKAMMRNETVD--AGPSPPYMNDVML-SLNTGVLFDGHPINTDFGYVKSQPNKEYGINETV 601
            |..|.:|::.|:..:  .||.||:.|:..| |....|..|..|.||.||.|..:...:|.:.|..
 Frog   593 FRGLARAIVENKVAELPKGPQPPFFNESQLFSFLLPVPVDKAPGNTTFGDVLEEVKPQYTVGEVA 657

  Fly   602 KVTYISGNPRNNL--FTEKTYFTIERKINED--RWKVAYTDASWETKMVWHRTNTILGFSEMDIY 662
            .||:::||||:::  ...|||..:| |.|:|  .|...:.||||||:..|::.:.......|:
 Frog   658 SVTFVTGNPRSSVEHLAGKTYLAVE-KYNKDTGEWHTVHNDASWETRYYWNKVSRDQSNGTME-- 719

  Fly   663 WDISPQTLPGEYRIRHSGEYK--YILGGKYPYEGLTHSFTV 701
            |.|.|...||.|||.|.|.||  .:.....||||::..|.|
 Frog   720 WHIPPSAQPGIYRIHHFGHYKERNLPVTIKPYEGISSEFEV 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDase	NP_651797.1	Ceramidase_alk	25..538	CDD:461415	238/517 (46%)
		Ceramidse_alk_C	540..701	CDD:465340	60/169 (36%)
asah2	NP_001123830.1	Ceramidase_alk	86..591	CDD:461415	238/517 (46%)
		Ceramidse_alk_C	593..760	CDD:465340	60/169 (36%)