DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2224 and Stambpl1

DIOPT Version :9

Sequence 1:	NP_001263108.1	Gene:	CG2224 / 43617	FlyBaseID:	FBgn0039773	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_001347645.1	Gene:	Stambpl1 / 76630	MGIID:	1923880	Length:	436	Species:	Mus musculus

Alignment Length:	431	Identity:	178/431 - (41%)
Similarity:	252/431 - (58%)	Gaps:	42/431 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VEPQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTLFIEK 77
            :.|:||::.||..|..|.:::::...||:|||.||.|||:|||.|||.||||:||.:::|||:||
Mouse    24 LSPEERVRALSKLGCNISINEDITPRRYFRSGVEMERMASVYLEEGNLENAFVLYNKFITLFVEK 88

  Fly    78 IRQHPDYGSVKA-EVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQFLASK---EAERVKELER 138
            :..|.||..... |.:||.:|:|:...|.|::|:..||..|..||:::|.||   :||.:|:||.
Mouse    89 LPSHRDYQQCAVPEKQDIMKKLKEIAFPRTDELKTDLLRKYNIEYQEYLQSKNKYKAEILKKLEH 153

  Fly   139 ERERERERQR-------QKERE---------KAGSSAIPSLIPANLHVLID--EGNQPSAPDLGL 185
            :|..|.||||       |.|.|         |....|...:...:..||.:  :|:..|.
Mouse   154 QRLIEAERQRIAQMRQQQLESEQFLFFEDQLKKQELARGQIRGQDSPVLSEQTDGSALSC----- 213

  Fly   186 LDQVVYPNDFPTGANRSLPGSGLLLPAASEAAADKTTNSKPSFDRNQKP--SYNRTDSLLAGSLR 248
                     |.|..:.||..:....|..|:.:  ...|..|..:|..||  :.:...:|:...||
Mouse   214 ---------FSTHQSNSLRNAFADHPHKSDGS--NFANYSPPVNRALKPAATLSAVQNLVVEGLR 267

  Fly   249 LVYVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTPDSCNTMHEEQIF 313
            .|.:..|....||.||.:||.:.|||||:|.|.|:.|:..|||::.|:|...||.|:..:.|::|
Mouse   268 CVVLSRDLCHKFLLLADSNTVRGIETCGILCGKLTHNEFTITHVVVPKQSAGPDYCDVENVEELF 332

  Fly   314 DVQDQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNTTGFFILTPHYGL 378
            :||||..|:|||||||||||||||||||||||||||:|:|||:||||:||:..||.|.|| :.|:
Mouse   333 NVQDQHGLLTLGWIHTHPTQTAFLSSVDLHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLT-NAGM 396

  Fly   379 DYIAQCRQSGFHPHPNDPPLFMEAQHIRMDNQAKIKVIDLR 419
            ..::.|::.|||||..||.||....|: :....|..|:|||
Mouse   397 LEVSTCKKKGFHPHTKDPKLFSICSHV-LVKDIKTTVLDLR 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_001263108.1	USP8_dimer	16..119	CDD:286108	47/103 (46%)
CG2224	NP_001263108.1	MPN_AMSH_like	247..419	CDD:163697	91/171 (53%)
Stambpl1	NP_001347645.1	USP8_dimer	28..129	CDD:370218	46/100 (46%)
		Tig	<119..>195	CDD:223618	25/75 (33%)
		MPN_AMSH_like	266..436	CDD:163697	91/171 (53%)
		JAMM motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01182	347..360		12/12 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836834
Domainoid	1	1.000	147	1.000	Domainoid score	I4492
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2459
Isobase	1	0.950	-	0	Normalized mean entropy	S4988
OMA	1	1.010	-	-		QHG49824
OrthoDB	1	1.010	-	-		D411229at2759
OrthoFinder	1	1.000	-	-		FOG0002716
OrthoInspector	1	1.000	-	-		otm43492
orthoMCL	1	0.900	-	-		OOG6_103166
Panther	1	1.100	-	-	O	PTHR12947
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1584
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.720